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The neurophysiological and evolutionary considerations of close combat: A modular approach.

The neurophysiological and evolutionary considerations of close combat: A modular approach. Hell J Nucl Med. 2017 Sep-Dec;20 Suppl:162 Authors: Dervenis K, Tsialogiannis E Abstract Close Combat may be identified as a physical confrontation involving armed or unarmed fighting, lethal and/or non-lethal methods, or even simply escape from and/or de-escalation of the confrontation. Our model hypothesizes that distinct areas of the brain are utilized for specific levels of violence, based on evolutionary criteria, and that these levels of violence bring into effect distinct physiological criteria and kinesiology. This model is outlined similar to Paul D. MacLean's triune brain theory, but incorporates distinct processes inherent to the autonomic nervous system (i.e. a "quadrune brain"), and correlates the observed level of violence to a particular response to a specific neural complex associated with very specific reactive kinesiology in the body. Our hypothesis is that the reverse also holds true: specific movements, scenarios and breathing will "activate" corresponding neural centres that in turn correlate to a respective level of violence. Moreover, socio-historic records bear out the premise that specific behavioural violations of social protocols act as "triggers" for assaultive and lethal force involving weapons, and it is very likely that these triggers (and the concomitant decision to engage in assault or lethal force) are...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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Background: TheIL10 family of genes includes crucial immune regulators.We tested the hypothesis that single nucleotide polymorphisms (SNPs) inIL10,IL19,IL20, andIL24 of theIL10 family gene cluster alter the clinical outcome of septic shock.Methods: Patients with septic shock (n = 1,193) were genotyped for 13 tag SNPs ofIL10,IL19,IL20, andIL24.IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped forIL20 rs2981573 A/G. The primary outcome variable was 28-day mortality.Results: Patients with the G allele of IL20 rs2981573 had a significantly incre...
Source: Journal of Innate Immunity - Category: Allergy & Immunology Source Type: research
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