Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs

Objectives: Oxygen desaturation during tracheal intubation is known to be associated with adverse ICU outcomes in critically ill children. We aimed to determine the occurrence and severity of desaturation during tracheal intubations and the association with adverse hemodynamic tracheal intubation–associated events. Design: Retrospective cohort study as a part of the National Emergency Airway Registry for Children Network’s quality improvement project from January 2012 to December 2014. Setting: International PICUs. Patients: Critically ill children younger than 18 years undergoing primary tracheal intubations in the ICUs. Interventions: tracheal intubation processes of care and outcomes were prospectively collected using standardized operational definitions. We defined moderate desaturation as oxygen saturation less than 80% and severe desaturation as oxygen saturation less than 70% during tracheal intubation procedures in children with initial oxygen saturation greater than 90% after preoxygenation. Adverse hemodynamic tracheal intubation–associated event was defined as cardiac arrests, hypo or hypertension requiring intervention, and dysrhythmia. Measurements and Main Results: A total of 5,498 primary tracheal intubations from 31 ICUs were reported. Moderate desaturation was observed in 19.3% associated with adverse hemodynamic tracheal intubation–associated events (9.8% among children with moderate desaturation vs 4.4% without desat...
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Related Links:

HIGH blood pressure symptoms don ’t always appear, meaning many people don’t get diagnosed until they go for a check-up with their GP. Treatment for the condition involves losing weight and a change in diet to lower blood pressure. You can eat this vegetable to help reduce your blood pressure.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Wolf J, Narkiewicz K Abstract INTRODUCTION: Highly prevalent sleep disordered breathing (SDB) has been recognized as an independent cardiovascular disease (CVD) risk factor. Although these two entities often coexist, there is a shortage of sufficiently-powered studies testing the interplay between the course of sleep apnea and CVD pharmacotherapy. The mutual relationship between treated/untreated obstructive sleep apnea (OSA) with ongoing cardiovascular pharmacotherapies is an evident gap in clinical expertise. Areas covered: In this article, the authors review the available evidence and outline future res...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
HIGH blood pressure symptoms include headaches, chest pain and difficult breathing. Making this takeaway diet swap could make your Indian or Chinese meal more healthy, and lower your risk of hypertension.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 25 May 2018 Source:Pharmacology & Therapeutics Author(s): Amreen Mughal, Stephen T. O'Rourke Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain. A growing body of evidence now demonstrates a regulatory role for the apelin/APJ receptor system in cardiovascular physiology and pathophysiology, thus making it a potential target for cardiovascular drug discovery and development. Indeed, ongoing studies are investigating the potential benefits of apelin and apel...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe findings of this pilot study suggest that increased lipid peroxidation is associated with insulin resistance and hypertension in obese children and adolescents, while OSA has most likely minor influence.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Conclusion: Our study demonstrated that betaine attenuated PAH through its anti-inflammatory effects. Hence, the present data may offer novel targets and promising pharmacological perspectives for treating monocrotaline-induced PAH.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
FRIDAY, May 25, 2018 -- The 2017 American College of Cardiology/American Heart Association hypertension guideline is associated with an increase in the proportion of adults recommended for antihypertensive treatment compared with the 2014 guideline,...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Abstract Treatments for metabolic diseases, such as diet and therapeutics, often provide short-term therapy for metabolic stressors, but relapse is common. Repeated bouts of exposure to, and relief from, metabolic stimuli results in a phenomenon we call "metabolic cycling." Recent human and rodent data suggest metabolic cycling promotes an exaggerated response and ultimately worsened metabolic health. This is particularly evident with cycling of body weight and hypertension. The innate and adaptive immune systems have a profound impact on development of metabolic disease, and current data suggest that im...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
FRIDAY, May 25, 2018 (American Heart Association) -- A daily dose of aspirin could help pregnant women in the first stage of high blood pressure avoid a condition that puts both mother and baby in danger, according to a new study. New guidelines...
Source: - Daily MedNews - Category: General Medicine Source Type: news
HIGH blood pressure symptoms include headaches, chest pain and difficulty breathing. You can compare your hypertension risk with a normal blood pressure for your age. Are you at risk of the deadly condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: Children | Emergency Medicine | Hypertension | Pediatrics | Study