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MiRNA –mRNA crosstalk in laryngeal squamous cell carcinoma based on the TCGA database

ConclusionsOur study provides the most comprehensive information on the expression of miRNAs in LSCC and identifies the known oncogenic miRNAs (such as miR-163a), as well as aberrant expression of novel miRNAs involved in cell regulation and metabolic defects that occur during development of LSCC.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research

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Authors: Ma L, Xiang J, Zhang Y, Hu H, Shao R, Lin D Abstract PURPOSE: The recurrent laryngeal nerve lymph nodes (RLN LNs) are among the most common metastatic sites in esophageal cancer, and the dissection of these lymph nodes (LNs) is considered beneficial. The purpose of this study was to evaluate the characteristics of RLN LN metastases from esophageal squamous cell carcinoma, and the effects of these metastases on the prognosis of patients. In addition, we aimed to determine the reasonable range of dissection of regional LNs. METHODS: The clinical data from 348 patients who underwent resection for esophage...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
In conclusion, the findings suggested that ER stress‑associated apoptosis is a major mechanism underlying the apoptotic effect of cisplatin and cetuximab on LSCC cells; cetuximab enhanced cisplatin‑induced ER stress‑associated apoptosis in LSCC cells largely by inhibiting the expression of TXNDC5 and thereby increasing ROS production; cisplatin and cetuximab had stimulatory and inhibitory effects on the TXNDC5 gene promoter, respectively. The present study offered novel insights into the pharmacological effects of cisplatin and cetuximab on LSCC. It also suggested that TXNDC5 may be a potential therapeutic target for...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ConclusionsCompared with VATE, RATE resulted in a higher lymph node yield along the left RLN without increasing morbidity.
Source: World Journal of Surgery - Category: Surgery Source Type: research
Authors: Timirci-Kahraman Ö, Verim A, Farooqi AA, Turan S, Özkan-Küçük NE, Yaylim İ Abstract Laryngeal squamous cell carcinoma (LSCC) is a genomically complex disease that is difficult to target, and efforts have been made to identify new treatment strategies and   molecular markers that might stratify patients and individualize options for treatment. miR-373 has diametrically opposed roles in different stages and types of cancers. miR-373 has been suggested to quantitatively control E-cadherin and CD44 expression. We studied the expression of miR-373, E-cadherin and CD44 in la...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
BACKGROUNDTime to treatment initiation (TTI) is increasing and is associated with worsening survival. In the current study, the authors sought to identify a mechanism for this relationship by assessing the effect of TTI on clinical‐to‐pathologic upstaging in patients with head and neck squamous cell carcinoma (HNSCC). METHODSUsing the National Cancer Data Base, the authors analyzed patients receiving definitive surgery for SCC of the oral cavity, oropharynx, larynx, and hypopharynx from 2005 through 2014. The primary outcome was T, N, or stage group upstaging, defined as higher pathologic stage than clinical stage. TTI...
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
Condition:   Advanced Squamous Cell Carcinoma Interventions:   Radiation: Radiation Therapy;   Other: Chemotherapy Sponsor:   University of Florida Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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