Twelve weeks of ombitasvir/paritaprevir/r and dasabuvir without ribavirin is effective and safe in the treatment of patients with HCV genotype 1b infection and compensated cirrhosis: results from a real-world cohort study.

CONCLUSIONS: The simplified regimen of OBV/PTV/r+DSV administered for 12 weeks is effective and safe in patients with chronic HCV genotype 1b infection and compensated cirrhosis. No adverse reactions related to drug-drug interactions were recorded. PMID: 29325476 [PubMed - as supplied by publisher]
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

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Authors: Hrabovsky V, Blaha V, Hyspler R, Ticha A, Skrobankova M, Svagera Z Abstract BACKGROUND: Cholesterol is derived via de novo synthesis and dietary absorption. Both processes can be monitored by determination of non-cholesterol sterol concentrations (lathosterol for synthesis; sitosterol and campesterol for absorption). The hypocholesterolemia that occurs during acute illness is a result of a multifactorial inability to compensate for the increased needs for this metabolite. The aim of this study was to examine the plasma cholesterol profile and both processes of cholesterol acquisition during acute upper gas...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
This study examined the outcomes of umbilical hernia repair in patients with advanced liver disease and compared this with a control group of non-cirrhotic patients.MethodsProspective data were collected regarding the outcome of umbilical hernia repairs performed between 2004 and 2013 at the Austin Hospital, Melbourne, Australia. Outcomes at 90  days were compared between patients with and without cirrhosis.Results79 patients with cirrhosis and 249 controls were analysed. Of the patients with cirrhosis, 9% were classified as Child –Pugh A, 61% were Child–Pugh B and 30% were Child–Pugh C. Emergency re...
Source: Hernia - Category: Sports Medicine Source Type: research
Publication date: Available online 21 September 2018Source: Medical Mycology Case ReportsAuthor(s): Taher Sabobeh, Kamran Mushtaq, Ahmed Elsotouhy, Adham A. Ammar, Sameera RashidAbstractImmunocompromised status is associated with invasive fungal infections including mucormycosis. These infections are challenging to treat and associated with high overall mortality.Here we report a fatal case of invasive mucormycosis in a cirrhotic, diabetic patient. Despite the swift diagnosis and management; the fungal invasion of the right internal carotid artery lead to massive ischemic stroke.Timely diagnosis and management is crucial f...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
ConclusionsThe extent of resection did not significantly affect overall and disease-free survival while tumor characteristics and underlying liver function appeared significant determinants.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusion: The simulations explain how vascular changes due to cirrhosis severely disrupt both hepatic and global hemodynamics. Significance: This study is a priori the first to model the rat's entire blood circulation during cirrhogenesis. Since it is able to simulate cirrhosis main characteristics, the model may be translated to humans for the assessment of liver- interventions.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
To determine whether acoustic radiation force imaging (ARFI) of the liver/spleen could be used in patients with cirrhosis to predict the presence of gastroesophageal varices (GOVs).
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
CONCLUSIONS: Cranioplasty is associated with a high incidence of postoperative seizures. The prophylactic use of AEDs can reduce the occurrence of early seizures. PMID: 30239312 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Hepatitis B virus (HBV) infection is a major global health problem and may cause acute, fulminant, chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma (HCC).1,2 In May 2016, the World Health Assembly adopted the first Global Health Sector Strategy on Viral Hepatitis, 2016-2021. The strategy has a vision of eliminating viral hepatitis as a public health problem. The global targets are set to reduce new viral hepatitis infections by 90% and reduce deaths attributable to viral hepatitis by 65% by 2030 (http://www.who.int/mediacentre/factsheets/fs204/en/).
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Medical progress Source Type: research
In this study, we demonstrate that loss of prolyl-hydroxylase 1 (PHD1-/-) attenuates the development of liver fibrosis in mice subjected to chronic bile duct injury, induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
Young Americans are dying in rising numbers because of drugs, alcohol and suicide, according to new federal data. The Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS) issued its annual comprehensive health and mortality report, which analyzes trends in death rates by cause and demographic. Drugs, alcohol and suicide, the report says, have contributed to the first drops in U.S. life expectancy since 1993. While U.S. life expectancy rose from 77.8 to 78.6 years between 2006 and 2016, the trend reversed during the end of the decade, leading to a 0.3-year decline between 2014 and ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
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