Medical News Today: Types of zoonotic diseases

Zoonosis or zoonotic diseases are conditions that can be passed from animals to humans. These include rabies, malaria, and Lyme disease. Learn more.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Public Health Source Type: news

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Publication date: Available online 18 May 2019Source: Journal of Herbal MedicineAuthor(s): Richard Komakech, Youngmin KangAbstractMedicinal plants have been an integral part of the healthcare system for centuries. Prunus africana, an evergreen plant of the family Rosaceae in sub-Saharan Africa, has been used to treat numerous diseases and disorders since time immemorial. Over the past decades, several ethnomedicinal surveys were conducted in many communities across Africa which validated the use of P. africana in traditional medicine. The increased interest in P. africana across the globe has led to several pharmacological...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Authors: Figoni J, Chirouze C, Hansmann Y, Lemogne C, Hentgen V, Saunier A, Bouiller K, Gehanno JF, Rabaud C, Perrot S, Caumes E, Eldin C, de Broucker T, Jaulhac B, Roblot F, Toubiana J, Sellal F, Vuillemet F, Sordet C, Fantin B, Lina G, Gocko X, Dieudonné M, Bodaghi B, Gangneux JP, Degeilh B, Partouche H, Lenormand C, Sotto A, Raffetin A, Monsuez JJ, Michel C, Boulanger N, Cathebras P, Tattevin P, endorsed by scientific societies Abstract Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevent...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
In this study, we employed a multipurpose fusion tag to improve the production of PfPMV in E. coli. Recombinant PfPMVm, comprising residues 84 to 521, was substantially obtained in soluble form and could be purified in a single step, yielding a 3.7-fold increase in purified PfPMVm compared to previous reports. Additionally, we have mutated the catalytic residues (D118 N and D365 N), individually and together, and the unpaired cysteine residue C178 to evaluate the effects on catalytic efficiency. Mutation of D365 had more pronounced effects on the catalytic efficiency than that of D118, suggesting that the D36...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
In this study we have generated several non-conform vaccine lots by an excessive inactivation with β-propiolactone (BPL) and assessed the capacity of both tests to detect the corresponding consequences. Excessive BPL inactivation causes G-protein unfolding, altering in turn viral morphology and the continuity of the G-protein layer in the viral particle. Both the NIH and the ELISA tests were able to monitor the consequences of excessive inactivation in a similar manner. Of note, the experimental error of the ELISA test was well below that of the NIH test. These results increase the prospect that the ELISA test could b...
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 17 May 2019Source: Journal of Molecular BiologyAuthor(s): Nichole D. Salina, Wai Kwan Tang, Niraj H. ToliaAbstractPlasmodium parasites are the causative agent of malaria, a disease that kills approximately 450,000 individuals annually, with the majority of deaths occurring in children under the age of five and the development of a malaria vaccine is a global health priority. Plasmodium parasites undergo a complex life cycle requiring numerous diverse protein families. The blood stage of parasite development results in the clinical manifestation of disease. A vaccine that disrupts the bloo...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
kamoto Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus. HEV can cause both acute and chronic hepatitis, with the latter usually occurring in immunocompromised patients. Modes of transmission range from the classic fecal–oral route or zoonotic route, to relatively recently recognized but increasingly common routes, such as via the transfusion of blood products or organ transplantation. Extrahepatic manifestations, such as neurological, kidney and hematological abnormalities, have been documented in some limited cases, typically in patients with immune suppression. HEV has demonstrated ext...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Abstract Malaria infection threatens millions of people worldwide. Sequestering of Plasmodium-infected erythrocytes within the blood vessels of the brain may lead to a more severe form of disease called cerebral malaria (CM), which is difficult to diagnose and treat. Here we used C57BL/6 mice to establish a model of experimental CM (ECM). Comparing the dosage dependence of ECM induction, we found that inoculation with 1×103 parasitized erythrocytes had higher efficiency at establishing ECM than 1×106 parasitized erythrocytes. However, the percentage of ECM varied in different experimental batches. Infe...
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
For the 16 years that Dr. Brian Westerberg, a Canadian surgeon, worked volunteer missions at the Mulago National Referral Hospital in Kampala, Uganda, scarcity was the norm. The patients usually exceeded the 1,500 allotted beds. Running water was once cut off when the debt-ridden hospital was unable to pay its bills. On some of his early trips, Westerberg even brought over drugs from Canada in order to treat patients. But as low-cost generics made in India and China became widely available through Uganda’s government and international aid agencies in the early 2000s, it seemed at first like the supply issue had been ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized generic drugs medication medicine Source Type: news
[East African] Scientists in Tanzania have discovered that a species of malaria can live in the body for decades without showing any clinical signs, but still manage to contribute to the transmission of malaria in the country.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Michelle Johnston Funtabulously Frivolous Friday Five 280 Michelle Johnston tosses away the papyrus and pulls out the parchment in this week's Funtabulously Frivolous Friday Five on the subject of Shakespeare and Medicine.
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: FFFF Literary Medicine Ague Julius Caesar King's Evil malaria Shakespeare Tetter Thersites William Shakespeare Source Type: blogs
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