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Clinical management of a unique case of PNET of the uterus during pregnancy, and review of the literature

AbstractRationale:PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood.Patient concerns:In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation.Diagnoses:During the 25th week of pregnancy, the patient was referred to our hospital at night with severe anemia and suspected hemoperitoneum. She underwent an emergency caesarean section, delivering a female fetus weighing 400 g, with an Apgar score of 7 at 1 minute and 9 at 5 minutes.Intervention:During surgery, we found a huge uterine sarcoma-like metastatic tumor, invading the pelvic peritoneum and parametria bilaterally; the adnexae seemed disease-free. We performed a type B radical hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, omentectomy, appendectomy, and excision of a bulky lymph node. Seven days after delivery, staging computed tomography (CT) scan demonstrated a large lombo-aortic lymph node compressing the left renal vein and we completed debulking with a second surgery, including diaphragmatic peritonectomy and excision of a huge lymph node by lombo-aortic lymphadenectomy, requiring partial reconstruction of an infiltrated renal vein.Outcome:Ten...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

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Authors: Roelofs K, Shaikh F, Astle W, Gallie BL, Soliman SE Abstract A child with bilateral familial retinoblastoma underwent staging MRI brain and orbit which identified subtle leptomeningeal enhancement, thus prompting an MRI whole body, which revealed a retroperitoneal mass, confirmed on laparoscopic biopsy to be neuroblastoma. This is the first reported case of these two rare embryonal non-central nervous system tumors occurring concurrently. The cause of this concurrence is unknown despite their pathogenic similarities with a chance of 4 cases per 10 billion children aged 1-4 years. Incidental neuroblast...
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Authors: Yang L, Zhao S, Xia P, Zheng HC Abstract REIC (Reduced Expression in Immortalized Cells) gene is down-regulated in immortalized cells, compared with the normal parental counterparts. Its encoding protein could inhibit colony formation, tumor growth, and induce apoptosis. To investigate the roles of REIC expression in lung cancer, we examined REIC expression in lung cancer cells and tissues by RT-PCR or Western blot, and observed the effects of both recombinant REIC exposure and REIC overexpression on the aggressive phenotypes of lung cancer cells. It was found that the demethylation of REIC promoter by 5-A...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
The teenage pregnancy prevention framework and the framework for supporting teenage mothers and young fathers are designed to help local areas assess their local programmes to see what's working well, identify any gaps in services and strengthen the prevention and support pathways for all young people, young parents and their children. Both frameworks provide an evidence-based structure for a collaborative whole system approach to prevent teenage pregnancies and support teenage parents.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Series Type : Expression profiling by arrayOrganism : Ovis ariesThe Alpha Adrenergic Signaling Pathway is one of the chief regulators of cerebrovascular tone and cerebral blood flow (CBF), mediating its effects in the arteries through alpha1-adrenergic receptors (Alpha1AR). In the ovine middle cerebral artery (MCA), with development from a fetus to an adult, others and we have shown that Alpha1AR play a key role in contractile responses, vascular development, remodeling, and angiogenesis. Importantly, Alpha1AR play a significant role in CBF autoregulation, which is incompletely developed in a premature fetus as compared to...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Ovis aries Source Type: research
Authors: Lee MJ, Mok J, Patel P Abstract Recently, minimally invasive spine arthrodesis has gained popularity among spine surgeons. Minimally invasive techniques have advantages and disadvantages compared with traditional open techniques. Comparisons between short-term outcomes of minimally invasive transforaminal interbody fusion and open transforaminal interbody fusion in terms of estimated blood loss, postoperative pain, and hospital length of stay have been well documented and generally favor the minimally invasive technique. However, the advantages of minimally invasive transforaminal interbody fusion must be ...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Authors: Frank RM, Cotter EJ, Strauss EJ, Jazrawi LM, Romeo AA Abstract Management of proximal and distal biceps tendon pathology is evolving. The long head of the biceps tendon, if inflamed, may be a pain-producing structure. In appropriately indicated patients, a symptomatic long head of the biceps tendon can be surgically managed via tenotomy, tenodesis, and/or superior labrum anterior to posterior repair. In some patients, primary superior labrum anterior to posterior pathology can be managed via biceps tenodesis. Determining which procedure is most appropriate and which technique and implant are preferred for ...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
WhatsApp is one of those apps which practically every doctor uses routinely in India. Most doctors use it for personal reasons , and many have also started utilising it to connect with their patients as well. Unfortunately, they do it in a disorganized and haphazard fashion, which means they are not making the best possible use of this very versatile platform !Here's one way of making sure that WhatsApp can be used effectively to help improve medical care.The doctor needs a dedicated mobile just for his clinic, which is used exclusively for this purpose , so he doesn't get troubled at all odd hours because of patients cont...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
While every birth experience is different, some Australian mothers are claiming there is one simple technique that can 'reduce' discomfort and 'mental pain' throughout the process.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
[News24Wire] Suspended Gauteng director of mental health Dr Makgabo Manamela has resigned. Deputy Director General for provincial communication services Thabo Masebe confirmed that Manamela's resignation was received on Wednesday afternoon.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Do patients undergoing robotic-assisted hysterectomy have increased pulmonary complications compared to those undergoing total abdominal hysterectomy?Anesthesia &Analgesia
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
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