Oldie but Goodie Pediatric Clinical Concepts

​A number of older clinical concepts may be unfamiliar to younger clinicians, but these clinical concepts are useful in pediatric medicine. Some of these concepts showed up in the medical literature for the first time nearly a century ago. Physicians should feel free to question the potential value and validity of older clinical concepts that aren't at the forefront of medical education, but my experience of more than 30 years practicing pediatrics and emergency medicine has repeatedly affirmed to me that these are valuable in emergency medicine.​Parenteral DiarrheaThe concept of parenteral diarrhea has been around for at least a century. (Can Med Assoc J 1922;12[8]:554; Proc R Soc Med 1944;37[9]:479; Pediatrics 1948;2[5]:525.) It is often not recognized, acknowledged, or discussed as an important clinical entity, however. This type of diarrhea is caused by infections outside the gastrointestinal tract. The pathophysiology is unclear, but infections elsewhere in the body such as otitis media or (more frequently) urinary tract infections are often associated with diarrhea.The diarrhea, however, can be characterized as different from the diarrhea patterns commonly seen with gastrointestinal diseases. Parenteral diarrhea is typically only two or three loose stools a day rather than the five to 10 watery stools seen with most cases of acute gastroenteritis. Parenteral diarrhea can also occur in concordance with occasional vomiting and fever. I have seen this pattern so many t...
Source: M2E Too! Mellick's Multimedia EduBlog - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

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Publication date: Available online 23 August 2019Source: Journal of Hospital InfectionAuthor(s): Oyebola Fasugba, Brett G. Mitchell, Elizabeth McInnes, Jane Koerner, Allen C. Cheng, Heilok Cheng, Sandy MiddletonSummaryBackgroundNon-antibiotic interventions for urinary tract infection (UTI) prevention have been investigated as a strategy to reduce antibiotic prescribing for UTI and subsequent antibiotic resistance. Increased hydration is widely advocated for preventing UTI; however, evidence for its effectiveness is unknown.AimTo systematically review the published literature on the effectiveness of increased fluid intake a...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionsThe purpose of this case series is to highlight the highly drug resistant profile of this organism and the fulminant infection it can cause, which if spreads in our hospitals due to breaches in infection control practices, can pose risk as a deadly and untreatable nosocomial infection.
Source: IDCases - Category: Infectious Diseases Source Type: research
Conclusion: The perception of health risk of contracting influenza and a primary healthcare physicians' recommendation played an important role in shaping participants' decisions towards vaccination. Primary healthcare physicians are invited to assess and if necessary adjust inappropriate prevention behaviour through their everyday patient consultations as well as add to the knowledge about influenza severity and influenza vaccination benefits to their patients. PMID: 31431093 [PubMed - as supplied by publisher]
Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
ConclusionsLPS reduced cell proliferation and VEGF secretion of PDLSCs, suggesting that periodontal pathogens might reduce the capability of PDLSCs in periodontal regeneration. Yet, LPS treated PDLSCs remained viable and VEGF secretion increased significantly over time. Further research is needed to study the potential use of PDLSCs in periodontal regeneration and the relationship of biofilm LPS accumulations.
Source: The Saudi Dental Journal - Category: Dentistry Source Type: research
Publication date: December 2019Source: Food Packaging and Shelf Life, Volume 22Author(s): Samira Dehghani, Seyed Hadi Peighambardoust, Seyed Jamaleddin Peighambardoust, Seyed Vali Hosseini, Joe M. RegensteinAbstractThis work dealt with antibacterial nanoparticles of silver (Ag), copper oxide (CuO), and zinc oxide (ZnO) and incorporated their combination at a reduced concentration to low-density polyethylene (LDPE) to prepare active packaging films. SEM (scanning electron microscopy) and SEM-energy dispersive X-ray (EDAX) observations showed a relatively homogenous distribution of nanoparticles on the fracture surfaces of t...
Source: Food Packaging and Shelf Life - Category: Food Science Source Type: research
Authors: Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S Abstract OBJECTIVE: Gut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. BACKGROUND: AD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, whereas the microbiota in MCI before the onset of dementia has not been discovered and characterized in hum...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 22 August 2019Source: Microbial PathogenesisAuthor(s): Waad D. Alrohily, Mahmoud E. Habib, Shahenda M. El-Messery, Abdulmalik Alqurshi, Hussein El-Sabagh, El-Sayed E. HabibAbstractSome synthesized antitumor derivatives of thiazole based chalcones including thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues were subjected to be tested against standard microbial strains. Compound 18 showed higher activity against both Gram-positive and Gram-negative bacteria with MIC of 1.0, 1.0, 2.0, 2.0 and 4.0 μg/ml against S. aureus, B. subtilis, M. luteus, E. coli and ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Abstract Halophilic proteins have greater abundance of acidic over basic residues in sequence. In structure, the surface is decorated by negative charges, with lower content of Lysine. Using sequence BLOCKs and 3D model of malate dehydrogenase from halophilic archaea (Halobacterium salinarum; hsMDH) and X-ray structure from mesophilic bacteria (E. coli; ecMDH), we show that not only acidic and basic residues have higher mean relative abundance (MRA) and thus, impart higher polarity to the sequences, but also show their presence in the surface of the structure of hsMDH relative to its mesophilic counterpart. These ...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Authors: Wu KK, Borba AJ, Deng PH, Armstrong AW Abstract The association between atopic dermatitis (AD) and conjunctivitis in adults has not been well established. We conducted a cross-sectional study of the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) from 2002-2015 in order to evaluate the association between AD and conjunctivitis in U.S. adults. We performed multivariable logistic regression analyses adjusting for sociodemographic factors. An estimated total [95% CI] of 8,581,098 [7,592,037-9,570,160] weighted AD visits and 12,853,199,920 [12.808,2...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
In this study, biogenic lanthanum (La) nanoparticles were synthesized through ecofriendly green chemistry methodology. Mutingia calabura leaf extract was used for the synthesis of La nanoparticles. The synthesized La nanoparticles were characterized using FTIR, SEM and EDAX. Further, the nanoparticles were analysed for antibacterial activity, bacterial toxicity, antioxidant activity, blood compatibility and dye degradation efficiency. Well diffusion technique was used to study the antibacterial activity and antioxidant activity was evaluated using DPPH assay. Photocatalytic dye degradation study was carried out with Coomas...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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