ICYMI: Why 2017 medicine approvals matter

This week, the U.S. Food and Drug Administration ’s (FDA) Center for Drug Evaluation and Research (CDER)released its 2017 New Drug Therapy Approvals report. Last year marked an extraordinary milestone for the biopharmaceutical industry and the FDA with major medicine approvals. According to the report, the FDAapproved 46 new molecular entities for a range of disease states -- the highest number of new medications in 21 years.
Source: The Catalyst - Category: Pharmaceuticals Tags: FDA Drug Development Multiple Sclerosis PDUFA New Era of Medicine Source Type: news

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ConclusionDietary intake holds the potential to lower MS-related fatigue, but solid conclusions are not possible based on the existing evidence. Sparse evidence points towards an effect of adequate magnesium and folate intake and a trend for decreased fatigue.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 20 August 2018Source: Neurología (English Edition)Author(s): M. Mendibe Bilbao, S. Boyero Durán, J. Bárcena Llona, A. Rodriguez-AntigüedadAbstractBackgroundThe course of multiple sclerosis (MS) is influenced by sex, pregnancy and hormonal factors.AimsTo analyse the influence of the above factors in order to clarify the aetiopathogenic mechanisms involved in the disease.MethodsWe conducted a comprehensive review of scientific publications in the PubMed database using a keyword search for ‘multiple sclerosis’, ‘MS’, ‘EAE’, &lsquo...
Source: Neurologia - Category: Neurology Source Type: research
Oliver Findling, Heiko Rust, Özgür Yaldizli, Dionne P. H. Timmermans, Alja Scheltinga, John H. J. Allum
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractPurposeGadolinium-based contrast agent (GBCA) effect on automated segmentation algorithms of subcortical gray matter (GM) is not fully known. The aim of this study is to determine gadolinium effect on the segmentation of the thalamus and whole brain tissue using different automated segmentation techniques.MethodsEighty-four multiple sclerosis (MS) patients underwent an MRI acquisition of two 3DT1-weighted sequences with and without gadolinium injection among which 10 were excluded after image quality check. Manual thalamic segmentation considered as gold standard was performed on unenhanced T1 images. volBrain and ...
Source: Neuroradiology - Category: Radiology Source Type: research
Condition:   Multiple Sclerosis Intervention:   Behavioral: Positive Psychology Sponsors:   Brigham and Women's Hospital;   Consortium of Multiple Sclerosis Centers;   Massachusetts General Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Gloria Castellazzi, Laetitia Debernard, Tracy R. Melzer, John C. Dalrymple-Alford, Egidio D'Angelo, David H. Miller, Claudia A. M. Gandini Wheeler-Kingshott, Deborah F. Mason
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with unknown etiology, which typically is manifested in early to middle adulthood. Recently, genome-wide association studies have identified susceptibility of immune-related genes to be involved in MS predisposition. The goal of the current study was to investigate the association of single nucleotide polymorphisms (SNP) with the immunologically related genes responsible for the disease, composed of CD58 (rs2300747 A>G), CD226 (rs763361 C>T), and HLA-G (rs1611715 A>C), with MS susceptibility. In this case ...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Conclusions These findings further confirm the use of circulating serum miRNAs as biomarkers to diagnose and monitor disease status in MS. Classification of evidence This study provides Class III evidence that levels of circulating miRNAs identify patients with MS.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Class III, Multiple sclerosis Article Source Type: research
Publication date: Available online 18 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Lorenzo Razzolini, Emilio Portaccio, Maria Laura Stromillo, Benedetta Goretti, Claudia Niccolai, Luisa Pastò, Isabella Righini, Elio Prestipino, Marco Battaglini, Antonio Giorgio, Nicola De Stefano, Maria Pia AmatoAbstractBackgroundDefinition of benign multiple sclerosis (BMS) remains controversial. Moreover, a sizeable proportion of classically defined BMS patients may be no longer benign (NLB) when re-assessed in the long-term. In a previous work we found that after a five –year follow-up, a clinical s...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Russell DeJong: "The most scholarly neurologist in the Academy". J Hist Neurosci. 2018 Jul-Sep;27(3):245-250 Authors: Reich SG Abstract Russell Nelson DeJong (1907-1990) became professor and chair of the Department of Neurology at the University of Michigan in 1950. A prolific author with more than 200 publications, DeJong wrote on virtually all areas of neurology. DeJong's classic monograph, The Neurologic Examination (1950), grew into an encyclopedic volume from lectures he gave to junior and senior medical students; DeJong saw it through four editions. He was one of the founders of the Ame...
Source: Journal of the History of the Neurosciences - Category: Neuroscience Tags: J Hist Neurosci Source Type: research
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