Glutamatergic ventral pallidal neurons modulate activity of the habenula - tegmental circuitry and constrain reward seeking
The ability to appropriately integrate and respond to rewarding and aversive stimuli is essential for survival. The ventral pallidum (VP) plays a critical role in processing both rewarding and aversive stimuli. However, the VP is a heterogeneous structure, and how VP subpopulations integrate into larger reward networks to ultimately modulate these behaviors is not known. We identify a non-canonical population of glutamatergic VP neurons that play a unique role in responding to aversive stimuli and constraining inappropriate reward seeking.
Source: Biological Psychiatry - Category: Psychiatry Authors: Jessica Tooley, Lauren Marconi, Jason Alipio, Bridget Matikainen-Ankney, Polymnia Georgiou, Alexxai V. Kravitz, Meaghan C. Creed Tags: Priority Communication Source Type: research