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An innovative PET tracer can measure damage from multiple sclerosis in mouse models

(University of Chicago Medical Center) In the Jan. 12, 2018, Scientific Reports, a research team describes early tests of a minimally-invasive way to assess myelin damage -- the hallmark of multiple sclerosis -- using positron emission tomography (PET). This approach could be used to follow MS lesions over time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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By Christian Jarrett Three years ago, in a time before Trump or Brexit or This Is America, someone posted an overexposed photograph of a black and blue striped dress on Tumblr. Soon millions of people had seen it and started arguing about it. The reason? It quickly became apparent that about half of us – more often women and older people – perceive the dress, not as black and blue, but white and gold. In a neat example of real life echoing a classic psychology experiment (I’m referring to Asch), #thedress was enough to make you think your friends were gas lighting you – how could it be tha...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Cognition Feature Perception Source Type: blogs
Conclusions: Our study demonstrates that the DCE-MRI with the extended Tofts linear model can measure the permeability and perfusion characteristic in MS lesions and in NAWM regions. The Ktrans, Ve, Vp, CBF, and CBV of CE lesions were significantly higher than that of NE lesions. The skewness of Ve value in CE lesions was more close to normal distribution, indicating that the histogram can be helpful to distinguish the pathology of MS lesions.
Source: Neurology India - Category: Neurology Authors: Source Type: research
Conclusion This study shows that in the setting of a 1.5 T magnet field, STIR significantly has a superiority over both of the PSIR reconstructions (i.e. real and magnitude) for the detection as well as the boundary definition of the cervical cord lesions of MS. These results have a good relevance to clinical practice by using MRI scanners and sequences routinely available, however, it is discrepant with other reports performed by 3 T Magnet fields.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
AbstractBackgroundSeveral studies have shown an association between 25-hydroxyvitamin D (25[OH]D) levels and multiple sclerosis (MS) susceptibility and/or level of disease activity in patients treated with first line drugs.AimsTo investigate whether baseline 25[OH]D values could influence disease activity also during treatment with the second-line drug fingolimod (FTY).Patients and methodsWe enrolled 176 MS patients who started FTY at the San Raffaele Hospital (OSR) MS center with available 25[OH]D measurement at the time of treatment start. We then prospectively followed them for 2  years with periodic clinical exami...
Source: Neurological Sciences - Category: Neurology Source Type: research
Acta Neurologica Scandinavica, EarlyView.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Source Type: research
Acta Neurologica Scandinavica, EarlyView.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Source Type: research
CONCLUSIONS: There is a strong correlation between the two tomography scans in the measurement of the thickness of the RNFL in patients with MS, with and without a history of ON. Time-domain OCT quantifies greater thicknesses, and therefore both types of tomography have proven to be effective in the study of MS, although the results cannot be interchanged or extrapolated. PMID: 29696616 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
___ Time for SharpBrains eNewsletter, bringing you the latest in in brain health and mental health research, tools and thinking. Also, a quick heads-up for those based in the UK: the Imperial College Centre for Neurotechnology will host a keynote by Alvaro Fernandez in London on Wednesday, May 30th, titled Why the Future of Brain Enhancement & Mental Health is Digital & Pervasive (free; requires registration). Other upcoming events here. New research: Study finds continued birth of new neurons (neurogenesis) well into our 70s The more hours you sit per day, the smaller your med...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology app brain Brain-health brain-scans brain-stimulation Brainnovations Cognitive-Training meditation Mental-Health Neurogenesis Neurotechnology smartphone Source Type: blogs
Conclusions: The brain health index is a new image analysis approach that may usefully capture combined visible brain damage in large-scale studies of ageing, neurovascular and neurodegenerative disease. The Study in Context: Next: Brain scans to identify children at high risk of developing multiple sclerosis (MS) before symptoms appear 25 Key Resources to Improve Brain Health and Mental Health Five reasons the future of brain enhancement is digital, pervasive and (hopefully) bright 10 neurotechnologies about to transform brain enhancement and brain health What are cognitive abilities and how to boost them? Solving ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology atrophy brain health index Brain-health brain-injury cerebral small vessel diseases cognition computer-assisted image processing magnetic resonance imaging stroke Source Type: blogs
CONCLUSION: Even if cutaneous CD30+ lymphoproliferative disorders occur only rarely during fingolimod treatment, dermatologists should nevertheless be aware of this association for which strict dermatological surveillance is required. We would also stress that these CD30+ lymphoproliferative disorders can disappear spontaneously, as in our case, even if treatment by fingolimod is continued. PMID: 29673751 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
More News: International Medicine & Public Health | Multiple Sclerosis | PET Scan