Stem cells therapy: the future in the management of systemic sclerosis? A case report.

CONCLUSION: Application of isolated adipose tissue-derived stem cells seems to be a very promising procedure in the treatment of the manifestation of systemic sclerosis. However, more clinical and experimental studies are required, in order to understand the exact mechanisms of action and standardize the therapy. PMID: 29324934 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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Publication date: Available online 18 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Paola D'Andrea, Marina Sciancalepore, Katerina Veltruska, Paola Lorenzon, Antonella BandieraAbstractThe biochemical properties of muscle extracellular matrix are essential for stem cell adhesion, motility, proliferation and myogenic development. Recombinant elastin-like polypeptides are synthetic polypeptides that, besides maintaining some properties of the native protein, can be tailored by fusing bioactive sequences to their C-terminal. Our laboratory synthesized several Human Elastin-Like Pol...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
In this study, we examined the effect of sevoflurane on the excitatory synaptic transmission at CA1 synapses in hippocampal slices of mice. Sevoflurane at 5% was mixed with 95% O2 and 5% CO2 and bubbled in artificial cerebral spinal fluid (0.69 mM). Extracellular recordings of the field excitatory postsynaptic potential (fEPSP) and presynaptic fiber volley (FV) were made at physiological temperature. In addition, fluorescent measurements of presynaptic Ca2+ transients were performed while simultaneously recording fEPSP. Application of sevoflurane reduced the amplitude of fEPSP (45 ± 8%, n = 5). This effect was accom...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Source Type: research
Publication date: Available online 18 October 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Gorka Orive, Edorta Santos-Vizcaino, Jose Luis Pedraz, Rosa Maria Hernandez, Julia E. Vela Ramirez, Alireza Dolatshahi-Pirouz, Ali Khademhosseini, Nicholas A. Peppas, Dwaine F. EmerichAbstractMillions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; e...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Publication date: Available online 9 March 2018 Source:Autoimmunity Reviews Author(s): Ariane L. Herrick, Andrea Murray Most patients with Raynaud's phenomenon (RP) have “benign” primary RP (PRP), but a minority have an underlying cause, for example a connective tissue disease such as systemic sclerosis (SSc). Secondary RP can be associated with structural as well as functional digital vascular changes and can be very severe, potentially progressing to digital ulceration or gangrene. The first step in management is to establish why the patient has RP. This short review discusses the role of nailfold capillaros...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionScleroderma patients who are double‐positive for antibodies recognizing CENP and IFI‐16 are significantly more likely to have significant digital vascular events during the course of their disease. This study provides further evidence that anti‐CENP and anti–IFI‐16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
Digital vasculopathy in systemic sclerosis (SSc) consists of a spectrum of Raynaud's phenomenon (RP), digital ulcers (DUs), critical digital ischaemia and escalation to gangrene. The complications of severe digital vasculopathy often require hospital-based management with intravenous therapies and surgery.1–3 Although gangrene is not infrequent in the clinic, data on the prevalence and implications of gangrene in patients with SSc are scarce.3–7 The DU Outcomes (DUO) Registry is a European, prospective, multicentre, observational cohort of patients with SSc and past and/or current DUs at enrolment.8–10 Th...
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Open access Letter Source Type: research
Conclusion: Scleroderma patients who are double‐positive for antibodies recognizing CENP and IFI‐16 are significantly more likely to have significant digital vascular events during the course of their disease. This study provides further evidence that anti‐CENP and anti‐IFI‐16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
Conclusion: Scleroderma patients who are double‐positive for antibodies recognizing CENP and IFI‐16 are significantly more likely to have significant digital vascular events during the course of their disease. This study provides further evidence that anti‐CENP and anti‐IFI‐16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Brief Report Source Type: research
ObjectiveTo examine the association between anti–interferon‐inducible protein 16 (anti–IFI‐16) antibodies and clinical features of scleroderma. MethodsSera from a discovery sample of 94 patients with scleroderma and 47 healthy controls were assayed for anti–IFI‐16 antibodies by enzyme‐linked immunosorbent assay, and associations were examined using regression analyses. Since anti–IFI‐16 autoantibodies were found to be strongly associated with digital gangrene in the discovery sample, a subsequent case–control study (with subjects matched 1:1 on disease duration) was designed for furt...
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Systemic Sclerosis Source Type: research
Abstract Objective: Our aim was to examine the association between anti‐interferon inducible protein 16 (IFI16) antibodies and clinical features of scleroderma. Methods: Sera from a discovery sample of 94 scleroderma patients and 47 healthy controls were assayed for anti‐IFI16 antibodies by ELISA, and associations were examined using regression analyses. As anti‐IFI16 autoantibodies strongly associated with digital gangrene in the discovery sample, a subsequent 1:1 disease‐duration matched case‐control study was designed for further exploration. Cases were patients with scleroderma and digital gangrene, while con...
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Full Length Source Type: research
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