A multidimensional assessment of the burden of psoriasis: Results from a multinational dermatologist and patient survey.

CONCLUSION: Psoriasis patients with physical and psychological comorbidities, itch and, affected visible and sensitive body areas had lower QoL, and greater work impairment compared to those without these conditions. This article is protected by copyright. All rights reserved. PMID: 29328510 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Conclusions: Women with deep invasive endometriosis who underwent IVF do not seem to be exposed to a substantially increased risk of recurrence/disease progression. Larger evidence from independent groups is however required for a definitive conclusion. PMID: 31517304 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Conclusions: A wide variety of analgesia protocols are used. The three most frequently used are i.v. administered opioids, i.m. administered opioids, and non-sedative oral analgesics. The variety of analgesia protocols is not desirable in the context of good clinical practice, and considering the risks of combining opioids and benzodiazepines. Monitoring of vital functions was only performed after administration of i.v. medication. A comparison of the pain scores could be a first step in finding the optimal method of analgesia, thereby forming the basis of guidelines for analgesia during oocyte retrieval. PMID: 31517299 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
In this study, a smartphone camera using an image-based colorimetric detection method was successfully developed for quantitative analysis of urine glucose. A horseradish peroxidase-hydrogen peroxide-3,3'5,5'-tetramethylbenzidine (HRP-H2O2-TMB) system was optimized for a reliable and gradual color fading process via a glucose oxidase (GOD) catalyzed oxidation reaction. The color changes of the peroxidase-H2O2 enzymatic reactions in the 96-well microplate were captured by a smartphone RGB camera with subsequent detection of red, green, and blue (RGB) intensities decreasing at each image pixel. The highly quantitative relati...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract This work presents a reliable analytical procedure combining micro-extraction by packed sorbent (MEPS) and ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry to determine 8-iso prostaglandin F2α, 8-iso prostaglandin E2 and prostaglandin E2 in dried blood spots (DBSs). To reach this goal, we optimized a fast semi-automated MEPS procedure for the clean-up and pre-concentration of the analytes extracted from a single DBS (50 μL) by a 70:30 v/v methanol:water mixture. Limits of detection of about 20 pg mL-1, satisfactory recoveries (90-110%) and very g...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract MicroRNAs (miRNA) involve in regulating different physiological processes whose dysregulation is associated with a wide range of diseases including cancers, diabetes and cardiovascular problems. Herein, we report a direct, sensitive and highly selective detection assay for circulating microRNA (miRNA). This detection strategy employs magnetic nanoparticles as the reaction platform which can not only allow online pre-concentration and selective separation but also integrates ligation reaction with amplification to enhance the sensitivity of the detection assay. With the presence of the target miRNA, the lo...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR.
Source: Neuroscience Research - Category: Neuroscience Source Type: research
ConclusionsEDA aggravates steatosis by striking balance between lipid deposition and elimination. It was a potential biomarker of NAFLD.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
SYNDROMES OF KETOSIS-PRONE DIABETES. Trans Am Clin Climatol Assoc. 2019;130:145-155 Authors: Balasubramanyam A Abstract Ketosis-prone diabetes (KPD) is a heterogeneous condition characterized by patients who present with diabetic ketoacidosis but lack the phenotype of autoimmune type 1 diabetes. Here I review progress in our understanding of KPD and its place in the expanding universe of "atypical diabetes." I focus on investigations of our collaborative research group at Baylor College of Medicine and the University of Washington using a longitudinally followed, heterogeneous, multiethnic co...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
CONCLUSION: The diabetic trained rats demonstrate a protective effect of resistance training on the serum lipid profile. PMID: 31517608 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
CONCLUSION: Our results show that under hyperglycemic condition, expression of genes involved in the miRNA maturation was significantly increased in HUVECs. Upregulation of these genes may have role in diabetic complications through the dysregulation of the miRNA expression. PMID: 31517606 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
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