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MiRNA –mRNA crosstalk in laryngeal squamous cell carcinoma based on the TCGA database

ConclusionsOur study provides the most comprehensive information on the expression of miRNAs in LSCC and identifies the known oncogenic miRNAs (such as miR-163a), as well as aberrant expression of novel miRNAs involved in cell regulation and metabolic defects that occur during development of LSCC.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research

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Conclusion Réunion Island features some particularities in terms of incidence: women are less than half as likely as in Metropolitan France to develop any type of cancer, whereas incidence in males is among highest in France. The presentation of results in cancer registries could be improved in line with everyday practice in head and neck surgery.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
ConclusionsThe vascular ring at the cervicothoracic junction in a patient with RAA made it difficult to dissect the RLN lymph nodes during oncologic esophagectomy. The cervicothoracoscopic approach enables the complete dissection of these lymph nodes and is a useful esophagectomy technique for patients with RAA.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Laryngo-Rhino-Otol 2018; 97: 231-232 DOI: 10.1055/s-0044-100272Ko HC et al. Survival Outcomes for Patients With T3N0M0 Squamous Cell Carcinoma of the Glottic Larynx. JAMA Otolaryngol Head Neck Surg 2017; 143: 1126–1133 Wie ist das Überleben von Patienten mit Kehlkopfkrebs im Stadium T3N0M0, die operativ oder mittels Radiotherapie behandelt wurden? Zur Klärung dieser Frage verglichen chinesische Wissenschaftler die retrospektiven Daten dieser Patienten über einen langfristigen Nachbeobachtungszeitraum. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals...
Source: Laryngo- Rhino- Otologie - Category: ENT & OMF Authors: Tags: Referiert und Diskutiert Source Type: research
Journal of Cellular Biochemistry, EarlyView.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research
Molecular Carcinogenesis, EarlyView.
Source: Molecular Carcinogenesis - Category: Molecular Biology Authors: Source Type: research
Most primary tracheal tumors are malignant. Malignancy of larynx and bronchi are much more likely than trachea. Tracheal tumors are most likely due to direct extension for surrounding tumors. Squamous cell carcinoma and adenoid cystic carcinoma make up about two-thirds of adult primary tracheal tumors. Because of their predominantly local growth pattern, malignant salivary gland –type tumors show a better outcome than other histologic types.
Source: Thoracic Surgery Clinics - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
In Reply We thank Drs D ’Ascanio and Piazza for their comments regarding our study demonstrating similar overall survival outcomes for patients with T3N0M0 glottic carcinoma treated with surgery or radiotherapy. We fully agree that individual patients in the T3 category may exhibit distinct pathophysiologies, be more app ropriately treated by particular therapy approaches, and demonstrate dissimilar clinical outcomes. Such staging granularity, however, does not exist in the National Cancer Database. The primary intent of our study was to evaluate whether overall survival for all T3N0M0-staged patients treated with p ...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
We report the occurrence of microinvasive SCC in a long-standing erythematous lesion of glans penis in a patient, with extensive metastasis. We emphasize the need for awareness among patients and urologists about the premalignant lesions of penis and prompt treatment of such lesions to prevent possible spread of the disease.
Source: Indian Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionOur retrospective analysis of 32 patients with T4a SCCL showed that successful organ preservation surgery is safe and reliable, and associated with a relatively acceptable disease-free survival, normal swallowing function, and acceptable voice quality. More patients with T4a SCCL who wish to preserve the larynx should be considered for organ preservation surgery.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Authors: Qiao B, Luo W, Liu Y, Wang J, Liu C, Liu Z, Chen S, Gu J, Qi X, Wu T Abstract Background &Aims: Quite a few studies had investigated the correlation between CXC chemokine receptor 2 (CXCR2) and cancer. This meta-analysis was aimed to comprehensively summarize the previous studies and to explore the prognostic value of CXCR2 in patients with cancer. Materials and Methods: An adequate literature search in EMBASE and PubMed was conducted. Articles in English which have reported CXCR2 expression in patients and enough data to calculate hazard ratio (HR) were included. Effect estimates were analyzed wit...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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