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An innovative PET tracer can measure damage from multiple sclerosis in mouse models

(University of Chicago Medical Center) In the Jan. 12, 2018, Scientific Reports, a research team describes early tests of a minimally-invasive way to assess myelin damage -- the hallmark of multiple sclerosis -- using positron emission tomography (PET). This approach could be used to follow MS lesions over time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Source: European Journal of Neurology - Category: Neurology Authors: Tags: Editorials Source Type: research
Abstract PURPOSE: To simultaneously image brain lesions and veins in multiple sclerosis. METHODS: An interleaved sequence was developed to simultaneously acquire 3-dimensional T2*-weighted (or susceptibility-weighted (SW)) and fluid-attenuated inversion recovery (FLAIR) images on a 3T MRI system. The pulse sequence parameters were calculated to minimize signal perturbation from steady state while maintaining acceptable image contrast and scan time. Fifteen multiple sclerosis patients were enrolled in this prospective study and underwent a standard multiple sclerosis imaging protocol. In addition, SW and FLAIR...
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Magn Reson Med Source Type: research
PurposeTo simultaneously image brain lesions and veins in multiple sclerosis. MethodsAn interleaved sequence was developed to simultaneously acquire 3‐dimensional ‐weighted (or susceptibility‐weighted (SW)) and fluid‐attenuated inversion recovery (FLAIR) images on a 3T MRI system. The pulse sequence parameters were calculated to minimize signal perturbation from steady state while maintaining acceptable image contrast and scan time. Fifteen multiple sclerosis patients were enrolled in this prospective study and underwent a standard multiple sclerosis imaging protocol. In addition, SW and FLAIR images were acquired...
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Note Source Type: research
Abstract BackgroundWhether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate. MethodWe prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1‐year longitudinal study, together with 55 matched healthy controls at baseline. Participants were tested for memory performance and scanned with 3 T MRI to assess the volume of 5 distinct hippocampal subfields using automatic segmentation techniques. ResultsAt baseline, CA4/dentate gyrus was the only hippocampal sub...
Source: Human Brain Mapping - Category: Neurology Authors: Tags: RESEARCH ARTICLE Source Type: research
Combining PET scans with a novel radiotracer could help researchers track damage...Read more on AuntMinnie.comRelated Reading: Did PET scan confirm CTE in living NFL player? PET, EEG show treatment effectiveness in comatose patient PET links low serotonin levels to dementia SNMMI: PET helps track neuroinflammation in MS fMRI uncovers benefits of video games for MS patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractIntroductionThe MRI evidence of persistent black holes (pBHs) on T1-weighted images reflects brain tissue loss in multiple sclerosis (MS). The evolution of contrast-enhancing lesions (CELs) into pBHs probably depends on the degree and persistence of focal brain inflammation. The aim of our retrospective study was to evaluate the effect of a single cycle of intravenous methylprednisolone (IVMP), as for MS relapse treatment, on the risk of CELs ’ evolution into pBHs.Patients and methodsWe selected 57 patients with CELs on the baseline MRI scan. We evaluated the evolution of CELs into pBHs on a follow-up MRI sca...
Source: Journal of Neurology - Category: Neurology Source Type: research
ConclusionAlthough nearly half of the Dutch MS multiplex families reported an AID, no excess of AIDs was present in patients with MS from multiplex families or their first‐degree family members compared to the spouses.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions. LMCE was shown to be an independent and significant biomarker of grey matter atrophy and disability in MS. PMID: 29291134 [PubMed]
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
ConclusionsGrey matter is very much involved in the RRMS and cortical morphometric changes occur in a  non-uniform pattern and are very likely to be associated with cortical iron deposition and magnetic susceptibility, dGM atrophy, WM T2 lesion load, and disability.
Source: Clinical Neuroradiology - Category: Neurology Source Type: research
AbstractPurposeThe aim of our study is to identify radiological patterns of cortical gray matter atrophy (CGMA) that correlate with disease duration in patients with relapsing-remitting multiple sclerosis (RRMS).MethodsRRMS patients were randomly selected from the Sheba Multiple Sclerosis (MS) center computerized data registry based on stratification of disease duration up to 10  years. Patients were scanned by 3.0 T (Signa, GE) MRI, using a T1 weighted 3D high resolution, FSPGR, MS protocol. Neurological disability was assessed by the Expanded Disability Status Scale (EDSS). FreeSurfer was used to obtain brain v...
Source: Neuroradiology - Category: Radiology Source Type: research
More News: International Medicine & Public Health | Multiple Sclerosis | PET Scan