Noninvasive optical spectroscopy for identification of non ‐melanoma skin cancer: Pilot study

ConclusionThis pilot trial utilizes optical spectroscopy as a noninvasive method for determining cutaneous lesion histology. Effect sizes observed across optical parameters for benign and malignant tissue types will guide larger prospective studies that may ultimately lead to prediction of lesional histology without need for invasive biopsy. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - Category: Laser Surgery Authors: Tags: Preclinical Reports Source Type: research

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CONCLUSIONS: The utility of exfoliative cytology for the primary diagnosis of skin cancer is unknown, as all included studies focused on the use of this technique for confirming strongly suspected clinical diagnoses. For the confirmation of BCC in lesions with a high clinical suspicion, there is evidence of high sensitivity and specificity. Since decisions to treat low-risk BCCs are unlikely in practice to require diagnostic confirmation given that clinical suspicion is already high, exfoliative cytology might be most useful for cases of BCC where the treatments being contemplated require a tissue diagnosis (e.g. radiother...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: There is insufficient evidence for the use of RCM for the diagnosis of BCC or cSCC in either population group. A possible role for RCM in clinical practice is as a tool to avoid diagnostic biopsies in lesions with a relatively high clinical suspicion of BCC. The potential for, and consequences of, misclassification of other skin cancers such as melanoma as BCCs requires further research. Importantly, data are lacking that compare RCM to standard clinical practice (with or without dermoscopy). PMID: 30521687 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
dam V Abstract Looking insight pathological processes, metallothioneins (MTs) are considered to be potential biomarkers for monitoring of a development of various types of malignant disease, such as cancer. The early identification of the MT biomarkers in biological tissues could be important tool for the estimation of appropriate clinical therapy. Therefore here we investigated the application of matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) together with immunohistochemical analyses (IHC) using MT-1/2 antibody for MT detection in formalin-fixed paraffin-embedded (FFPE) biopsy ...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
In conclusion, dermoscopy is valuable for the diagnosis of CNH as a first screening tool because of a consistent global dermoscopic configuration (daisy pattern), consisting of radially arranged white thick lines surroun ding a central rounded yellow/brown clod.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Background: Incidence of nonmelanoma skin cancer (NMSC), specifically, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), has been increasing for decades. This increase is multifactorial: better skin cancer detection, increased sun exposure, and increased life expectancy. In addition, biopsy rates (number of biopsies/number of patient visits) are increasing in the U.S. Utah has one of the highest rates of both NMSCs and melanoma in the U.S. Historic figures for BCC:SCC ratio in the U.S.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
ConclusionCaveolin-1 downregulation may increase the susceptibility to both benign and malignant hyperproliferative skin disorders. It could be useful as predictive biomarker of disease severity and progression.
Source: Dermatologica Sinica - Category: Dermatology Source Type: research
In conclusion, dermoscopy is valuable for the diagnosis of CNH as a first screening tool because of a consistent global dermoscopic configuration (daisy pattern), consisting of radially arranged white thick lines surroun ding a central rounded yellow/brown clod.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
AbstractPurpose of ReviewActinic keratosis (AK) is the most common sun-induced preneoplastic lesion, and together with photo-aging and skin cancer, it places a huge burden on healthcare systems. The clinical distinction between AK and incipient squamous cell carcinoma (SCC) can be difficult, and therefore, clinical diagnosis is not always reliable and certain. Skin biopsies are sometimes mandatory, and physicians must be aware of the importance of accurate diagnosis and management, as other malignant neoplasms (melanoma, basal cell carcinoma) cannot always be reliably distinguished from AK, especially when pigmented and in...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
AbstractPurpose of ReviewSkin cancers, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are the most common cancer worldwide. The treatment of these cancers is primarily surgical, and when treated early and correctly, the prognosis is excellent. In this review, we aim to discuss the appropriate surgical management of skin cancers and associated controversies as it pertains to the head and neck.Recent FindingsEvidences guiding treatment have expanded enormously over the past decade. Studies have drastically improved our understanding of skin cancer including risk factors for tumor r...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
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