Association between the Intron 8 VNTR Polymorphism of the DAT1 Gene and Crack Cocaine Addiction

Conclusions: Our results are consistent with the role ofDAT1 in the neurobiology of drug addiction. Nevertheless, the study of other genes, environmental factors, and their interactions is also important to gain a broader understanding of this condition.Neuropsychobiology 2017;75:141 –144
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research

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Breast cancer is the leading diagnosed cancer for women globally. Evolution of breast cancer in tumorigenesis, metastasis and treatment resistance appears to be driven by the aberrant gene expression and protein degradation encoded by the cancer genomes. The uncontrolled cancer growth relies on these cellular events, thus constituting the cancerous programs and rendering the addiction towards them. These programs are likely the potential anticancer biomarkers for Personalized Medicine of breast cancer. This review intends to delineate the impact of the CRSPR/Cas-mediated genome editing in identification and validation of t...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusions: The cells rely more on glucose/gltamine have a stronger sensitivity to glucose/glutamine depletion or glycolysis/ glutaminolysis inhibition and a lessened sensitivity to glutaminolysis/glycolysis inhibitors. To target tumor metabolism based on metabolic characteristics may provide a new therapeutic strategy for the treatment of B cell lymphoma.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Background: The Zusanli (ST36) acupoint has been associated with treatment of various gastrointestinal conditions. There have been no studies of acupuncture therapy for paralytic postoperative ileus (PPOI).Materials and methods: Patients with PPOI following gastrectomy for gastric cancer were randomized to receive ST36 acupoint injection with neostigmine, gluteal intramuscular injection with 1.0 mg neostigmine, ST36 acupuncture alone, or standard therapy. The main outcome was the effectiveness rate for recovery of peristalsis. Secondary outcomes were time to bowel sound recovery, time to first flatus, and time to first def...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
NHS boss Simon Stevens noted that young people come to think of smoking marijuana as safe in countries where it has been decriminalised.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Lauren Neville, 30, from Burnley, Lancashire, whose 10 daily seizures were initially dismissed as depression, discovered she had a 6cm  tumour after having a fit behind the wheel last January.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Limited access and fragmentation of mental health care for children and adolescents have been longstanding and well-articulated issues for decades. Increasing suicide rates, especially in the younger age groups, violence in schools, and substance use issues have all been highlighted as particular concerns. Despite receiving much attention of various types, including recommendations by professional organizations, excellent initiatives for screening, as well as collaborative programs with primary care and schools, the number of youths presenting in psychiatric crisis to emergency services continues to increase.
Source: Child and Adolescent Psychiatric Clinics of North America - Category: Psychiatry Authors: Tags: Preface Source Type: research
And what to do about it.
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Researchers from the University of Pittsburgh found that for every 10 percent increase in negative social media experiences, people's risk of depression rises by 20 percent.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Pyometra is a common disease in dogs and cats. Hormones and opportunistic bacteria are fundamental in the development, with progesterone playing a key role. The disease should be suspected in intact bitches and queens presenting with illness, and particularly if within 4  months after estrus. Early diagnosis and treatment are vital to increase chances of survival as endotoxemia and sepsis often are induced. Typical clinical signs include vaginal discharge, depression, anorexia, polyuria and polydipsia, fever and gastrointestinal disturbances. Surgical ovariohystere ctomy is the safest and most effective treatment. For...
Source: Veterinary Clinics of North America: Small Animal Practice - Category: Veterinary Research Authors: Source Type: research
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Cliniciansâ Source Type: research
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