Pharmacogenetic analysis of opioid dependence treatment dose and dropout rate.

CONCLUSIONS: This study suggests that functional polymorphisms related to synaptic dopamine or serotonin levels may predict dropout rates during methadone treatment. Patients with the S/S genotype at 5-HTTLPR in SLC6A4 or the Val/Val genotype at Val158Met in COMT may require additional treatment to improve their chances of completing addiction treatment. Replication in other methadone patient populations will be necessary to ensure the validity of these findings. PMID: 29333880 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29333880?dopt=Abstract

Source: The American Journal of Drug and Alcohol Abuse - January 15, 2018 Category: Addiction Authors: Crist RC, Li J, Doyle GA, Gilbert A, Dechairo BM, Berrettini WH Tags: Am J Drug Alcohol Abuse Source Type: research