An innovative PET tracer can measure damage from multiple sclerosis in mouse models
(University of Chicago Medical Center) In the Jan. 12, 2018, Scientific Reports, a research team describes early tests of a minimally-invasive way to assess myelin damage -- the hallmark of multiple sclerosis -- using positron emission tomography (PET). This approach could be used to follow MS lesions over time.
ConclusionNo difference in postural venous outflow between patients with MS and healthy controls was found. However, when the abnormal ΔCVF is present within the MS population, it may be associated with more inflammatory and neurodegenerative pathology. Further studies should explore whether the orthostatic venous changes are an aging or an MS-related phenomenon and if the etiology is due to impaired autonomic nervous system funct ioning.
Tumefactive demyelinating lesion (TDL) is often reported as a rare variation of multiple sclerosis (MS). TDL is difficult to diagnose solely by magnetic resonance imaging (MRI) in patients with no history of MS. This is because the lesion often shows ring enhancement with perifocal brain edema on gadolinium MRI, thus mimicking glioblastoma multiforme (GBM).
ConclusionsOur data suggest radiological criteria can be useful to separate MS from MOG- and aquaporin-4-positive neuromyelitis optica spectrum disorders, in particular in patients with optic neuritis. Further work is needed to support their use in CIS.
Acta Neurologica Scandinavica,Volume 0, Issue ja, -Not available-.
AbstractObjectiveTo evaluate volumetric changes and discriminative power of intra-retinal layers in early-stage multiple sclerosis (MS) using a 3D optical coherence tomography (OCT) imaging method based on an in-house segmentation algorithm.Methods3D analysis of intra-retinal layers was performed in 71 patients with early-stage MS (mean disease duration 2.2 ± 3.5 years) at baseline and 40 healthy controls (HCs). All patients underwent a follow-up OCT scan within 23 ± 9 months. Patients with a clinical episode of optic neuritis (ON) more than 6 months prior to study ...
The objective of this study was to review how PPMS patients should be assessed and cared for in Latin America (LATAM).
Publication date: Available online 31 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Giancarlo Coghe, Giuseppe Fenu, Lorena Lorefice, Erica Zucca, Micaela Porta, Giuseppina Pilloni, Federica Corona, Jessica Frau, Maria Giovanna Marrosu, Massimiliano Pau, Eleonora CoccoAbstractIntroduction: Cognitive motor interference (CMI) is performance impairment due to simultaneuous task execution and is measured using the dual task cost (DTC). No pathological feature of MS has to date been associated with CMI.Aim: To assess the relationship between brain volumes and CMI, as measured using the DTC, in a cross-secti...
ConclusionFor ASPECTS assessment, the examined software may provide valid data in case of normal brain. It may enhance the work of neuroradiologists in clinical decision making. A final human check for plausibility is needed, particularly in patient groups with pre-existing cerebral changes.
Publication date: Available online 27 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Alon Kalron, Roy Aloni, Gilles AllaliAbstractAlthough falls, cognitive impairments and mood disorders are very common in people with MS (PwMS) the relationship between these conditions has received scant attention. Therefore, the purpose of the study was to investigate the specific involvement of depression and anxiety on cognition and falls in PwMS. The study included 122 PwMS (75 women) divided into four subgroups according to their manifestation of depression and anxiety assessed by the Hospital Anxiety and Depressi...
Authors: Brugarolas P, Reich DS, Popko B Abstract Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al's study 1 , we describe the development of the first PET tracer for voltage-gated K+ channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models. PMID: 30039728 [PubMed - in process]