Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity
Conclusions The decrease in functional connectivity between sensory and motor cortices, despite an increase in local spectral power, suggests that propofol causes a functional disconnection of cortices with increases in autonomous activity within cortical regions. This pattern occurs across diseases evaluated, suggesting that these may be generalizable effects of propofol in patients with movement disorders and beyond. Sensorimotor network disruption may underlie anesthetic-induced loss of volitional control.
Publication date: July–August 2019Source: Brain Stimulation, Volume 12, Issue 4Author(s): Simon Daniel Israeli-Korn, Tsviya Fay-Karmon, Steven Tessler, Gilad Yahalom, Sandra Benizri, Hanna Strauss, Zion Zibly, Roberto Spiegelmann, Sharon Hassin-BaerAbstractBackgroundPeople with Parkinson's disease (PD) treated with deep brain stimulation (DBS) with non-rechargeable implantable pulse generators (IPGs) require elective IPG replacement operations involving surgical and anesthesiologic risk. Life expectancy and the number of replacements per patient with DBS are increasing.ObjectiveTo determine whether IPG longevity is i...
Conclusions: Our study confirmed that STN localization with microelectrode recording and patient comfort could be achieved based on equal effectiveness and safety of STN-DBS under GA compared with LA. PMID: 30800263 [PubMed]
People with Parkinson's disease (PD) treated with deep brain stimulation (DBS) with non-rechargeable implantable pulse generators (IPGs) require elective IPG replacement operations involving surgical and anesthesiologic risk. Life expectancy and the number of replacements per patient with DBS are increasing.
The authors present their experiences with an alternative anesthesia technique for deep brain stimulation surgery for Parkinson's disease patients who cannot tolerate conscious sedation.BMC Anesthesiology
The Substantia Nigra pars reticulata (SNr) is a promising target for deep brain stimulation (DBS) to treat the gait and postural disturbances in Parkinson ’s Disease (PD). The effects of DBS in subregions of the SNr on the treatment of gait and postural disturbances in PD is not clear. We recorded neural activity in subregions of SNr using tungsten microwire electrodes in anesthetized rats and hypothesized that changes in coherence spectra between n eighboring microelectrode recordings correlated with electrode position within subregions of the SNr, i.e., lateral SNr and medial SNr.
In order to reach the research goals, 28 individuals with Parkinson's disease under deep brain stimulation were randomly assigned into two groups including Dexmedetomidine and Propofol that referring to Shohada Tajrish Hospital in 2016 . The following drugs were used: Dexmedetomidine with dose of 0.2-0.4 μ/kg/h and Propofol with doses of 20-30 mg bolus, and then 10-20 μ/kg/min infusion, with a control and preservation of BIS between 65 and 85. The total dose of local anaesthetic drugs was recorded at the end of the procedure.
Conclusion: Medically intractable tremor treated with laser interstitial thermal thalamotomy may be a useful addition to the treatment armamentarium for medically intractable tremor disorders. © 2018 International Parkinson and Movement Disorder Society
Conclusion: GPi and GPe are distinguishable using LFP spectral profiles in the awake condition. Propofol obliterates this spectral differentiation. Therefore, LFP spectra cannot be relied upon in the propofol-anesthetized state for functional mapping during DBS implantation.Stereotact Funct Neurosurg
CONCLUSIONS In PD patients, bilateral GPi and STN DBS using the asleep method resulted in motor, quality-of-life, and medication reduction outcomes that were comparable to those of the awake method. PMID: 29547091 [PubMed - as supplied by publisher]
Abstract Deep Brain Stimulation applied at high frequency (HFS) to the subthalamic nucleus (STN) is used to ameliorate the symptoms of Parkinson's disease. The mechanism by which this is achieved remains controversial. In particular, it is uncertain whether HFS has a suppressive or excitatory action locally within the STN. Brief exposure of rats to ether anaesthesia evokes pathological burst firing and associated expression of the immediate early gene c-Fos in STN neurons. We used this ether model of STN activation to test the effect of a range of HFS parameters on c-Fos expression evoked by the anesthetic. The el...