BRCA Breast Cancer Gene Doesn't Affect Survival

BRCA mutations are inherited and increase the risk of breast and ovarian cancers. Between 45 percent and 90 percent of women with a BRCA mutation develop breast cancer, compared with about 12.5 percent of women in the general population.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: 2018Source: Materials Today: Proceedings, Volume 5, Issue 8, Part 3Author(s): C. Lakshmi Anand, A.M. Hima Vyshnavi, Gilu Francis, S. Karthikeyan, P. Sanjay Kumar, P.K. Krishnan NambooriAbstractThe somatic mutations in TP53 may be considered as one of the major genomic reasons behind breast and ovarian cancers. These two types of cancers have been reported as the major terminal diseases among women, with breast cancer as the second and ovarian cancer as the fifth cause of death as per the WHO reports last year. However, the proneness of the disease varies from trait to trait and even from person to person....
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
AbstractPurpose of ReviewResearch over the past 25  years has revealed much about the architecture of predisposition to breast and ovarian cancer. There is now a general understanding that there are three broad categories of germline variation that may increase risk. First, there are the “high-penetrance” genes associated with a relative risk f or cancer of greater than 5 and demonstrating an autosomal dominant pattern of inheritance. At the other end of the spectrum are “low-penetrance” common variants. These variants are associated with minor increases in risk (commonly less than a relative r...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
August is National Breastfeeding Month. According to the Office on Women’s Health, breastfed babies have lower risks during their childhood of obesity, ear infections, asthma and other conditions. Breast milk is rich in nutrients and easier for babies to digest than formula. Breastfeeding can help a mother’s health and healing following childbirth and leads to a lower risk of type 2 diabetes, certain types of breast cancer and ovarian cancer. Unfortunately, African American mothers have the lowest rates of starting and continuing to breastfeed their infant. See the Guide to Breastfeeding from the Office of...
Source: BHIC - Category: Databases & Libraries Authors: Tags: Children and Teens Minority Health Concerns Source Type: blogs
Abstract BMI-1 (B-lymphoma Mo-MLV insertion region 1) is a key protein partner in polycomb repressive complex 1 (PRC1) that helps in maintaining the integrity of the complex. It is also a key player in ubiquitination of histone H2A which affects gene expression pattern involved in various cellular processes such as cell proliferation, growth, DNA repair, apoptosis and senescence. In many cancers, Overexpression of BMI1correlates with advanced stages of disease, aggressive clinicopathological behavior, poor prognosis resistance to radiation and chemotherapy. BMI1 is emerging as a key player in EMT, chemo-resistance...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
In this study, we found that miR-1284 was downregulated in breast cancer tissues and cell lines compared to normal control cells. Moreover, we showed that overexpression of miR-1284 significantly inhibited the proliferation, migration and invasion of breast cancer cells while promoting apoptosis. In terms of mechanism, we found that transcription factor ZIC2 was a target of miR-1284 in breast cancer cells. Through luciferase reporter assay, we demonstrated their direct interaction. Besides, qRT-PCR and western blot also indicated that miR-1284 overexpression inhibited the protein levels of ZIC2 in breast cancer cells. More...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
ConclusionsAn individualised approach is required for every patient. The adverse effects of endocrine therapy should be weighed against the potential benefits of extended therapy to better inform decision-making.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
We examined the rates ofBRCA testing and RRBM from 1997 to 2016, and quantified trends before and after the Jolie op-ed.MethodsThis observational study of insurance claims data representative of the commercially-insured US population (Truven MarketScan ® database) measuredBRCA testing and RRBM rates among females  ≥ 18 years. Censoring events were breast cancer or ovarian cancer diagnosis, last follow-up date (September 2016), or death. Interrupted time series analyses were used to quantify trends before and after the op-ed.ResultsAngelina Jolie ’sNYT op-ed led to a statistically significant...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Purpose of review Poly (ADP-ribose) polymerase inhibitors (PARPi) are approved drugs for the treatment of ovarian and breast cancer and currently under investigation for the treatment of prostate cancer and other malignancies with aberrations in homologous recombination DNA repair. This review summarizes literature published during 2017 concerning the relevance of PARPi in prostate cancer and presents new evidence on mechanisms of resistance and biomarkers of response. Recent findings The approval of several PARPi (olaparib, rucaparib, and niraparib) has driven the focus of anticancer treatment on synthetic lethality...
Source: Current Opinion in Supportive and Palliative Care - Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad Source Type: research
ConclusionThe multi-mechanisms of lncRNA ZFAS1 fertilizes its role of potential clinical biomarkers and therapeutic targets.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionOur findings suggest that coffee and/or caffeine may be associated with reduced risk of endometrial cancer but, probably, associated increased with risk of breast cancer among premenopausal or normal weight women. However, further studies are needed to confirm our findings.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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