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Stem cells therapy: the future in the management of systemic sclerosis? A case report.

CONCLUSION: Application of isolated adipose tissue-derived stem cells seems to be a very promising procedure in the treatment of the manifestation of systemic sclerosis. However, more clinical and experimental studies are required, in order to understand the exact mechanisms of action and standardize the therapy. PMID: 29324934 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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Authors: Chen J, Luo F, Lei M, Chen Z Abstract PURPOSE: To compare the influence on the immune system of two different methods of anesthesia and analgesia in patients treated with radical resection of pulmonary carcinoma. METHODS: Thirty-four patients treated with radical resection of pulmonary carcinoma were randomly divided into two groups (group A and group B, 17 cases in each group). Patients in group A were administered total intravenous anesthesia (TIVA) without inhaled hypnotics and intravenous analgesia while patients in group B were administered TIVA combined with epidural anesthesia and epidural analg...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Authors: Karamanou M, Salakos N, Grammatikakis I, Androutsos G Abstract At the beginning of the 19th century, gynaecological cancer, mainly cancer of the uterus and cervix was a dreadful, incurable affection. However, the popularization of the three fundamentals in surgery, anesthesia, asepsis and haemostasis, ushered the golden age of operative gynaecology. During that period distinguished surgeons/gynaecologists such as Friedrich Benjamin Osiander (1759-1822), Elias von Siebold (1775-1828) and Joseph-Claude-Anthelme Récamier (1774-1852) contributed to the development of the operative techniques, providing ...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
CONCLUSION: Although elderly patients with ESCC had higher Charlson Comorbidity Index and ASA grade, they could achieve short- and long-term outcomes of MIE similar to those of nonelderly patients. PMID: 29332350 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
This study hypothesized that genetically engineered bone marrow derived mesenchymal stem cells (BMSCs) co-expressing IFN-γ and IL-10 can serve as a potential therapeutic strategy in the treatment of HCC by inhibiting cell proliferation. METHODS: Male Sprague-Dawley rats (n=5, 200-250 g) for BMSCs isolation and Nude/SCID mice (n=35,12-20g) to develop liver cancer xenograft model were used. Mice were subcutaneously injected HepG2 cell suspension on left flank. BMSCs were genetically engineered with the recombinant lentiviral vectors expressing IFN-γ and IL-10. The experiments were performed in 5 groups (phosp...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
ConclusionScleroderma patients who are double‐positive for antibodies recognizing CENP and IFI‐16 are significantly more likely to have significant digital vascular events during the course of their disease. This study provides further evidence that anti‐CENP and anti–IFI‐16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
Digital vasculopathy in systemic sclerosis (SSc) consists of a spectrum of Raynaud's phenomenon (RP), digital ulcers (DUs), critical digital ischaemia and escalation to gangrene. The complications of severe digital vasculopathy often require hospital-based management with intravenous therapies and surgery.1–3 Although gangrene is not infrequent in the clinic, data on the prevalence and implications of gangrene in patients with SSc are scarce.3–7 The DU Outcomes (DUO) Registry is a European, prospective, multicentre, observational cohort of patients with SSc and past and/or current DUs at enrolment.8–10 Th...
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Open access Letter Source Type: research
Conclusion: Scleroderma patients who are double‐positive for antibodies recognizing CENP and IFI‐16 are significantly more likely to have significant digital vascular events during the course of their disease. This study provides further evidence that anti‐CENP and anti‐IFI‐16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
Conclusion: Scleroderma patients who are double‐positive for antibodies recognizing CENP and IFI‐16 are significantly more likely to have significant digital vascular events during the course of their disease. This study provides further evidence that anti‐CENP and anti‐IFI‐16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
ObjectiveTo examine the association between anti–interferon‐inducible protein 16 (anti–IFI‐16) antibodies and clinical features of scleroderma. MethodsSera from a discovery sample of 94 patients with scleroderma and 47 healthy controls were assayed for anti–IFI‐16 antibodies by enzyme‐linked immunosorbent assay, and associations were examined using regression analyses. Since anti–IFI‐16 autoantibodies were found to be strongly associated with digital gangrene in the discovery sample, a subsequent case–control study (with subjects matched 1:1 on disease duration) was designed for furt...
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Systemic Sclerosis Source Type: research
Abstract Objective: Our aim was to examine the association between anti‐interferon inducible protein 16 (IFI16) antibodies and clinical features of scleroderma. Methods: Sera from a discovery sample of 94 scleroderma patients and 47 healthy controls were assayed for anti‐IFI16 antibodies by ELISA, and associations were examined using regression analyses. As anti‐IFI16 autoantibodies strongly associated with digital gangrene in the discovery sample, a subsequent 1:1 disease‐duration matched case‐control study was designed for further exploration. Cases were patients with scleroderma and digital gangrene, while con...
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Full Length Source Type: research
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