Noninvasive optical spectroscopy for identification of non ‐melanoma skin cancer: Pilot study

ConclusionThis pilot trial utilizes optical spectroscopy as a noninvasive method for determining cutaneous lesion histology. Effect sizes observed across optical parameters for benign and malignant tissue types will guide larger prospective studies that may ultimately lead to prediction of lesional histology without need for invasive biopsy. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - Category: Laser Surgery Authors: Tags: Preclinical Reports Source Type: research

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ConclusionCaveolin-1 downregulation may increase the susceptibility to both benign and malignant hyperproliferative skin disorders. It could be useful as predictive biomarker of disease severity and progression.
Source: Dermatologica Sinica - Category: Dermatology Source Type: research
In conclusion, dermoscopy is valuable for the diagnosis of CNH as a first screening tool because of a consistent global dermoscopic configuration (daisy pattern), consisting of radially arranged white thick lines surroun ding a central rounded yellow/brown clod.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
AbstractPurpose of ReviewActinic keratosis (AK) is the most common sun-induced preneoplastic lesion, and together with photo-aging and skin cancer, it places a huge burden on healthcare systems. The clinical distinction between AK and incipient squamous cell carcinoma (SCC) can be difficult, and therefore, clinical diagnosis is not always reliable and certain. Skin biopsies are sometimes mandatory, and physicians must be aware of the importance of accurate diagnosis and management, as other malignant neoplasms (melanoma, basal cell carcinoma) cannot always be reliably distinguished from AK, especially when pigmented and in...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
AbstractPurpose of ReviewSkin cancers, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are the most common cancer worldwide. The treatment of these cancers is primarily surgical, and when treated early and correctly, the prognosis is excellent. In this review, we aim to discuss the appropriate surgical management of skin cancers and associated controversies as it pertains to the head and neck.Recent FindingsEvidences guiding treatment have expanded enormously over the past decade. Studies have drastically improved our understanding of skin cancer including risk factors for tumor r...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
CONCLUSIONS:Biopsies are warranted for any VLU with documented stalled healing following 3 months of standard of care. One biopsy is performed at the periphery of the ulcer and another at the base in order to rule out the presence of malignant transformation because of BCC, squamous cell carcinoma, sarcoma, melanoma, lymphoma, or metastases. BACKGROUND: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies. OBJECTIVE: To report ...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: Features: Case Series Source Type: research
ConclusionOur results could prove useful in discriminating between non‐melanoma skin cancer lesions and healthy skin and in making a specific diagnosis. It is suggested that collecting different quantitative measurements increases the utility of D–OCT and makes the method less observer‐dependent.
Source: Skin Research and Technology - Category: Dermatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The clinical differential diagnosis between malignant and benign skin lesions is sometimes difficult, and dermoscopy may help the clinician to identify which lesion requires skin biopsy or surgical excision. The dermoscopic evaluation of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) often shows pathognomonic features but sometimes is not easy to identify if precancerous actinic keratosis evolved to squamous cell carcinoma without histologic examination. Clinical and dermoscopic differential diagnosis between atypical nevi and in situ superficial spreading melanoma is a big challenge.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
ConclusionThe use of VivaScope 1500 following dermoscopy may improve patient care and management of suspicious skin lesions, although the generalizability of these results to the UK population remains unclear.
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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