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Parents sue for daughter to use medical marijuana

An 11-year-old girl with leukemia suffers seizures due to years of chemotherapy. Her parents are suing the Chicago school district for banning her use of medical marijuana.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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ConclusionIt is suggested that the laboratories using the hematology analyzers be aware of graphic display patterns in addition to flaggings generated which provide additional information and give clue toward the diagnosis even before peripheral smear examination.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Tags: RESEARCH ARTICLE Source Type: research
In this study, we investigated the presence and functionality of EpoR, as well as the implications of Epo upon the proliferation and survival of lung cancer cells. Since the protein expression of both Epo and EpoR is induced by hypoxia, which is frequently present in lung cancer, the cells were treated with Epo under both normoxic and hypoxic conditions (1% O2). By using quantitative (real-time) PCR, western blot analysis, and immunocytochemical staining, three non-small cell lung cancer (NSCLC) cell lines (A427, A549 and NCI-H358) were analyzed for the expression of EpoR and its specific downstream signaling pathways [Jan...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
It took a team of UCLA medical professionals and the generosity of 71 strangers to save 2-year-old Skye Savren-McCormick ’s life.The toddler from Ventura, California, required frequent blood and platelet transfusions, often on a daily basis, while undergoing  three grueling bone-marrow transplants, surgery to remove her swollen spleen and seven rounds of chemotherapy for leukemia and lymphoma. She received 77 units of blood and platelets during a 10-month stay at UCLA Mattel Children ’s Hospital.  Recently Skye ’s family got to meet and thank two dozen of the 71 strangers whose blood a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Authors: Klein K, de Haas V, Kaspers GJL Abstract INTRODUCTION: Although the prognosis of pediatric acute myeloid leukemia (pAML) has improved, with current survival rates up to 75%, relapse rates remain high. Areas covered: The low number of patients, the heterogeneous genomic landscape of AML, novel diagnostic techniques, divergent available treatment protocols, and dose-limiting toxicity of conventional agents all contribute to the complexity of AML treatment. This review gives an overview of the current clinical challenges with respect to diagnostics, treatment, and supportive care in pAML. Expert Commentary: D...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
CONCLUSION: We demonstrated high expression levels of GM-CSFR and G-CSFR, as well as their promotable role for viability in ph + ALL cells. We further found that rhG-CSF influenced the sensitivity of SUP-B15 cells to TKIs. PMID: 29338593 [PubMed - as supplied by publisher]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
CONCLUSION: Relative immunosuppression due to maintenance therapy for B-ALL can lead to lymphomatoid granulomatosis. PMID: 29336635 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
We describe three cases of sinusoidal obstruction syndrome/venoocclusive disease (SOS) in pediatric patients with acute lymphoblastic leukemia (ALL). All three episodes occurred during or just after the induction or reinduction phase of treatment based on prednisone/dexamethasone, vincristine, daunorubicin, and pegylated‐l‐asparaginase. SOS episodes were categorized as mild/moderate and resolved in 7, 10, and 16 days using supportive measures or defibrotide therapy. In all three episodes, the clinical diagnosis of SOS was associated with a significant increase in plasminogen‐activator inhibitor‐1 (PAI‐1) that red...
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: BRIEF REPORT Source Type: research
ier B, Michel G Abstract The prevalence of the metabolic syndrome among adults from the French childhood acute leukemia survivors' cohort was prospectively evaluated considering the type of anti-leukemic treatment received, and compared with that of controls. The metabolic profile of those patients was compared with that of controls. 3203 patients from a French volunteer cohort were age- and sex-matched 3:1 to 1025 leukemia survivors (in both cohorts, mean age: 24.4 years, female individuals: 51%). Metabolic syndrome was defined according to the National Cholesterol Education Program's Adult Treatment Panel III cr...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM have now found that just how big a role Myc plays is determined by a distant section of DNA that contains a cluster of gene enhancers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia, Published online: 17 January 2018; doi:10.1038/nature25186Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy.
Source: Nature AOP - Category: Research Authors: Source Type: research
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