Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis

Conclusions Our study revealed that AMF enhances biomechanical strength, regeneration, and bony union after radiation in a murine model of DO. The use of prophylactic AMF in combination with DO offers the promise of an alternative reconstructive option for patients afflicted with head and neck cancer.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Research Source Type: research

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Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: The studies have shown hearing loss in higher frequencies, but in our study, we have observed hearing loss at speech frequency in 22.2% of patients receiving cisplatin, who also had low serum albumin levels. Periodic audiometric monitoring and serum albumin level may be helpful to provide timely intervention to prevent further hearing loss and deterioration in the quality of life.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Intensity-modulated radiation therapy (IMRT) leads to increased reduction in late toxicities compared to 3-dimensional conformal radiation therapy (3D-CRT) techniques [1]. In IMRT, dose distributions conform to tumor topography while simultaneously limiting the normal tissue volume exposed to relatively high radiation doses. Therefore, IMRT has become the recommended treatment strategy for many cases of locally advanced head and neck cancer (HNC). However, IMRT treatment plans for HNC typically use a high number of radiation fields and may be associated with new beam-path non-target tissue toxicities such as anterior oral ...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original article Source Type: research
Docetaxel is an antimicrotubules cytotoxic agent prescribed widely by medical oncologists in multiple tumor types (breast, lung, prostate, stomach, head, and neck). However, the side effects of docetaxel are numerous (cytopenia, peripheral edema, myalgia, arthralgia, alopecia, and sensitive neuropathy) and recent concerns have been raised about neutropenic enterocolitis in France. Here, we report the case of a 57-year-old patient with metastatic prostatic cancer, who developed a severe myositis and fasciitis grade IV 1 week after his second docetaxel infusion. We reviewed the five cases of docetaxel-related myositis descri...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Report Source Type: research
Authors: Owczarek W, Słowińska M, Lesiak A, Ciążyńska M, Maciąg A, Paluchowska E, Marek-Józefowicz L, Czajkowski R Abstract Overexpression of the epidermal growth factor receptor (EGFR) is found in many cancers, including those of the head and neck area, non-small-cell lung cancer, and colorectal, cervical, prostate, breast, ovary, stomach, and pancreatic cancer. The EGFR inhibitors are used at present in the treatment of such cancers. Skin lesions that develop during and after cancer treatment may be due to specific cytostatics, molecular-targeted drugs, radiation therapy, complementary therapy, or th...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Letter to Editor Source Type: research
es MD Abstract OBJECTIVE: To compare treatment outcome of patients with head and neck (HN) tumours treated with definitive Radiation Therapy (RT) that, mainly due to differences in the fractionation scheme used with simultaneous integrated boost techniques, resulted in a different biological dose. METHODS: 181 HN cancer patients, prescribed to about 70.2 Gy in the primary tumour, were included in this study. Population cohort was divided into Group
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
We examined the association between male‐pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals' Follow‐up Study. In 1992, participants reported their status of male‐pattern baldness at age 45 years by choosing from five crown‐view pictograms based on Norwood's classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed. We identified 327 melanoma cases, 1324 SCC cas...
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Body image (BI) is complex and multifaceted term. However, BI will be defined as one’s subjective perceptions, views and thoughts regarding their appearance. BI can be altered in many ways. For head and neck (HN) cancer patients, many physical and psychosocial changes may occur throughout treatment that may impact their BI. Physical changes may include skin reactions, mucositis, xerostomia, hair loss, dysphagia, feeding tubes or tracheostomy tubes. BI can impact quality of life (QOL), daily activities, self-esteem, self-confidence and cause depressive symptoms.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Source Type: research
Conclusion: We have established an animal model of radiation injury demonstrating physiological and histological changes corresponding to human radiation injuries, which can be used for future therapeutic evaluations.
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Source Type: research
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