Significance of Sarcopenia Evaluation in Acute Decompensated Heart Failure.

Significance of Sarcopenia Evaluation in Acute Decompensated Heart Failure. Int Heart J. 2018 Jan 15;: Authors: Tsuchida K, Fujihara Y, Hiroki J, Hakamata T, Sakai R, Nishida K, Sudo K, Tanaka K, Hosaka Y, Takahashi K, Oda H Abstract In patients with chronic heart failure (HF), the clinical importance of sarcopenia has been recognized in relation to disease severity, reduced exercise capacity, and adverse clinical outcome. Nevertheless, its impact on acute decompensated heart failure (ADHF) is still poorly understood. Dual-energy X-ray absorptiometry (DXA) is a technique for quantitatively analyzing muscle mass and the degree of sarcopenia. Fat-free mass index (FFMI) is a noninvasive and easily applicable marker of muscle mass.This was a prospective observational cohort study comprising 38 consecutive patients hospitalized for ADHF. Sarcopenia, derived from DXA, was defined as a skeletal muscle mass index (SMI) two standard deviations below the mean for healthy young subjects. FFMI (kg/m2) was calculated as 7.38 + 0.02908 × urinary creatinine (mg/day) divided by the square of height (m2).Sarcopenia was present in 52.6% of study patients. B-type natriuretic peptide (BNP) levels were significantly higher in ADHF patients with sarcopenia than in those without sarcopenia (1666 versus 429 pg/mL, P < 0.0001). Receiver operator curves were used to compare the predictive accuracy of SMI and FFMI for higher BNP levels. Areas under the cur...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research