Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models
Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters ...
CONCLUSIONS: TC is a special subtype of suprasellar craniopharyngioma, which is remarkably different from NC. Identification of this type of tumor preoperatively is essential for the planning of appropriate surgical approach and degree of excision. PMID: 31200374 [PubMed - as supplied by publisher]
CONCLUSIONS: In this study, we found that O-GlcNAcylation of HDAC4 at Ser-642 is cardio-protective in diabetes and counteracts pathological CaMKII signaling. We introduce a molecular model explaining how diabetic metabolism possesses important cardio-protective features besides its known detrimental effects. A deeper understanding of the here-described PTM crosstalk may lay the ground for the development of specific therapeutic concepts to treat heart failure in the context of diabetes. PMID: 31195810 [PubMed - as supplied by publisher]
Conclusion: Our results suggest that AAT is internalized by β cells through clathrin-mediated endocytosis that leads to the suppression of caspase 9 activation. This process is required for the protective function of AAT in islets when challenged with proinflammatory cytokines or after islet transplantation.
We report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Gu érin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer recurrence. She was started on nivolumab treatment, and complete response was achieved for one year. However, during this time, she was diagnosed with superficial bladder cancer and underwent surgery but experienced recurrence. After one month of intravesical BCG instillation, the patient developed acute-onset type 1 diabe...
ConclusionThe renal threshold for glucose reabsorption in patients with T1DM was near the normal range and significantly lower than that in patients with T2DM. The efficacy of the SGLT2 inhibitor was better in patients with a higher renal threshold for glucose reabsorption. Thus, these results indicate that it is advisable to estimate the renal threshold for glucose reabsorption prior to initiating SGLT2 inhibitor therapy in patients with T1DM.
ConclusionTea, especially black tea, could be considered a potential therapeutic agent against type 1 diabetes ‐induced intestinal Na+/K+‐ATPase disturbance to control postprandial hyperglycemia.This article is protected by copyright. All rights reserved
Abstract Diabetic Nephropathy (DN) is the most common cause of end-stage renal disease associated with high mortality worldwide. Increase in iron levels have been reported in the diabetic rat kidneys as well as in the human urine of diabetic patients. In addition, low iron diet or iron chelators delay DN progression in diabetic patients and in animal models of diabetes. Possible maladaptive mechanisms of organ damage by tissue iron accumulation have not been well studied. We recently reported that iron induced retinal renin angiotensin system (RAS) and accelerated the progression of diabetic retinopathy. However, ...
Large international study explores role of dulaglutide Related items fromOnMedica Statin use link to heightened type 2 diabetes risk in some people Diabetes prescriptions rise by a third in last five years US expert group updates statins recommendations Drug could cut heart events by 26% in diabetics Metformin doesn ’t help HbA1c in teens with type 1 diabetes
Drug delays diabetes onset a median of 2 years Related items fromOnMedica Statin use link to heightened type 2 diabetes risk in some people Type 2 diabetes drugs vary in impact on survival NICE approves extra ‘triple therapy’ drug for diabetes Study claims medical treatment can reverse type 2 diabetes Drug could cut heart events by 26% in diabetics
CONCLUSIONS: We report concomitant endocrine disease in 7.76 % of our 708 SLE cohort followed, for almost 40 years, at UCLH. These patients have increased liability to develop a second endocrine disease, but overall there is no difference in terms of mortality between SLE patients with or without an endocrinopathy. It is important to capture endocrine diseases in SLE as the symptoms they cause may mimic SLE features, but require quite distinct treatment. PMID: 31172923 [PubMed - as supplied by publisher]