Vascular Access in Critically Ill Pediatric Patients With Obesity*

Conclusions: Severe obesity is associated with decreased overall likelihood of placement of a vascular access device but increased likelihood of peripherally inserted central catheter placement and of device-related complications.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Articles Source Type: research

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(Reuters Health) - Young and middle-aged women who are overweight or obese may be more likely to develop a leaky bladder, researchers say.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Kutlu O, Kaleli HN, Ozer E Abstract The proportion of obese or diabetic population has been anticipated to increase in the upcoming decades, which rises the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Recent evidence indicates that NASH is the main cause of chronic liver diseases and it is an important risk factor for development of hepatocellular carcinoma (HCC). Although the literature addressing NASH-HCC is growing rapidly, limited data is available about the etiology of NASH-related HCC. Experimental studies on the molecular mechani...
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
Publication date: Available online 20 September 2018Source: Science &SportsAuthor(s): A. Ardoin, B. CanotRésuméIntroductionDe nombreuses études prouvent l’intérêt de la pratique sportive dans la prise en charge curative des patients, comme dans la prévention, primaire, secondaire comme tertiaire, de nombreuses maladies chroniques. L’action « À Reims Sportez votre santé » a pour but de remettre dans une pratique sportive régulière des patients sédentarisés et présentant des pathologies chroniques. ...
Source: Science and Sports - Category: Sports Medicine Source Type: research
Clinicians should counsel women that maintaining a healthy weight may help prevent urinary incontinence now or later in life, the authors suggest.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Diabetes & Endocrinology News Source Type: news
Conclusionthere are neither certain data which evidence a correlation between obesity and GCT, nor data to support the hypothesis of a higher incidence of GCT after bariatric surgery. Based on our experience in obese patients the finding of GCT in the pre-operatory phase is not an absolute contraindication for bariatric surgery.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Authors: Sezik M, Gurpinar E, Zayim N Abstract The aim was to perform a document content analysis of the subject titles in the undergraduate obstetrics and gynaecology (OG) curricula in Turkish medical schools regarding the National Core Curriculum revised in 2014 (NCC-2014). Two mini-focus group discussions with four voluntary OG faculty members in each session and one of the authors as the moderator were employed within a 1-week time frame to identify the primary (n = 36) and secondary (n = 15) NCC-2014 OG titles that were then compared for the alignment with the curricula of the vario...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Publication date: Available online 19 September 2018Source: Trends in Endocrinology &MetabolismAuthor(s): Z. HochbergAn evolutionary approach to obesity involves a genomic/anthropological dimension. For 1.8 Myr the lifestyle of hunter-gatherers (HGs) comprised intense physical activity and a high-protein/low-carbohydrate diet. Genomes of HGs were adapted to low insulin sensitivity. When the agrarian epoch began a new ‘farmer diet’ high in carbohydrates (CHO) emerged. Owing to periodic famines, the genome may not have adapted; they preserved a HG genome. Ever since the industrial revolution our genome is ada...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
ConclusionSOur study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
In this study, miR-143a-3p was highly expressed in adipose tissues of obese mice, and was up-regulated at the middle and last stage of 3T3-L1 adipocyte differentiation. Using mouse 3T3-L1 cells line, which is an ideal model in vitro for the study of adipogenesis, we observed that overexpression of miR-143a-3p inhibited the preadipocyte proliferation, and enhanced the preadipocyte differentiation. In contrast, the inhibition of miR-143a-3p expression promoted the preadipocyte proliferation, and inhibited the preadipocyte differentiation. Further analysis suggested that miR-143a-3p mediating preadipocyte differentiation migh...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential therapeutic agents. Several factors can influence wound healing. These include aging, infection, medications, nutrition, obesity, diabetes, venous insufficiency, and peripheral arterial disease. Lack of optimal preclinical models that are capable of properly recapitulating human wounds remains a significant translational challenge. Animal models should strive for reproducibility, quantitative interpretation, clinical relevance, and successful translation into clinical use.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Research Techniques Made Simple Source Type: research
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