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Transoral robotic surgery for oropharyngeal carcinoma: Surgical margins and oncologic outcomes

ConclusionThe need to take ≥2 margins to achieve resection portends an increased risk of locoregional recurrence and death due to disease in oropharyngeal SCC.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Purpose of review Oropharyngeal cancer (OPC) incidence is increasing worldwide, especially in developed countries where it seems to be etiologically related to the elevating rates of high-risk human papillomavirus (HPV) infection. Considered a distinct disease because of its weak correlation with the traditional risk factors (tobacco use and alcohol), it has different patterns of survival outcomes, locoregional and distant failure, generally with better prognosis independently of the treatment. The standard therapeutic approach for locally advanced (LA) OPCs includes radiation therapy with concurrent chemotherapy, result...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Gilberto de Castro Junior Source Type: research
The recent epidemic of human papillomavirus (HPV) –related oropharyngeal squamous cell carcinoma (OPSCC) has resulted in the identification of a patient subpopulation with distinct clinical features and outcomes. Viral-related cancers of the head and neck typically have a better prognosis and response to current standard treatment. As both Epstei n-Barr virus (EBV) and HPV are most associated with the lymphoid-rich sites of the head and neck, albeit different sites, we aimed to determine if co-infection of these two viruses plays a role in OPSCC.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
ConclusionsHPV‐related OPSCCs are associated with complete nodal response after 46 Gy of IMRT. Patients with full regional control (pN0) after IMRT and subsequent neck dissection show a significantly better overall survival, but smoking negatively interacts with this effect. Level of Evidence4 Laryngoscope, 2018
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
CONCLUSION: Oropharynx cancer with significant p16 expression showed an increased overall survival and elevated T- and B-lymphocyte infiltration, which suggests a prognostic relevance of immune cell infiltration. PMID: 29493423 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Authors: Wagner S, Böckmann H, Gattenlöhner S, Klussmann JP, Wittekindt C Abstract Based on clinical and experimental data, oropharyngeal squamous cell carcinomas (OPSCC) associated with human papillomavirus (HPV) have been recognized as a distinct entity of head and neck cancers. However, outside of clinical trials, HPV status currently has no impact on treatment. The natural replication cycle of HPV takes place in epithelial cells, and is thus spatially separated from cytotoxic immune cells in the epidermis. Dendritic cells (Langerhans cells, LC), however, are frequent in this upper dermal layer. T...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Abstract BackgroundThe effect of increasing time to definitive radiotherapy (RT) for patients with oropharyngeal squamous cell carcinoma (SCC) is unknown. MethodsNodal tumor volumes at staging and simulation were compared for patients with oropharyngeal SCC. Time from staging to initiation of RT was tabulated. The primary endpoint of interest was nodal progression at simulation. ResultsIncreasing time to simulation was associated with nodal progression in 144 patients (r = 0.474; P
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
Human papillomavirus (HPV) is a sexually transmitted infection that causes most oropharyngeal cancer cases in the United States [1,2]. While there are over 100 types of HPV, only 13 are considered carcinogenic, most notably HPV16 [3]. The proportion of oropharyngeal cancers in the U.S. that are caused by HPV has increased from approximately  20% in 1990 to more than 70%, and the incidence of HPV-related oropharyngeal squamous cell carcinoma (HPV-OPSCC) has increased 225% over the past 20 years [2].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
ConclusionThe TORS‐based approach was associated with superior survival in patients with HPV‐negative oropharyngeal SCC; similar difference was not observed in patients with HPV‐positive disease.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
SUMMARY: The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus–related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(–) oropharyngeal squamous cell car...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: HEAD & amp; NECK Source Type: research
AbstractThe favorable features of high-risk human papillomavirus (HPV) in the head and neck are limited to those harboring transcriptionally-active HPV, which occur predominantly in the oropharynx (OP). Factors rendering the OP susceptible to HPV oncogenesis are largely unexplored. The role of cytokeratin 7 (CK7) in predisposition to HPV and cancer in the cervix has been evaluated. However, its significance in the H&N is unknown. CK7 immunohistochemistry was performed on a tissue microarray cohort of OP and non-oropharyngeal (NOP) squamous cell carcinomas (SCC) with known clinical follow-up and HPV E6/7 mRNA status. Expres...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
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