Escalating Symptoms of Anxiety May Point to Older Patients at Greatest Risk of Alzheimer ’s

Older adults experiencing worsening anxiety may have higher levels of a protein fragment implicated in Alzheimer ’s disease, according to astudy published today inAJP in Advance.Past studies have suggested depression and other neuropsychiatric symptoms may be predictors of Alzheimer ’s progression during its “preclinical” phase—a period marked by the accumulation of brain deposits of fibrillar amyloid and pathological tau in a patient’s brain. In the current study, Nancy J. Donovan, M.D., of Brigham and Women ’s Hospital and colleagues examined the association between brain amyloid beta and depression symptoms over time in cognitively normal, older adults.A total of 270 participants aged 62 to 90 underwent baseline positron emission tomography (PET) scans to measure cortical aggregate amyloid beta and annual depression assessments with the 30-item Geriatric Depression Scale (GDS). The team calculated total GDS scores as well as scores for three GDS item clusters: apathy-anhedonia, dysphoria, and anxiety-concentration. These scores were examined over a span of five years.“Rather than just looking at depression as a total score, we looked at specific symptoms such as anxiety,” Donovan said in apress release. “When compared to other symptoms of depression such as sadness or loss of interest, anxiety symptoms increased over time in those with higher amyloid beta levels in the brain.”“These results sugges...
Source: Psychiatr News - Category: Psychiatry Tags: Alzheimer's disease amyloid beta anxiety depression mild cognitive impairment Nancy Donovan Source Type: research

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The Middle East and North Africa (MENA) face daunting challenges in managing a growing burden of mental illness, often in adverse conditions that can leave their imprint on generations to come.While the burden of mental-health conditions is above the global average in most MENA countries, the human resources, policies, funding and infrastructure to deal with these problems are sorely lacking.According to a recent study led by the Institute for Health Metrics and Evaluation (IHME), mental disorders excluding substance abuse accounted for 4.7% of all disability-adjusted life years (DALYs) in the World Health Organization &rs...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
DISCUSSION: Cognitive complaints have robust associations with QOL. These findings have implications for AD prevention trials and management of clinical populations. PMID: 29944474 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
One of the most important things I learned as an Alzheimer's caregiver was how to use bright light to change my mother's mood and behavior.By Bob DeMarcoAlzheimer's Reading RoomMy mother, Dotty, had a tendency to get in a bad mood around 4:30 PM each day. It was like a form of sundowning. Learn more about that situation by following this link.Twilight Moments in Dementia Patients - Sundowning SyndromeShe might say things like I'm going to bed,or something much worse.What really struck me was the look on her face. It seemed like she wasn't there; or, sometimes like she as very unhappy. I didn't like the look on her face and...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimers Dementia alzheimers reading room bright light bright light alzheimers care of dementia patients how to learning Source Type: blogs
DiscussionCOPD is known to be associated with the development of cognitive deficits, in particular, regarding for executive functions and attention, memory and logical reasoning. In this context, MMSE has a low diagnostic accuracy to underline effective cognitive impairment in AD-COPD. Our study shows a higher frequency of frontal deficits and behavioral disturbances in patients with AD and COPD than patients with AD-only. COPD could complicate the management of AD patients, thus necessitating a closer and multidisciplinary monitoring.
Source: Neurological Sciences - Category: Neurology Source Type: research
Dr. Rita A. Jablonski is one of the most knowledgeable and experienced persons I know when it comes to memory care, dementia and caregivers.I forwarded Rita a question from one of our readers."How Often Should You Visit a Memory Care Patient When They First Go In"?This is an important question, and is often a great source of anxiety for Alzheimer's caregivers.The answer often depends on the actual circumstances at the time.Topic -Memory CareBy Rita A. JablonskiAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading RoomEmail:Hi, Bob.The answer depends on the physical and mental condition of both parties. Som...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer care Alzheimers Dementia care of dementia patients dementia care help alzheimers help dementia memory care nursing home senior care Source Type: blogs
Major depressive disorder in patients aged 70 or older is associated with a poorer prognosis than in younger people Related items fromOnMedica New evidence on benzodiazepine link to Alzheimer ’s Anxiety in midlife linked to risk of later dementia Suicide no more likely in men on 5 α-reductase inhibitors Antidepressants differ in effect on weight gain Doctors debate long-term use of psychiatric drugs
Source: OnMedica Latest News - Category: UK Health Source Type: news
An estimated 5.4 million Americans carry a diagnosis of Alzheimer's disease or related dementias (ADRD), and the prevalence is projected to increase to 13.8 million by mid-century with the aging of our population.1 Symptoms of ADRD including agitation, anxiety, apathy, and depression reduce a person's quality of life and increase caregiver burden. Specifically in assisted living facilities (ALF), persons with ADRD can create increased workload for staff with mood changes manifesting as resisting necessary care, verbal outbursts, attempts to leave the facility, or physical aggression.
Source: Geriatric Nursing - Category: Nursing Authors: Source Type: research
This study set out to examine amechanism that activates the attentional network in the salience region of the brain.The results offer a new way to approach anxiety, depression and agitation in patients with dementia.Learn More -Alzheimer's Care Anger, Frustration, and AgitationActivation of neighboring regions of the brain may also offer opportunities to delay the continued decline caused by the disease.The StudyFor three weeks, the researchers helped participants select meaningful songs and trained the patient and caregiver on how to use a portable media player loaded with the self-selected collection of music.“When...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimer's disease Alzheimer's Patients brain health memory music research science Source Type: blogs
Conclusion: Treatments that influence specific symptoms within the overall NPI have the potential to improve patient outcomes in a cost-effective way. This model is a useful tool for evaluating target product profiles of drugs with effect on NPI symptoms in early stages of development.Dement Geriatr Cogn Disord Extra 2018;8:158 –173
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research
One of the biggest issues we face as Alzheimer's caregivers is learning to understand how a person living with dementia thinks and feels, and why they act the way they do.Early on,many of us conclude that the person living with dementia is being mean to us.The changes that come with dementia can bedistressing to a caregiver.As caregivers we often feelangry, disconcerted and sometimes, we feela sense of heavy burden, hopelessness, and even heartbreak.What is The Difference Between Alzheimer's and DementiaBy Bob DeMarcoAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowAs caregive...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer communication alzheimers care alzheimers caregiving awareness dementia help for caregivers family caregiving help alzheimer's help with dementia help with dementia care Source Type: blogs
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