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Selective Adsorption of Globulin on Nanofiber Meshes for Immunoadsorption Therapy

New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7NJ04672C, PaperRio Kurimoto, Koki Namekawa, Amanda V. Ellis, Masanobu Naito, Mitsuhiro Ebara Immunoadsorption is an effective therapy for patients with autoimmune diseases. Here, we report on a simple and cost effective method to remove immunogloblin selectively using surface-functionalised nanofiber meshes. The surface... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research

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AbstractDiagnosis of latent tuberculosis infection in patients with immune-mediated inflammatory chronic diseases (IMIDs) can be challenged as diagnostic test reliability could be impaired by immunosuppression. We retrospectively analyzed the Quantiferon Gold-Test in-Tube (QFT-G-IT) results of all patients with IMIDs seen at the Department of Internal Medicine of Son Ll àtzer Hospital, Palma de Mallorca (Spain), looking for the factors related to QFT-G-IT indeterminate results. During the study period (2008–2015), 520 patients met the inclusion criteria. Factors associated with indeterminate QFT-G-IT results i...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: Hyperthyroid patients with newly diagnosed GD had global hypomethylation and lower DNMT1 expression in T and B lymphocytes. The results provide the first demonstration that antithyroid drugs or radioiodine treatment restores global DNA methylation and DNMT1 expression with concurrent relief of hyperthyroidism. PMID: 29336230 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Authors: Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT Abstract INTRODUCTION: Traumatic brain injury (TBI) is a major worldwide neurological disorder of epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms of TBI. Encouragingly, there are emerging data showing that biofluid-based TBI biomarker tests have the potential to diagnose the presence of TBI of different severities including concussion, and to predict outcome. Area covered: The authors provide an update on the current knowledge of TBI biomarkers, including protein biomarkers for neuronal cell body ...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
The biotech firm will develop bispecific antibodies to treat autoimmune and inflammatory diseases
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
(Osaka University) Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG). A cure for NMO remains elusive. Osaka University researchers recently established a localized NMO rat model by injecting NMO-IgG into the spinal cord, and assessed the efficacy of anti-repulsive guidance molecule-a (RGMa) antibody in treating NMO. They found anti-RGMa antibody delayed the onset and attenuated the severity of clinical symptoms of NMO, suggesting that humanized anti-RGMa antibody is a potentially valid therapeutic approach for NMO.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Duke-NUS Medical School) A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no cure.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions &InferencesAntineuronal antibodies were significantly more frequent in GI patients and associated with functional effects on bowel secretion. Future studies will determine whether such antibodies indicate patients who might benefit from additional antibody‐directed therapies. However, well‐characterized encephalitis‐related autoantibodies such as against DPPX were not detected, underlining their rarity in routine cohorts. In this study, we examined the frequency and functional effects of antineuronal antibodies in gastrointestinal patients. Antineuronal autoantibodies were significantly more frequent...
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study; thyroid glands of 59 patients with a diagnosis of Hashimoto ’s thyroiditis based on ultrasonographic and biochemical features, and 26 healthy volunteers without autoimmune thyroid disease and thyroid function disorders, were evaluated with shear-wave elastography. Patients with Hashimoto thyroiditis were further subdivided into three categories based on gr ay-scale ultrasonography findings as focal thyroiditis (grade 1), diffuse thyroiditis (grade 2), and fibrotic thyroid gland (grade 3).ResultsPatients with Hashimoto ’s thyroiditis (n = 59) had significantly higher elasticity values (1...
Source: Journal of Medical Ultrasonics - Category: Radiology Source Type: research
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Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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