An innovative PET tracer can measure damage from multiple sclerosis in mouse models

(University of Chicago Medical Center) In the Jan. 12, 2018, Scientific Reports, a research team describes early tests of a minimally-invasive way to assess myelin damage -- the hallmark of multiple sclerosis -- using positron emission tomography (PET). This approach could be used to follow MS lesions over time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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In this study, we analyzed the effect of intensity domain adaptation on our recently proposed CNN-based MS lesion segmentation method. Given a source model trained on two public MS datasets, we investigated the transferability of the CNN model when applied to other MRI scanners and protocols, evaluating the minimum number of annotated images needed from the new domain and the minimum number of layers needed to re-train to obtain comparable accuracy. Our analysis comprised MS patient data from both a clinical center and the public ISBI2015 challenge database, which permitted us to compare the domain adaptation capability of...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 3 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Ji Zhou, Xiaopeng Lu, Yao Zhang, Taoyun Ji, Yiwen Jin, Min Xu, Xinhua Bao, Yuehua Zhang, Hui Xiong, Xingzhi Chang, Yuwu Jiang, Ye WuABSTRACTBackgroundSome studies have reported clinical features of relapsing MOG-IgG-associated CNS demyelination principally in Caucasians children. It is not clear whether Chinese children share the same phenotype.ObjectiveTo delineate the clinical characteristics in Chinese children with relapsing MOG-IgG-associated demyelination.MethodsA follow-up study on 23 Children with relapsing ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Abstract INTRODUCTION: The course of multiple sclerosis is characterised by the development of cerebral atrophy. It is of interest to monitor it in order to evaluate the treatment response, and the preferred technique consists in performing brain volume analyses, which are currently restricted to the field of research. AIM: To analyse the corpus callosum index (CCI) as a possible alternative to the methods based on brain segmentation. SUBJECTS AND METHODS: Our sample was made up of 109 patients with recently diagnosed demyelinating diseases (90 relapsing-remitting multiple sclerosis, 7 primary progressiv...
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
ConclusionsThere are regional differences in MS epidemiology in Finland, possibly related to demographic, social and genetic circumstances but the retrospective nature and limited sample size of this study might introduce some uncertainty to the calculations. SwF is a region with a globally very high risk for MS.This article is protected by copyright. All rights reserved.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: Original Article Source Type: research
Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume. PMID: 30468125 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research
ConclusionsThose with MS ‐related mobility disability who have the lowest aerobic fitness, walking speed and CPS might benefit the most from multimodal exercise‐training. This provides critical evidence for informing the development of a precision medicine framework for improving targeted outcomes with exercise‐traini ng in MS.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsAccording to our data, elevated serum autoantibodies do not have the potential to serve as a prognostic tool for disease severity in patients with MS. Since MS patients with positive serum AABS did not significantly more often suffer from clinical manifest AIs than MS patients with negative serum AABS, the role of routine testing of serum AABS in MS patients should be critically called into question.This article is protected by copyright. All rights reserved.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Synthetic and conventional phase-sensitive inversion recovery have a sensitivity similar to that of leukocortical MS lesions. The detected leukocortical lesions are associated with cognitive dysfunction and thus provide clinically relevant information, which encourages assessment of cortical MS involvement at conventional field strengths.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
CONCLUSIONS: Because all enhancing lesions were associated with new lesions on unenhanced imaging and progression was only evident in 24% of patients, in patients with relapsing-remitting MS, it is reasonable to consider reserving contrast for only those patients with evidence of progression on noncontrast MR images.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
Publication date: Available online 13 November 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): C. Vinciguerra, A. Giorgio, J. Zhang, I. Di Donato, M.L. Stromillo, R. Tappa Brocci, A. Federico, M.T. Dotti, N. De StefanoAbstractBackgroundPeak width of skeletonized mean diffusivity (PSMD) is a novel and fully automated, MRI biomarker, which has shown clinical relevance in cerebral small vessel diseases (SVD). We aimed here to assess PSMD levels across the brain of patients with multiple sclerosis (MS), in comparison to normal controls (NC) and patients with CADASIL, a genetically defined form of severe SVD.Meth...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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