Music Therapy Offers an End-of-Life Grace Note
Music therapy is becoming more common in nursing homes and hospices, where it has been shown to improve a patient ’ s quality of life.
Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7.5 yr afterwards. Importantly, other studies have identified that the incidence of cognitive change is similar after non-cardiac surgery. ...
Publication date: February 2019Source: Journal of Neurolinguistics, Volume 49Author(s): Javier Rodríguez-Ferreiro, Carmen Martínez, Fernando CuetosAbstractAlzheimer's disease (AD) patients are known to present semantic memory impairments, and semantic processing plays a crucial role in the formation of false memories. We assessed 40 early stage AD patients and 35 matched healthy volunteers with an emotional version of the Deese-Roediger-McDermott paradigm, which allows the study of false memory formation. Participants were presented with three negative, three neutral and three positive lists of words, each se...
(MedPage Today) -- News and commentary from the world of neurology and neuroscience
Publication date: Available online 15 October 2018Source: Alzheimer's &DementiaAuthor(s): Kwangsik Nho, Alexandra Kueider-Paisley, Siamak MahmoudianDehkordi, Matthias Arnold, Shannon L. Risacher, Gregory Louie, Colette Blach, Rebecca Baillie, Xianlin Han, Gabi Kastenmüller, Wei Jia, Guoxiang Xie, Shahzad Ahmad, Thomas Hankemeier, Cornelia M. van Duijn, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, P. Murali Doraiswamy, Andrew J. SaykinAbstractIntroductionBile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests gut microbi...
ConclusionThe findings of the present study revealed the significant neuroprotective actions of Vitis vinifera by modifying the biochemical parameters and inhibited the mRNA expression of Amyloid Precursor Protein and Tau, which are the key pathological hallmarks of Alzheimer’s disease, which was further confirmed by histopathological observations.Graphical abstract
A new study shows that, despite safety concerns, half of AD patients are being treated with psychotropic meds for behavioral symptoms, with 1 in 5 taking two or more.Medscape Medical News
DISCUSSION: Our results support the model that in the presence of AD pathology, SCD corresponds to the late preclinical stage (stage 2 of AD) with smaller MTL volumes. PMID: 30321506 [PubMed - as supplied by publisher]
DISCUSSION: ADNI publications from 2016 and 2017 supported the idea of AD as a multifactorial disease and provided insights into the complexities of AD disease progression. These findings guided the development of novel biomarkers and suggested that subject selection on the basis of multiple factors may lower AD clinical trial costs and duration. The use of multiple concurrent therapies in these trials may prove more effective in reversing AD disease progression. PMID: 30321505 [PubMed - as supplied by publisher]
DISCUSSION: These findings provide new insights into the molecular mechanisms of AD pathogenesis and thus pave a way for developing novel therapeutics for AD by targeting AD specific cell cycle networks and drivers. PMID: 30321504 [PubMed - as supplied by publisher]
DISCUSSION: LTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline. PMID: 30321503 [PubMed - as supplied by publisher]