The Biomarker Disruptor

Would you rather get a biopsy or a blood test to check for prostate cancer? Quanterix chairman/CEO Kevin Hrusovsky said with the help of his company's latest product, the SR-X Ultra-Sensitive Biomarker Detection System, a simple blood test could replace, or complement, invasive diagnostic procedures. Using digital technology, the SR-X can detect cancer, neurological disorders, inflammatory and infectious diseases, and heart events months or even years earlier, and less invasively, than existing technology.   Using Quanterix's single molecule array (Simoa) science, which is similar to a digital enzyme-linked immunosorbent assay (ELISA), the SR-X measures six biomarkers simultaneously with a roughly 1,000-fold improvement in sensitivity. This precision allows researchers to see proteins at a level not seen before; thus, detecting diseases when they're more easily treatable. As it builds its diagnostics division, Quanterix—which closed its IPO in December 2017—is putting its attention on two lower-risk areas: research, to discover and validate new biomarkers; and pharmaceuticals, where the company already has a strong foothold. During the 2018 JP Morgan Healthcare Conference in San Francisco, Hrusovsky said 23 of the top 25 pharmaceutical companies use Quanterix's technology. "There are ways to use biomarkers to make drugs less toxic and more effective by lowering the dose and making them more personalized," he explained in an interview. It's a worthwh...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news

Related Links:

ConclusionThe PET-only quantification method, CapAIBL, can produce reliable centiloid values. The bias observed in the AIBL dataset for 18F-NAV4694 and 18F-Florbetaben may indicate that using different scanners or reconstruction methods might require scanner-specific adjustments.
Source: NeuroImage - Category: Neuroscience Source Type: research
DiscussionWe applied a high-dimensional machine learning approach to estimate a novel AD risk factor for WHIMS-MRI study participants using ADNI data. The GM AD-PS scores showed strong associations with incident cognitive impairment and cross-sectional and longitudinal associations with age, cognitive function, cognitive status and WM SVID volume lending support to the ongoing validation of the GM AD-PS score.
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 18 August 2018Source: NeuroImageAuthor(s): Thomas Alderson, Arun L.W. Bokde, J.A. Scott Kelso, Liam Maguire, Damien Coyle, Alzheimer's Disease Neuroimaging InitiativeAbstractCurrent theory suggests brain regions interact to reconcile the competing demands of integration and segregation by leveraging metastable dynamics. An emerging consensus recognises the importance of metastability in healthy neural dynamics where the transition between network states over time is dependent upon the structural connectivity between brain regions. In Alzheimer's disease (AD) – the most common form o...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 18 August 2018Source: Clinica Chimica ActaAuthor(s): Huijun Chen, Xiaoqian Luan, Kai Zhao, Huihua Qiu, Yuntao Liu, Xinjie Tu, Wenjie Tang, Jincai HeAbstractsBackgroundPost-stroke depression (PSD) is the most common complication occurring among stroke survivors. It has been shown that increased neutrophil-to-lymphocyte ratio (NLR) is associated with depression. We explored the relationship between NLR and PSD.MethodsIn total, 299 ischemic stroke patients were consecutively enrolled in the study and received 1 month follow-up. The 17-Hamilton Rating Scale was used to measure depressive sy...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Authors: Kholodenko IV, Kalinovsky DV, Doronin II, Deyev SM, Kholodenko RV Abstract Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique features of this type of cancer frequently hamper the process of determining clinical presentation and predicting therapy effectiveness. The tumor can spontaneously regress without treatment or actively develop and give rise to metastases despite aggressive multimodal therapy. In recent years, immunotherapy has become one of the most promising approaches to the treatment of neuroblastoma. Still, only one drug for targeted immunotherapy of neurob...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Liu J, Li J, He M, Zhang GL, Zhao Q Abstract BTLA/HVEM (B and T lymphocyte attenuator/herpes virus entry mediator) pathways play a critical role in T cell suppression in tumor. However, its dynamic changes in different T cell subsets in peripheral blood and their clinical significance are largely unclear in cancer patients. In the current study, we showed distinct changes of BTLA and HVEM expressions on peripheral blood CD4+ and CD8+ T cells in patients with hepatocellular carcinoma (HCC); BTLA expression were significantly upregulated on circulating CD4+ but not CD8+ T cells. In sharp contrast, the levels...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Choi YJ, Park HJ, Park HJ, Jung KC, Lee JI Abstract Peripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respect to islet graft rejection in a nonhuman primate model of islet transplantation. DP T cells were functionally equivalent to conventional CD4 and CD8 T cells in terms of helper and cytotoxic activity, respectively. DP T cells expressed high le...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Wells JL, Pasternak SH PMID: 30119059 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
ConclusionHowever, a fully and systematically discussion of the methods of detoxification for aflatoxins is still not available. Therefore, in the present review we briefly enumerate several traditional strategies, update newly methods, particularly the potential use of natural phytochemicals, and discuss some mechanisms during the detoxification period, summarizing merits and demerits of these methods. We suggest that this important information and our humble opinions could help researchers to understand the degradation of methods for aflatoxins.Graphical abstract
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 18 August 2018Source: Food HydrocolloidsAuthor(s): Wenmeng He, Wei Zhao, Ruijin YangAbstractA by-product of wheat wet processing, wheat gluten (WG) exhibits low solubility, which restricts its application as an emulsifier and a stabilizer in oil-in-water emulsions. WG modified by acetic acid, tartaric acid, and citric acid deamidation combined with heat treatment, can improve the solubility, surface hydrophobicity, as well as the emulsifying and foaming properties of the modified WGs (MWGs). The principal component analysis suggested the emulsifying and foaming properties of the citric ac...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
More News: Alzheimer's | Brain | Breast Cancer | Cancer | Cancer & Oncology | Cardiology | Conferences | CT Scan | Environmental Health | Heart | Hormones | Infectious Diseases | Neurology | Neuroscience | PET Scan | Prostate Cancer | Science | Stroke | Study | Toxicology | Washington University