Investigation of cancer associated fibroblasts and p62 expression in oral cancer before and after chemotherapy
The aim of this study is to investigate the expression of the autophagy protein p62 in oral squamous cell carcinoma (OSCC) cells before and after chemotherapy. We also detected cancer-associated fibroblasts (CAFs) in these OSCC samples to explore the roles of p62 and CAFs in chemotherapy.
Publication date: Available online 31 January 2018 Source:Seminars in Cancer Biology Author(s): Benjamin Solomon, Richard J. Young, Danny Rischin Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. While many HNSCCs are related to classical etiologic factors of smoking and alcohol, a clinically, genomically, and immunologically distinct subgroup of tumors arise from the epithelium of the tonsil and the base of tongue as a result of infection with Human Papilloma Virus (HPV). In this review we...
CONCLUSION: Lymphovascular invasion (LVI) and non-T4 muscular invasion (non-T4MI) significantly increased the locoregional recurrence rate in early stage buccal SCC with clear surgical margins and negative nodal status. Adjuvant treatment with either radiation or chemoradiation should be considered when one or both of these factors present. PMID: 29551166 [PubMed - as supplied by publisher]
Despite significant advancements made in cancer diagnostic and treatment strategies, oral cavity squamous cell carcinoma (OCSCC) continues to have one of the highest rates of mortality among head and neck cancer sites even after trimodality care (surgery, radiation, and chemotherapy). In this retrospective study, we aim to identify factors that predict outcomes and to provide prognostic information to better assist clinicians in making treatment-related decisions
Over 300,000 patients develop squamous cell carcinoma of the oral cavity (OCSCC) worldwide and nearly half of these patients die from the disease each year. Treatment of OCSCC often requires complex, multimodality therapy, employing surgical resection followed by post-operative radiation, with the addition of cisplatin-based chemotherapy for patients with high-risk of failure. Despite these comprehensive treatment strategies, OCSCC recurs in 25% to 48% of patients. Given this poor prognosis, it is evident new strategies are needed to treat OCSCC.
ConclusionThe results of our multicenter retrospective study, which was the largest of its kind to date, suggest that first-line cetuximab plus platinum-based chemotherapy is suitable and well-tolerated for the systemic therapy of recurrent or metastatic OSCC.
Conclusion These results suggest that chemotherapy may increase CAFs in OSCC. High cytoplasmic p62 expression may serve as a poor prognostic marker for OSCC patients.
In conclusion, modified b iweekly TPEx is of comparable efficacy with conventional TPEx and represents a well-tolerated regimen in R/M SCCHN patients. Further evaluation of this protocol in prospective clinical trials is warranted.
AbstractWe herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases. The patient responded well to the therapy, wit...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, with an estimated 63,030 new diagnosed cases and 13,360 deaths in 2017 . Moreover, recurrent and metastatic cases increase annually and treatment is mostly limited to chemotherapy and radiation therapy. Targeted therapies using epidermal growth factor receptor (EGFR)-blocking monoclonal antibody, either alone or in combination with chemotherapy and/or radiotherapy, were recently introduced. However, treatments have been limited due to unfavorable toxicity and new treatment options are still urgently needed to improve patient outcomes .
CONCLUSION The prognostic factors that affect both survival rates and residual QoL are the surgical approach, the neck stage and the DOI, all of which can be minimized by early diagnosis.