3D printing and cryogenics could create new potential for artificial organs
[Image from Imperial College London]Researchers at Imperial College London have developed a technique to replicate biological structures using cryogenics and 3D printing. The research is a first from the university to create structures that are soft enough to replicate the mechanical properties of organs like the brain and lungs. The 3D printing technique could create replica organs and assist with tissue regeneration. Structure and softness of body tissues can be difficult to match, but when they are matched, the structures could be used in medical procedures to form scaffolds that can be a template for tissue regeneration. Damaged tissues would be bolstered to regrow, allowing the body to heal without issues like rejection from the body. Get the full story on our sister site, Medical Design &Outsourcing. The post 3D printing and cryogenics could create new potential for artificial organs appeared first on MassDevice.
Conclusions: QCT metrics demonstrate stronger correlations with FEV1 and are better predictors of pulmonary function than SQS. SQS performs moderately well in bilateral LTx, but poorly on unilateral LTx. In unilateral LTx, QCT metrics from the transplanted lung are better predictors of FEV1 than QCT metrics from the nontransplanted lung.
We report that microhemorrhage-related iron content may be a major determinant of A. fumigatus invasion and, consequently, its virulence. Invasive growth was increased during progressive alloimmune-mediated graft rejection associated with high concentrations of ferric iron in the graft. The role of iron in A. fumigatus invasive growth was further confirmed by showing that this invasive phenotype was increased in tracheal transplants from donor mice lacking the hemochromatosis gene (Hfe–/–). The invasive phenotype was also increased in mouse syngrafts treated with topical iron solution and in allograft recipient...
We report in detail two cases of fulminant idiopathic acute lung injury requiring extracorporeal membrane oxygenation in previously healthy young adults with acute respiratory distress syndrome, one of whom required lung transplantation. Biopsies showed diffuse alveolar injury with a striking paucity of alveolar epithelial regeneration, rare hyaline membranes, and diffuse contiguous airspace lining by macrophages.
Authors: Huang S, Tang Y, Zhu Z, Yang J, Zhang Z, Wang L, Sun C, Zhang Y, Zhao Q, Chen M, Wu L, Wang D, Ju W, Guo Z, He X Abstract BACKGROUND The inherent challenges of selecting an acceptable donor for the increasing number and acuity of recipients has forced programs to take increased risks, including accepting donors with a cancer history (DWCH). Outcomes of organ transplantation using organs from DWCH must be clarified. We assessed transplant outcomes of recipients of organs from DWCH. MATERIAL AND METHODS Retrospective analysis of the Scientific Registry of Transplant Recipients data from January 1, 2000 to De...
PMID: 29455798 [PubMed - in process]
Conclusions ML utilizing qCT could discern distinct mechanisms driving FEV1 decline in BOS and non-BOS LTx patients and predict eventual onset of BOS. This approach may become useful to optimize management of LTx patients.
Renal rejection clinically represents a major cause of graft dysfunction and sadly the loss of the renal transplant. This is despite the considerable progress in immunosuppressive therapy. It is strongly believed that the complex immunologic network underlying the response against major histocompatibility molecules (MHC) is responsible for rejection, an unresolved issue that is, in part, not inhibited by the current prophylactic and therapeutic strategies. Extracorporeal photopheresis (ECP) is an effective cell therapy approach that was successfully used in immunomodulating heart rejection, acute and chronic GvHD, lung rej...
We thank Dr. Bizouarn and colleagues for their interest in our publication1 and welcome their efforts in working towards meeting the public healthcare need for the treatment of advanced heart failure. The article Effects of pre-load variations on hemodynamic parameters with a pulsatile autoregulated artificial heart during the early post-operative period details the first clinical case using the Carmat Total Artificial Heart (C-TAH) with auto-mode functioning.2 Utilizing it in clinical practice was interesting, given that SynCardia Total Artificial Heart (TAH) also aims to operate under a similar mechanism with full eject parameters.
Ex vivo lung perfusion (EVLP) has become one of the most promising techniques for allowing assessment and potential reconditioning of donor lungs being offered for lung transplantation. This technique was pioneered by Stig Steen in Lund1 and brought into more widespread clinical use by Marcelo Cypel and Shaf Keshavjee in Toronto.2,3 EVLP has the potential to revolutionize accessibility of lung transplantation, in a large part due to its ability to expand the pool of available donor lungs by at least 20%.