Divalproex sodium modulates nuclear localization of ataxin-3 and prevents cellular toxicity caused by expanded ataxin-3.

CONCLUSION: Our study provides novel insights into the mechanisms of action of divalproex sodium as a possible treatment for SCA3, beyond the known regulation of transcription.
PMID: 29318784 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - January 9, 2018 Category: Neuroscience Authors: Wang ZJ, Hanet A, Weishäupl D, Martins IM, Sowa AS, Riess O, Schmidt T Tags: CNS Neurosci Ther Source Type: research