Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients

Haptoglobin (Hp) functions as an antioxidant by binding with haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants ...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Conclusions: Compared with 1996, participants entering CR in 2015 were older, more overweight, and had a higher prevalence of coronary risk factors. Lipid values improved substantially concurrent with increased statin use. While the percentage of female participants increased, they continue to be underrepresented. Patients with heart valve repair/replacement now constitute 10.6% of the patients enrolled. Clinical programs need to recognize changing characteristics of attendees to best tailor interventions.
Source: Journal of Cardiopulmonary Rehabilitation - Category: Rehabilitation Tags: Cardiac Rehabilitation Source Type: research
CONCLUSIONS: When switching DPP-4Is because of insufficient efficacy, consideration of their DPP-4 binding site may be beneficial.
. PMID: 31232277 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
ConclusionsThe presence of improved dietary related quality of life was described by some participants. While not all individuals were seen to move into the Realizing phase after initiating an SGLT-2 inhibitor, there appears to be an opportunity to create behaviour change following positive Reckoning experiences.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionThis study demonstrated that FOAE inhibited activity of digestive enzymes and exhibited antioxidant, anti-inflammatory and antihyperglycemic activity in STZ-nicotinamide prompted diabetic rats and suggested that FOAE might be used as a therapeutic agent for the management of type-2 diabetes.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: September 2019Source: Biomedicine &Pharmacotherapy, Volume 117Author(s): Quantao Ma, Yaqi Li, Pengfei Li, Min Wang, Jingkang Wang, Ziyan Tang, Ting Wang, Linglong Luo, Chunguo Wang, Ting Wang, Baosheng ZhaoAbstractType 2 diabetes mellitus (T2DM) is a common clinical chronic disease, while its pathogenesis is still inconclusive. Intestinal flora, the largest micro-ecological system in the human body, is involved in, meanwhile has a major impact on the body's material and energy metabolism. Recent studies have shown that in addition to obesity, genetics, and islet dysfunction, the disturbance of intesti...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Kenneth J Bender, PharmD, MA An investigational agent with dual mechanisms of action demonstrated benefit on markers of both diabetes and non-alcoholic steatohepatitis (NASH), in studies presented at the American Diabetes Association (ADA) Scientific Sessions meeting in San Francisco, CA June 7-11.
Source: ConsultantLive - Category: Internal Medicine Tags: Diabetes Type 2 Source Type: news
ADA 2019 ICYMI: Safety and efficacy of oral semaglutide in patients with T2DM was demonstrated in results of 3 PIONEER program clinical trials.   Highlights, here.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Diabetes Diabetes Type 2 Source Type: news
Epidemiological data suggest an increased risk of developing Alzheimer’s disease (AD) in individuals with type 2 diabetes (T2D). AD is anatomically associated with an early progressive accumulation of A leading to a gradual Tau hyperphosphorylation, which constitute the main characteristics of damaged brain in AD. Apart from these processes, mounting evidence suggests that specific features of diabetes, namely impaired glucose metabolism and insulin signaling in the brain, play a key role in AD. Moreover, several studies report a potential role of A and Tau in peripheral tissues such as pancreatic cells. ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 24 June 2019Source: Saudi Journal of Biological SciencesAuthor(s): Manal Abudawood, Hajera Tabassum, Mir Naiman Ali, Basmah Almaarik, Mohrah Alshaikh, Anas Dhaifallah AlGhamdi, Johara Yahya AlFaifi, Khalil Ibrahim Softa, Samia Sobki, Ali AljohiAbstractType 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stres...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
TYPE 2 diabetes is a life-long condition that requires close monitoring and a number of lifestyle changes to prevent serious health risks. One simple exercise can help to keep it under control - have you tried this?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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