Selective Adsorption of Globulin on Nanofiber Meshes for Immunoadsorption Therapy
New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7NJ04672C, PaperRio Kurimoto, Koki Namekawa, Amanda V. Ellis, Masanobu Naito, Mitsuhiro Ebara Immunoadsorption is an effective therapy for patients with autoimmune diseases. Here, we report on a simple and cost effective method to remove immunogloblin selectively using surface-functionalised nanofiber meshes. The surface... The content of this RSS Feed (c) The Royal Society of Chemistry
The case of a 51-year-old man with eosinophilic myocarditis was simpler than it seemed.Medscape Rheumatology
Lupus is a chronic, autoimmune multisystem inflammatory disease that is associated with sizable morbidity and mortality.1 When lupus commences in an individual less than 18 years of age,2 it is commonly referred to as childhood-onset systemic lupus erythematosus (cSLE). With a reported incidence of 0.3-0.9 per 100 000 children per year, and a prevalence of 3.3-24 per 100 000 children,3 cSLE is rare. About 10%-20% of all patients with SLE are diagnosed during childhood. Typically, cSLE has a more severe clinical course than that seen in adults, with a higher prevalence of lupus nephritis, hematologic anom ali...
We report the isolation of a novel diterpene, designated as `amethane', from Isodon amethystoides (Lamiaceae). The diterpene [amethinol A; systematic name: (4aR,4bR,7R,10aS)-4b,7-dihydroxy-7-isopropyl-1,1-dimethyl-9-oxododecahydrobenzo[a]azulene-4a(2H)-carboxylic acid], possesses a unique skeleton containing a six/five/seven-membered tricyclic system. Intermolecular O — H...O close contacts were found to the carboxyl, carbonyl and hydroxy groups, connecting molecules into a two-dimensional structure. A possible biosynthetic pathway has been proposed. In addition, the compound was evaluated for its biological activiti...
Publication date: Available online 23 April 2018 Source:Brain, Behavior, and Immunity Author(s): Alexander W. Kusnecov
Conclusions Coverage of fertility preservation is extremely limited in scope of benefits and the number of states that require such benefits. State governments can increase access to a fertility preservation benefit by removing spousal criteria and expanding diagnostic criteria, and by including the benefit in Medicaid plans.
Tumor necrosis factor (TNF) antagonists are the first-line treatment for many autoimmune diseases. However, they have been associated with reactivation of hepatitis B virus (HBV). We determined the rate of HBV reactivation and hepatotoxicity grade 3 or 4 (HT ≥3) in patients treated with an anti-TNF agent for an autoimmune disease.
Researchers found a mechanism that may explain why the Epstein-Barr virus is associated with certain autoimmune illnesses such as lupus.
Early results from a trial investigating the link between antidiabetic drugs and autoimmune diseases may have found an association, researchers have revealed
We describe patients in whom unexplained chronic cough was associated with dry eyes. Focused workup revealed undiagnosed Sjogren’s syndrome in 36%. Dry eyes, with or without SS, is under-recognized and should be added to diagnostic algorithms for unexplained cough.
AbstractThe study aims to analyse the clinical and immunological manifestations of paediatric antiphospholipid syndrome (APS) in patients, based on the 2006 revised classification criteria of definite APS. Fifty-eight paediatric patients with APS were enrolled and analysed retrospectively. A total of 37 female and 21 male patients with a mean age of 14 ± 3 years at disease onset were included. Fourteen (24%) cases were primary APS, and 40 (69%) cases were secondary to systemic lupus erythaematosus (SLE). Anti-nuclear antibody (ANA) positivity and hypocomplementemia were more common in secondary APS t...