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Hyperactive brain networks can multiply fibromyalgia pain: Study

A medical study found evidence that fibromyalgia patients have hypersensitive brain networks that multiply pain.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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• Conditioned pain modulation (CPM) facilitation observed in fibromyalgia patients• Smaller periaqueducal gray (PAG) volume observed in fibromyalgia patients• PAG resting connectivity with cortical areas associated with pain inhibition• PAG-to-brainstem connectivity helps explain CPM facilit ation in fibromyalgia• Consistent with pathological pain-facilitative brainstem mechanisms found in animals
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Report Source Type: research
Authors: Pergolizzi JV, Lequang JA, Taylor R, Raffa RB, Colucci D, NEMA Research Group Abstract Cannabinoids appear to possess many potential medical uses, which may extend to pain control. A narrative review of the literature has found a variety of studies testing botanical and synthetic cannabinoids in different pain syndromes (acute pain, cancer pain, chronic noncancer pain, fibromyalgia pain, migraine, neuropathic pain, visceral pain, and others). Results from these studies are mixed; cannabinoids appear to be most effective in controlling neuropathic pain, allodynia, medication-rebound headache, and chronic no...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Purpose: To quantify the morphology of corneal basal epithelium and subbasal nerves and to evaluate the ocular surface alterations in patients with fibromyalgia (FM). Methods: Patients with FM (n = 34) and healthy controls (n = 42) were enrolled. All participants underwent ocular surface tests in the following order: corneal sensitivity, tear film breakup time, lissamine green staining, Schirmer test, and the Ocular Surface Disease Index questionnaire. Basal epithelial cells and subbasal nerves were evaluated using in vivo confocal microscopy (IVCM). Demographic characteristics, Visual Analog Scale for Pain (VAS), Ame...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Discussion: The findings confirm the importance of pain-related activity management patterns as predictors of patient function, and support the necessity of addressing these factors in chronic pain treatment. In addition, the results suggest that targeting increases in activity pacing and decreases in pain avoidance, specifically, might yield the best patient outcomes. However, further research to evaluate this possibility is necessary.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
CONCLUSION: Reduced nociceptive ASIC3, Nav1.7 and Nav1.8 proteins are involved in the preventive effects of EA against FM, and this series of molecules may represent targets for FM treatment. PMID: 29343477 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
The objective of this study was to explore the perceptions of fatigue and sleep dysfunction, and exercise in people with FMS. Three, 60 –90 min focus groups were conducted with people with FMS (n = 14). Participants were recruited from patient support groups who had experienced therapeutic exercise in the management of their condition. Focus groups were video and audio recorded and transcriptions analysed for thematic content by three independent evaluators. Fatigue, sleep dysfunction, and pain were universally reported by participants. The over-arching theme to emerge was a lack of understanding o...
Source: Rheumatology International - Category: Rheumatology Source Type: research
There are few subjects that can stir up stronger emotions among doctors, scientists, researchers, policy makers, and the public than medical marijuana. Is it safe? Should it be legal? Decriminalized? Has its effectiveness been proven? What conditions is it useful for? Is it addictive? How do we keep it out of the hands of teenagers? Is it really the “wonder drug” that people claim it is? Is medical marijuana just a ploy to legalize marijuana in general? These are just a few of the excellent questions around this subject, questions that I am going to studiously avoid so we can focus on two specific areas: why do...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Drugs and Supplements Health Pain Management Source Type: blogs
(Michigan Medicine - University of Michigan) New research reports that hyperreactive brain networks could play a part in the hypersensitivity of fibromyalgia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Discussion: This sodium channelopathy is another entity in the growing number of diseases causing widespread myalgic pain that resembles the pain seen in fibromyalgia syndrome. Muscle Nerve, 2017
Source: Muscle and Nerve - Category: Internal Medicine Authors: Tags: Short Reports Source Type: research
The role of physical and psychological trauma precipitating fibromyalgia is often encountered by physicians, yet a proper systematical review of this association is lacking. Literature searches identified 51 studies which examined the association of fibromyalgia with a preceding traumatic event of physical or emotional nature. The overall quality of evidence of studies included, as assessed by the GRADE criteria, was low, however the majority of studies described a significant association between prior physically traumatic events and the onset of chronic widespread pain or fibromyalgia.
Source: Seminars in Arthritis and Rheumatism - Category: Rheumatology Authors: Source Type: research
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