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Escalating Symptoms of Anxiety May Point to Older Patients at Greatest Risk of Alzheimer ’s

Older adults experiencing worsening anxiety may have higher levels of a protein fragment implicated in Alzheimer ’s disease, according to astudy published today inAJP in Advance.Past studies have suggested depression and other neuropsychiatric symptoms may be predictors of Alzheimer ’s progression during its “preclinical” phase—a period marked by the accumulation of brain deposits of fibrillar amyloid and pathological tau in a patient’s brain. In the current study, Nancy J. Donovan, M.D., of Brigham and Women ’s Hospital and colleagues examined the association between brain amyloid beta and depression symptoms over time in cognitively normal, older adults.A total of 270 participants aged 62 to 90 underwent baseline positron emission tomography (PET) scans to measure cortical aggregate amyloid beta and annual depression assessments with the 30-item Geriatric Depression Scale (GDS). The team calculated total GDS scores as well as scores for three GDS item clusters: apathy-anhedonia, dysphoria, and anxiety-concentration. These scores were examined over a span of five years.“Rather than just looking at depression as a total score, we looked at specific symptoms such as anxiety,” Donovan said in apress release. “When compared to other symptoms of depression such as sadness or loss of interest, anxiety symptoms increased over time in those with higher amyloid beta levels in the brain.”“These results sugges...
Source: Psychiatr News - Category: Psychiatry Tags: Alzheimer's disease amyloid beta anxiety depression mild cognitive impairment Nancy Donovan Source Type: research

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One of the biggest issues we face as Alzheimer's caregivers is learning to understand how a person living with dementia thinks and feels, and why they act the way they do.Early on,many of us conclude that the person living with dementia is being mean to us.The changes that come with dementia can bedistressing to a caregiver.As caregivers we often feelangry, disconcerted and sometimes, we feela sense of heavy burden, hopelessness, and even heartbreak.What is The Difference Between Alzheimer's and DementiaBy Bob DeMarcoAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowAs caregive...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer communication alzheimers care alzheimers caregiving awareness dementia help for caregivers family caregiving help alzheimer's help with dementia help with dementia care Source Type: blogs
I’m a little dumb-founded whenever I run across a prescribing trend that goes against all of the available empirical evidence for common sense use of a medication. Nowhere is this more evident than with the prescription of atypical antipsychotic medications. It wouldn’t be too far a stretch to suggest that such prescriptions have become like Prozac prescriptions in the 1990s, the latest medication fad. But atypical antipsychotics, like Seroquel (quetiapine fumarate), are far more complex with far more problematic side effects than drugs like Prozac, and should only be prescribed for on-label use. The Washingto...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic General Medications Policy and Advocacy Adverse Effects Atypical Antipsychotic Bipolar Disorder Insomnia movement disorder Seroquel side effects Weight Gain Source Type: blogs
According to the Alzheimer’s Association, “Today, someone in the United States develops Alzheimer’s every 65 seconds. By mid-century, someone in the United States will develop the disease every 33 seconds.” To date, there is no cure regarding this most common form of dementia, which affects nearly all individuals worldwide regardless of race, or socioeconomic status, a trend that continues to grow at a disturbingly alarming rate. Scientists however are close to identifying contributing factors that may hinder or help the progression of this illness in the long run. Listed below are the top 5 f...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Memory and Perception Stress Alzheimer's disease Memory Loss Source Type: blogs
Authors: Grundy J, Mouzakis K, Vasa R, Cain A, Curumsing M, Abdelrazek M, Fernando N Abstract By the 2050, it is estimated that the proportion of people over the age of 80 will have risen from 3.9% to 9.1% of population of Organisation for Economic Cooperation and Development countries. A large proportion of these people will need significant help to manage various chronic illnesses, including dementia, heart disease, diabetes, limited physical movement and many others. Current approaches typically focus on acute episodes of illness and are not well designed to provide adequately for daily living care support. In o...
Source: Studies in Health Technology and Informatics - Category: Information Technology Tags: Stud Health Technol Inform Source Type: research
CONCLUSIONS: A comprehensive assessment including psychological and clinical measures should be routinely integrated in clinical practice for the evaluation of patients with early AD. PMID: 29633747 [PubMed - in process]
Source: Acta Bio-Medica : Atenei Parmensis - Category: General Medicine Authors: Tags: Acta Biomed Source Type: research
I had to put my life on hold when I decided to take responsibility for my mother. After 8 years of care giving, I found great emotional reward in caring for her. However, I met other caregivers that were clearly suffering from the experience.byAlzheimer's Reading RoomAstudy of spouses ofdementia patients at Case Western Reserve University found that:Some caregivers may have feelings of guilt about participating in activities with friends or in the community when their loved ones are no longer able to do soCaregivers report feelings ofsadness and loneliness25 percent of caregivers in the study suffered fromdepressionand, on...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer Alzheimer spouses Alzheimer's support group alzheimers disease Dementia Patients loneliness medical science mental health sadness Source Type: blogs
Abstract BACKGROUND: The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD). METHODS: Participants were ⩾60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT). MCI-LB was diagnosed if two or more diagnostic features of dementia with...
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Background/ObjectivesBehavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI). DesignLongitudinal observational cohort study. SettingAcademic medical center. ParticipantsMembers of an apolipoprotein E (APOE) ɛ4 genetically enriched cohort of Ma...
Source: Journal of the American Geriatrics Society - Category: Geriatrics Authors: Tags: Clinical Investigation Source Type: research
The sign comes 10 years before memory and thinking problems are obvious. *** ~ THE EBOOKS ~ Escape from low mood or depression with my "Activate ebook" Discover how to deal with anxiety in my "Anxiety plan ebook" Boost your motivation for anything with my "Spark ebook" by Dr JEREMY DEAN ***
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
The drug protected nerve cell functioning, reduced inflammation and nerve cell loss. *** ~ THE EBOOKS ~ Escape from low mood or depression with my "Activate ebook" Discover how to deal with anxiety in my "Anxiety plan ebook" Boost your motivation for anything with my "Spark ebook" by Dr JEREMY DEAN ***
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
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