Human and Autologous Adipose-derived Stromal Cells Increase Flap Survival in Rats Independently of Host Immune Response
Conclusions Flap survival increased with SVF treatment regardless of human or autologous origin, suggesting that increased flap survival is independent of the host immune response. All cell injections lead to increased vessel density, but it did not necessarily lead to increased flap survival. Further research should elaborate which molecular events make SVF treatment more efficacious than ASC.
Condition: Gastrointestinal System Cancer Intervention: Biological: FMT capsule Sponsor: Peking University Not yet recruiting
Conditions: Pancreas Transplant Rejection; Kidney Transplant Rejection Intervention: Diagnostic Test: Allosure Test Sponsors: Rush University Medical Center; CareDx Not yet recruiting
This article aims to review the results of the studies on microbiota in animal models and children and discuss the emerging clinical relationship of ASD and gut microbiota. PMID: 31613980 [PubMed - in process]
Conclusions: Recipients of experimental HCV D+/R- transplants generally seemed to recognize the risks and benefits of these novel transplants and did not regret participating. Such salutary reported experiences are important in assessing the appropriateness of further research into the feasibility of HCV D+/R- transplants. PMID: 31618112 [PubMed - as supplied by publisher]
ConclusionThis study reiterates the importance of individual profiling of gut microbiota in HSCT patients.
Conclusion: In this sophisticated experimental model of OLT, RIC-induced hepatoprotective effects were associated with a downregulation of MIF at mRNA and protein levels, suggesting the role of MIF as a mediator in RIC-induced protection following OLT.
Abstract Organisms can change their environment and in doing so change the selection they experience and how they evolve. Population density is one potential mediator of such interactions because high population densities can impact the ecosystem and reduce resource availability. At present, such interactions are best known from theory and laboratory experiments. Here we quantify the importance of such interactions in nature by transplanting guppies from a stream where they co-occur with predators into tributaries that previously lacked both guppies and predators. If guppies evolve solely because of the immediate ...
ConclusionsIn conclusion, PLDRH is a feasible and safe procedure with a learning curve of 65 –70 cases.
Increased tuberculosis (TB) disease risk has consistently been observed among solid organ transplant recipients [1, 2]. This may result from post-transplant immunosuppressive therapy, although underlying disease processes leading to transplant (including chronic kidney disease) are also associated with increased risk . TB among transplant recipients is associated with increased risk of drug toxicity, drug–drug interactions, graft failure and mortality , and can lead to transmission to other vulnerable hospitalised patients. Consequently, global guidelines recommend systematic screening of patients undergoing so...
We present the reader with a brief review on the AHCT procedure, its immunomodulatory mechanism of action in MS, the most recent evidence in support of its use in patients with relapsing-remitting multiple sclerosis (RRMS), as well as its cost considerations.Recent findingsThe first meta-analysis of clinical trials of AHCT for patients with MS demonstrated durable 5-year progression-free survival rates and low treatment-related mortality. Recently, the first randomized controlled phase III clinical trial demonstrated AHCT to be superior to best available therapy for a subset of patients with RRMS. This led to the American ...