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Noninvasive optical spectroscopy for identification of non ‐melanoma skin cancer: Pilot study

ConclusionThis pilot trial utilizes optical spectroscopy as a noninvasive method for determining cutaneous lesion histology. Effect sizes observed across optical parameters for benign and malignant tissue types will guide larger prospective studies that may ultimately lead to prediction of lesional histology without need for invasive biopsy. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - Category: Laser Surgery Authors: Tags: Preclinical Reports Source Type: research

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Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
CONCLUSIONS:Biopsies are warranted for any VLU with documented stalled healing following 3 months of standard of care. One biopsy is performed at the periphery of the ulcer and another at the base in order to rule out the presence of malignant transformation because of BCC, squamous cell carcinoma, sarcoma, melanoma, lymphoma, or metastases. BACKGROUND: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies. OBJECTIVE: To report ...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: Features: Case Series Source Type: research
ConclusionOur results could prove useful in discriminating between non‐melanoma skin cancer lesions and healthy skin and in making a specific diagnosis. It is suggested that collecting different quantitative measurements increases the utility of D–OCT and makes the method less observer‐dependent.
Source: Skin Research and Technology - Category: Dermatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The clinical differential diagnosis between malignant and benign skin lesions is sometimes difficult, and dermoscopy may help the clinician to identify which lesion requires skin biopsy or surgical excision. The dermoscopic evaluation of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) often shows pathognomonic features but sometimes is not easy to identify if precancerous actinic keratosis evolved to squamous cell carcinoma without histologic examination. Clinical and dermoscopic differential diagnosis between atypical nevi and in situ superficial spreading melanoma is a big challenge.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
ConclusionThe use of VivaScope 1500 following dermoscopy may improve patient care and management of suspicious skin lesions, although the generalizability of these results to the UK population remains unclear.
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Results suggest that reported skin cancer patterns are changing. There is a need for further research and equitable appropriation of financial resources and effort towards developing primary skin cancer prevention initiatives in SA. PMID: 28112098 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Publication date: October 2016 Source:Pathology - Research and Practice, Volume 212, Issue 10 Author(s): Hamideh Kadeh, Shirin Saravani, Fatemeh Heydari, Saeed Shahraki Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) are two common skin malignancies with different potentials for invasion and metastasis. The mechanism responsible for various growth patterns observed in SCC and BCC is still not fully understood. The aim of this study was to investigate the expression of matrix metalloproteinase-10 in non-melanoma skin cancers, including BCC and SCC of the head and neck. The study group consisted of 60 specimens...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
We reported the case of a 77 year old male patient with retroauricular tumor, which started growing 3 years ago and was excised, buth relapsed three times. The initial diagnosis was infundibular cyst. Dela yed Mohs surgery was performed, as was an additional open lymph node biopsy of the patient’s right groin, on the occasion of an indolent swelling of the same which developed within 3 months. The first histopathological report confirmed the diagnosis of a cystic squamous cell carcinoma. The histo pathologic evaluation of the groin tumor revealed a small lymphocytic B cell lymphoma (BCL). The...
Source: Wiener Medizinische Wochenschrift - Category: Journals (General) Source Type: research
Conclusion: Cutaneous squamous cell carcinoma is uncommon in Indian patients and a high index of suspicion is necessary when a rapidly enlarging nodule, verrucous fungating plaque or an ulcer with everted margins develops in long standing scars and other predisposing dermatologic conditions. Histopathological examination is mandatory to confirm the diagnosis and identify the subtype and this has prognostic implications.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
Abstract The results of skin biopsies over a 10 year period were reviewed from the outpatient dermatology clinic at the Brody School of Medicine in Greenville, North Carolina. This research was conducted because there are very few studies that characterize this information over a long-term horizon. The biopsy rate per patient encounter, the clinical reason for the biopsy, the biopsy outcomes, the distribution of cutaneous malignancies per encounter, and the distribution of the subtypes of basal cell carcinoma, squamous cell carcinoma, and melanoma were analyzed. Biopsy logs from January 1, 2001 to December 31, 201...
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research
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