What Risks for Radiation in Scleroderma Patients with Breast Cancer? (CME/CE)

(MedPage Today) -- Acute toxicity and disease flares were rare
Source: MedPage Today Radiology - Category: Radiology Source Type: news

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We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins. While on chloroquine she developed extensive classic vitiligo. It is not clear if this is another feature of her complex and unusual PCT, or a consequence of her antimalarial therapy.Case Rep Dermatol 2018;10:115 –121
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
ConclusionsThe effect of MLD on the HRQoL of patients with chronic oedema is unclear.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionThese data suggest that radiation injury causing local tissue fibrosis is not inevitable in SSc patients with breast cancer, occurring in ~50% of cases without evidence of lung or generalized skin disease flare. Therefore, the use of RT for breast cancer is considered an option based on the informed patient's preference.This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Our results suggest that scleroderma and dermatomyositis autoantibodies are cancer biomarkers only in patients with clinical manifestations of specific rheumatic diseases and are unlikely to improve risk stratification for cancer in the general population. However, prospective studies are needed to examine whether scleroderma and dermatomyositis autoantibodies are markers of malignancy in other cancer types. PMID: 28628466 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
June ‚Äčis the month for more than 10 disease-related awareness campaigns, including Myasthenia Gravis Awareness Month, National Congenital Cytomegalovirus Awareness Month and National Scleroderma Awareness Month. It also hosts a handful of awareness weeks and days, ranging from Helen Keller Deaf-Blind Awareness Week to World Sickle Cell Day. June’s awareness list is shorter than most, but every month is full of diseases and disorders to take note of. You probably haven’t heard of half of them, and you’re not alone. So what’s the point of an awareness day, week or month? To understand the chall...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
AbstractPurpose of ReviewThis review provides a summary of recent insights into the role of the local white adipose tissue (WAT) in systemic sclerosis.Recent FindingsAdipocytes located in an interfacial WAT area adjacent to fibrotic lesions have an intermediate phenotype and special properties implicated in fibrotic pathology in systemic sclerosis (SSc). The important role of these cells is recognized in different pathologies, such as wound healing, psoriasis, breast cancer, and prostate cancer. Additionally, both immature and mature adipocytes are involved in the appearance of fibroblast-like cells but exhibit different p...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Shrenik Balegar, Dharmendra Kumar Mishra, Sagarika Chatterjee, Shweta Kumari, Anup Kumar TiwaryIndian Journal of Dermatology 2016 61(5):581-581 Morphea is a localized scleroderma variety which can be circumscribed or generalized and is characterized by sclerotic plaques developing on trunk and limbs. Surgery and radiation have been implicated as etiological factors for the development of morphea. Majority of the radiation-induced morphea cases have occurred in patients with breast cancer. The affected areas have been generally restricted to the area of radiation and nearby surrounding area in most of the reported cases. W...
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
It was a story with a bit of irony, as well as ominous health warnings. Crystal Hefner, the 30-year-old wife of Playboy magazine mogul Hugh Hefner, announced in a story in People magazine last month that she'd had her breast implants removed because they were making her sick. Hefner posted a photo of her post-surgery self on Instagram with the caption, "Using 2016 to reclaim my health and embrace and love myself for the real me." The former model, now a DJ, was diagnosed a few months back with Lyme disease. Her symptoms included intolerance to foods and beverages as well as back, neck, and shoulder pain. Hefn...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
AbstractRadiotherapy is a critical component in the treatment of breast cancer, which is the leading cause of cancer death in women. Morphea, or localized scleroderma, is a rare dermatologic disorder characterized by dermal fibrosis and collagen deposition. Most cases of Morphea arise de novo. The aetiology is poorly understood but there are increasing cases in the literature of radiation-induced morphea (RIM) following external beam radiotherapy in breast cancer patients. Its development has functional and cosmetic consequences. Treatment options are limited, with few reports of successful surgical management or formal br...
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Abstract Generalized morphea is a rare idiopathic form of scleroderma that literally means "hard skin." Morphea is usually considered an isolated event that is not associated with malignancy. However, case reports of lung, hematologic, and breast cancer occurring simultaneously with large plaque morphea have caused dermatologists to question whether a work-up for malignancy is appropriate. We highlight a case of generalized morphea that preceded invasive ductal carcinoma of the breast and provide a discussion about the possible paraneoplastic origin of generalized morphea and systemic sclerosis (SSc). ...
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research
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