Effect of Remote Ischemic Preconditioning on Systemic Toxicity and Ototoxicity Induced by Cisplatin in Rats: Role of TNF- α and Nitric Oxide

Background/Aims: Cisplatin is a chemotherapeutic agent. The use of remote ischemic preconditioning (RIPC) was proposed after the observation that ischemic preconditioning of a cardiac vascular area could protect another completely distinctly.Methods: This is an experimental study. Male Wistar rats were anesthetized, and they underwent a hearing evaluation via measurement of the brainstem auditory evoked potential (BSAEP). Then, cisplatin was administered intraperitoneally (IP) at a dose of 8 mg/kg/day for 4 consecutive days to group 1, whereas saline solution was administered IP to group 2. In groups 3 and 4, ischemia of the right hind paw was performed for 10 min, followed by reperfusion for 30 min, after which cisplatin or saline was administered IP to group 3 or group 4, respectively. Afterwards, all animals were evaluated via the BSAEP. The right cochlea was dissected for immunohistochemistry.Results: RIPC lowered the increase in BSAEP of the animals treated with cisplatin (p = 0.0146). Weight loss decreased in the animals subjected to RIPC (p
Source: ORL - Category: ENT & OMF Source Type: research

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CONCLUSIONS: Based on the literature, best practice guidelines, and a cost analysis, it was decided that patients undergoing routine cataract surgery in Edmonton Zone Hospitals under regional anaesthesia would no longer require physician history and physicals and ECGs. Elimination of the preoperative requirements for all but select high-risk patients meant that 100% of patients who arrived for cataract surgery would not have outstanding presurgery requirements. PMID: 31109469 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Publication date: Available online 22 May 2019Source: Nitric OxideAuthor(s): Christopher P. Hopper, Jakob Wollborn
Source: Nitric Oxide - Category: Chemistry Source Type: research
Just a few links and references for those CV Anesthesiologists and residents thinking about CV Anesthesia. We should keep pushing the boundaries and our role into the cath lab. When I was a resident all I was told is that no one wants to do anesthesia cases in "offsite" locations. Well here we are - In my opinion, in addition to the ICU, the saving grace for anesthesiologists in a novel way to add value... Interventional Echocardiography CV Anesthesia
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
Condition:   Anxiety Intervention:   Sponsor:   Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Anesthesia, Spinal Intervention:   Sponsor:   Bozyaka Training and Research Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 22 May 2019Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Amit Kumar Sahu, Prasandeep Rath, Bharat AggarwalAbstractUltrasound guided musculoskeletal injection has a wide range of indication in joint, muscle, tendon, nerve, ganglion and bursa pathologies. These are less invasive procedures and provide desirable results in short duration. Local anesthetics and corticosteroids are the most commonly injected pharmaceuticals. Platelet rich plasma and autologus blood injections have gained popularity in recent past and provide acceptable results. In this article we aim to review ...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Prospective applicants frequently ask us whether their application ideas fit within our mission. NIGMS supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. We also support research in some specific clinical areas that affect multiple organ systems, including anesthesia, sepsis, wound healing, and trauma. In addition, we’re committed to training the next generation of scientists, enhancing the diversity of the scientific workforce, and developing research capacity throughout the country. Not all applic...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - Category: Biomedical Science Authors: Tags: Funding Opportunities Research Administration Preparing an Application Source Type: blogs
Ketamine was once used mainly as an anesthetic on battlefields and in operating rooms. Now this medication is gaining ground as a promising treatment for some cases of major depression, which is the leading cause of disability worldwide. In the US, recent estimates show 16 million adults had an episode of major depression in the course of a year. Suicide rates rose substantially between 1999 and 2016, increasing by more than 30% in 25 states. Because of its rapid action, ketamine could have a role to play in helping to prevent suicide. Why is ketamine exciting for treating depression? If a person responds to ketamine, it c...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Health Health trends Mental Health Source Type: blogs
Publication date: Available online 21 May 2019Source: American Journal of OtolaryngologyAuthor(s): Yuce Islamoglu, Gulın Gokcen Kesici, Kadır Sınası Bulut, Ebubekır Alper Ozer, Yagmur Teleke Canan, Mehmet Ali BabademezAbstractIntroductionİnferior turbinate hypertrophy is a common reason of nasal obstruction. One of the most preferred surgical metod is radiofrequency tecnique. Coblation submucosal reduction turbinator (SCT);new surgical device; started to use recently. Since the method is new, very few study has been done yet. We compare coblation radiofrequency (CR) with SCT.Material and methodsPatients with only inf...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: Available online 22 May 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Hala S. Abdel-Ghaffar, Amani H. Abdel-Wahab, Mohammed M. Roushdy, Amira M.M. OsmanAbstractObjectivesThe administration of ketamine as nebulized inhalation is relatively new and studies on nebulized ketamine are scarce. We aimed to investigate the analgesic efficacy of nebulized ketamine (1 and 2 mg.kg−1) administered 30 min before general anesthesia in children undergoing elective tonsillectomy in comparison with intravenous ketamine (0.5 mg.kg−1) and saline placebo.MethodsOne hun...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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