Growth factor independence 1b. A key player in the genesis and maintenance of acute myeloid leukaemia and myelodysplastic syndrome.

Growth factor independence 1b. A key player in the genesis and maintenance of acute myeloid leukaemia and myelodysplastic syndrome. Haematologica. 2018 Jan 11;: Authors: Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C, no Abstract Differentiation of haematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factors function can be the basis of (pre)malignancies such as myelodysplastic syndrome or acute myeloid leukaemia. Growth factor independence 1b is a repressing transcription factor regulating quiescence of hematopoietic stem cellss and differentiation of erythrocytes and platelets. Here, we show that low expression of Growth factor independence 1b in blast cells is associated with an inferior prognosis of myelodysplastic syndrome and acute myeloid leukaemia patients. Using different models of human myelodysplastic syndrome or acute myeloid leukaemia, we demonstrate that acute myeloid leukaemia development was accelerated with heterozygous loss of Growth factor independence 1b, and latency was further decreased when Growth factor independence 1b was conditionally deleted. Loss of Growth factor independence 1b significantly increased the number of leukaemic stem cells with upregulation of ge...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research