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Mesoporous lipid-silica nanohybrids for folate-targeted drug-resistant ovarian cancer

New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7NJ03334F, PaperSayan Samanta, Lina Pradhan, Dhirendra Bahadur Folic acid (FA) targets cancer by exploiting its overexpression of folic acid receptors (FR). A novel folate conjugated lipid coated mesoporous silica nanoparticle has been synthesized in this study to... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research

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Abstract Gastric cancer is the fifth most common malignancy all over the world, and the factors that can affect progress and prognosis of the gastric cancer patients are various, such as TNM stages, invasive depth, and lymph node metastasis ratio. T cell immunity is important component of human immunity system and immunity responding to tumor and dysfunction or imbalance of T cell immunity will lead to serious outcomes for body. T cell immunity includes many different types of cells, CD4+ T cell, CD8+ T cell, memory cell, and so on, and each of them has special function on antitumor response or tumor immune escape...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Objective: The best course of treatment for recurrent ovarian cancer is uncertain. We sought to determine whether secondary cytoreductive surgery for first recurrence of ovarian cancer improves overall survival compared with other treatments. Materials and Methods: We assessed survival using Surveillance, Epidemiology and End Results-Medicare data for advanced stage ovarian cancer cases diagnosed from January 1, 1997 to December 31, 2007 with survival data through 2010 using multinomial propensity weighted finite mixture survival regression models to distinguish true from misclassified recurrences. Of 35,995 women age...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research
Nicole E. James, Clinton Chichester, Jennifer R. Ribeiro
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this video, Dr. Elizabeth Swisher reviews the use of PARP inhibitors in ovarian cancer, and the importance of understanding how resistance to these agents develops.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Conferences/AACR Street Team Breast Cancer News Source Type: news
Condition:   Ovarian Cancer Intervention:   Sponsor:   AstraZeneca Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Experimental Biology 2018) Results from some of the first studies to examine hemp's ability to fight cancer show that it might one day be useful as plant-based treatment for ovarian cancer. Hemp is part of the same cannabis family as marijuana but doesn't have any psychoactive properties or cause addiction.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractExposure to psychosocial stressors and ensuing stress physiology have been associated with spontaneous invasive mammary tumors in the Sprague-Dawley rat model of human breast cancer. Mammary gland (MG) development is a time when physiologic and environmental exposures influence breast cancer risk. However, the effect of psychosocial stress exposure on MG development remains unknown. Here, in the first comprehensive longitudinal study of MG development in nulliparous female rats (from puberty through young adulthood; 8 –25 wks of age), we quantify the spatial gradient of differentiation within the MG of social...
Source: Journal of Mammary Gland Biology and Neoplasia - Category: Cancer & Oncology Source Type: research
Publication date: 1 July 2018 Source:Journal of Organometallic Chemistry, Volume 866 Author(s): Krzysztof Lyczko, Monika Lyczko, Sylwia Meczynska-Wielgosz, Marcin Kruszewski, Józef Mieczkowski A new series of tricarbonyl complexes of rhenium(I) in the ‘2 + 1’ system with the bidentate ligand N-methylpyridine-2-carbothioamide (NC5H4-CS-NH-CH3, LH(Me) NS) and a monodentate ligand, being either an anion (Cl, Br, I or SCN) or a neutral molecule (3,5-dimethylpyrazole (Hdmpz) or imidazole (Him)), was synthesized. The use of mixed ligands leads to the formation of neutral or cationic (in the form of ...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
Authors: Gao Y, Xu Y, Wang J, Yang X, Wen L, Feng J Abstract Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. LncRNA MNX1-AS1has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Here, we found that the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration and invasion of GBM cells. In terms of mechanism, we found that MNX1-AS1 could bind to miR-4443 in GBM cells. Overex...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
Authors: Tai H, Wu Z, Sun S, Zhang Z, Xu C Abstract Fibroblast growth factor receptor-like-1 (FGFRL1) has been identified as the fifth fibroblast growth factor receptor. So far, little is known about its biological functions, particularly in cancer development. Here, for the first time, we demonstrated the roles of FGFRL1 in ovarian carcinoma (OC). An array and existing databases were used to investigate the expression profile of FGFRL1 and the relationship between FGFRL1 expression and clinicopathological parameters. FGFRL1 was significantly upregulated in OC patients, and high FGFRL1 expression was correlated wit...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
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