Lovastatin promotes myelin formation in NPC1 mutant oligodendrocytes

In this study, by comparing protein expression in the cortical white matter tracts from mice at different postnatal days, we identified that in the NPC1 mutant (NPC1 −/−) mice, the onset of myelination is delayed and the amount of the major myelin protein MBP and PLP, and oligodendrocyte regulatory factor Olig1 and Olig2, but not NG2 and Sox10, decreased significantly, suggesting a disruption of oligodendrocyte differentiation.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research