Enhanced chondrogenesis of mesenchymal stem cells over silk fibroin/chitosan ‐chondroitin sulfate three dimensional scaffold in dynamic culture condition

This study successfully demonstrates the potentiality of SF/CS‐Ch scaffold for hMSCs recruitment and redirecting cartilage tissue regeneration with enhanced chondrogenesis. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: Original Research Report Source Type: research

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Some 31 studies by Dr. Piero Anversa contain fabricated or falsified data, officials concluded. Dr. Anversa popularized the idea of stem cell treatment for damaged hearts.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Anversa, Piero Falsification of Data Harvard Medical School Brigham and Women's Hospital Research Heart Stem Cells Clinical Trials Academic and Scientific Journals Source Type: news
Authors: Bahmad HF, Mouhieddine TH, Chalhoub RM, Assi S, Araji T, Chamaa F, Itani MM, Nokkari A, Kobeissy F, Daoud G, Abou-Kheir W Abstract Nervous system tumors represent some of the highly aggressive cancers in both children and adults, particularly neuroblastoma and glioblastoma. Many studies focused on the pathogenic role of the Akt pathway and the mechanistic target of Rapamycin (mTOR) complex in mediating the progression of various types of cancer, which designates the Akt/mTOR signaling pathway as a master regulator for cancer. Current studies are also elucidating the mechanisms of cancer stem cells (CSCs) i...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: The "Clo-Baltimore regimen" is safe and feasible and provides good survivals for patients with myeloid malignancies and haplo-donors. Methods: Here, we report a variant of the Baltimore regimen, where 1) fludarabine was replaced by clofarabine, 2) bone marrow was replaced by peripheral blood stem cells, and 3) tacrolimus was replaced by cyclosporine, in a "Clo-Baltimore regimen". PMID: 30323896 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Gavin-Plagne L, Commin L, Bruyère P, Buff S, Joly T Abstract Animal-derived products are widely used in sperm cryopreservation for their cryoprotective properties. These components, however, tend to be replaced because of sanitary risks. STEMALPHA.CRYO3 (Ref. 5617; Stem Alpha, Saint-Genis-l'Argentière, France), called "CRYO3," is a chemically defined preservation medium currently used for freezing human tissue and adult stem cells. The aim of this study was to evaluate the effect of a CRYO3-based medium on ram sperm freezing regarding in vitro parameters and in vivo fertility. Semen...
Source: Biopreservation and Biobanking - Category: Biomedical Science Tags: Biopreserv Biobank Source Type: research
Publication date: Available online 20 September 2018Source: Best Practice &Research Clinical HaematologyAuthor(s): Mark R. LitzowAbstractBefore the advent of tyrosine kinase inhibitors (TKIs), Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) was associated with dismal survival without allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recent evidence has demonstrated that the combination of TKI and chemotherapy can result in a high rate of complete remission, thereby enabling more patients to proceed to allo-HSCT. However, with more studies reporting non-inferior outcomes with TKI an...
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Yuankun Dai, Kai Jin, Xue Feng, Juan Ye, Changyou GaoAbstractThe ability of repair and regeneration of tissues or organs has been significantly improved by using biomaterials-based constructs. Our previous studies found the regeneration of both articular cartilage and subchondral bone by implantation of a poly(lactide-co-glycolide) (PLGA)/fibrin gel/bone marrow stem cells (BMSCs)/(lipofectamine/pDNA-transforming growth factor (TGF)-β1) construct in vivo, without the step of pre-induced differentiation of the laden stem ce...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 16 October 2018Source: Cell Reports, Volume 25, Issue 3Author(s): Chengkang Zhang, Hyung Joo Lee, Anura Shrivastava, Ruipeng Wang, Travis J. McQuiston, Sharon S. Challberg, Brian A. Pollok, Ting WangSummaryDespite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest. Here, we describe the EpiX method, which utilizes small molecules that inhibit PAK1-ROCK-Myosin II and TGF-β signaling to achieve over one trillion-fold expansion of human epit...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 16 October 2018Source: Cell Reports, Volume 25, Issue 3Author(s): Simon Joost, Tina Jacob, Xiaoyan Sun, Karl Annusver, Gioele La Manno, Inderpreet Sur, Maria KasperSummaryEpithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair follicle bulge and interfollicular epidermis (IFE), respectively, and monitored their individual transcriptional adaptati...
Source: Cell Reports - Category: Cytology Source Type: research
Condition:   Acute Myeloid Leukemia (AML) Interventions:   Drug: Pevonedistat;   Procedure: transplant;   Drug: Azacitidine Sponsors:   Milton S. Hershey Medical Center;   Millennium Pharmaceuticals, Inc.;   Takeda Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study examined the effects of exposure to low-dose nicotine at sub-toxic concentrations on the proliferation, differentiation and migration of bone marrow stem cells (BMSCs) in vitro and their homing to fracture site in C57BL/6 mice. BMSCs were investigated in cells treated with or without nicotine (1 μM to 1 mM). Different concentrations of nicotine exhibited varied effects on BMSCs growth regulation and bone differentiation. CCK8 test significantly increased at a high nicotine concentration of 1 mM while calcium nodule staining with Alizarin red decreased at the same concentration. In vitro scratch test, Transwel...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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