Association of Physicians of India: Position Statement on Role of Chirally Pure Molecules in Clinical Practice.

Association of Physicians of India: Position Statement on Role of Chirally Pure Molecules in Clinical Practice. J Assoc Physicians India. 2017 Dec;65(12):49-60 Authors: Nadkar MY, Tiwaskar M, Kalra S, Shah SN, Bansode BR, Dutta A, Bajaj S, Aggarwal S, Balhara YPS, Das AK, Dhamija P, Gupta YK, Jacob J, Mishra S, Narasingan SN, Ponde CK, Prabhoo R, S B, Sahay M, Sahay RK, Sathyamurthy I, Tiwaskar S, Vora A Abstract Chirally pure molecules or enantiomers are non-superimposable mirror images of each other with a chiral center (such as carbon, sulphur, nitrogen or phosphorous atom). An equimolar mixture of enantiomers forms a racemate. Chirally pure molecules (single enantiomers) are important in the field of drug discovery as the drug targets such as enzymes and receptors are enantioselective in nature. Clinical studies have demonstrated that chirally pure drugs exhibit different pharmacokinetic and metabolic profiles, reduced adverse events, improved safety profiles and similar therapeutic activity at lowered drug dosage as compared with the racemate in many therapeutic areas. However, since there is a low level of awareness on the advantages of chirally pure molecules among clinicians, pharmacists and patients in India, the Association of Physicians of India (API) developed this position statement to increase awareness on the concept of chirality and the associated advantages of using chirally pure drugs in certain therapeutic areas to...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research