Both Serum Brain-Derived Neurotrophic Factor and Interleukin-6 Levels Are Not Associated with Therapeutic Response to Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder

Conclusion: The present study suggests that the acute effect of lamotrigine augmentation therapy for a major depressive episode is not related to either BDNF or IL-6, at least in patients with treatment-resistant depressive disorder.Neuropsychobiology 2017;75:145 –150
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research

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CONCLUSIONS: Possibly, the individuality of specific animals and their unique responses to a variety of stimuli and drugs, can be helpful in deciphering the underlying biology of affective behaviors as well as offer better prediction of drug responses in patients. PMID: 29909818 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Publication date: Available online 18 June 2018 Source:The Lancet Psychiatry Author(s): Trine Munk-Olsen, Xiaoqin Liu, Alexander Viktorin, Hilary K Brown, Arianna Di Florio, Brian M D'Onofrio, Tara Gomes, Louise M Howard, Hind Khalifeh, Holly Krohn, Henrik Larsson, Paul Lichtenstein, Clare L Taylor, Inge Van Kamp, Richard Wesseloo, Samantha Meltzer-Brody, Simone N Vigod, Veerle Bergink Background Concerns about teratogenicity and maternal and offspring complications restrict the use of lithium during pregnancy for the treatment of mood disorders. We aimed to investigate the association between in-utero lithium exposure an...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
The term postpartum depression is used generically to denote occurrence of a depressive episode after childbirth. Emerging research suggests that bipolar disorder is common among women with postpartum depression. Due to the lack of awareness of its existence, bipolar postpartum depression is often misdiagnosed as major depressive disorder, causing long delays for women to receive appropriate treatment. We hypothesize that screening all women with postpartum depression for bipolar disorder would help correctly identify subgroups of women based on the underlying psychiatric diagnosis.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research
Transcriptional profiling of postmortem brain tissue provides detailed insight into the molecular and cellular basis of psychiatric illnesses that cannot be achieved in living patients. A recent large-scale analysis of cortical gene transcriptome profiles across five major psychiatric diseases revealed pathways of molecular convergence and specificity (1). Interestingly, bipolar disorder had more transcriptional overlap with schizophrenia than major depressive disorder (MDD). Furthermore, while autism spectrum disorder showed some genetic overlap with schizophrenia and bipolar disorder, it showed its own module-level diffe...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Bipolar Disorders, EarlyView.
Source: Bipolar Disorders - Category: Psychiatry Authors: Source Type: research
Bipolar disorder (BD) is a psychiatric disorder characterized by episodes of depression and (hypo)mania. The estimated lifetime prevalence across Europe is 1.5-2%, with a lifetime prevalence of 1.3% for bipolar I disorder in the Netherlands (de  Graaf, ten Have, van Gool,&van Dorsselaer, 2012). Globally, bipolar disorder is ranked sixth among the causes of Disability-Adjusted Life Years (DALY) between the ages of 15 to 44 years, is an important cause of a decline in the health-related quality of life (IsHak  et al., 2012), and is associated with a high burden of social and occupational stress (Pini ...
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
There is a seminal article by Barbara Fredrickson titled ‘What good are positive emotions?’ which introduces the broaden-and-build theory of positive emotions. As per this theory, while negative emotions are associated with specific action tendencies, positive emotions broaden the thought-action repertoire available at that moment and help build physical, social and intellectual resources over the long run. To take an example, joy is associated with creativity, and more loose associations, etc, all involving a move away from rigidity and fixedness to flexibility and fluency in thinking ;  joy is also assoc...
Source: The Mouse Trap - Category: Psychiatry & Psychology Authors: Tags: emotion adaptations emotions evolution play Source Type: podcasts
The last three to four weeks for me have been extremely hard. I found myself in the grips of a deep depression. I am fortunate enough to no longer suffer from the deep devastating suicidal depression that once came with my bipolar depression, I am blessed in that way. However, nonetheless it is still a devastatingly life-halting depression that really makes life difficult to tolerate for a few weeks and difficult to carry on with my daily activities. My normal, everyday personality is more along the lines of a bubbly, happy person, and I tend to have a larger than life, over-the-top personality. These last few weeks thoug...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Depression Personal Depressive Episode Suicidal Ideation Source Type: blogs
Happy Saturday, Psych Central readers! If you’re having the kind of weekend we are here in my neck of the woods (i.e. 90+ degree weather — whew!), take a break inside and cool down while you catch up on some of the latest in mental health this week including the psychology behind being hangry, how you can use persistent regrets to change your present life, the connection between Bob Ross and relaxation (and we’re not talking painting, here), and more! Feeling Hangry? New Study Explains The Psychology Why People Get Angry When Hungry: The Oxford English Dictionary recently accepted the word “hangry,&...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anger Bipolar Children and Teens Disorders Medications Psychology Around the Net Research Sleep Technology Bipolar Disorder Bob Ross Calm Cannabis hangry Lithium meditation app mental illness in seniors pediatric bipolar Source Type: blogs
 The Depression and Bipolar Support Alliance (DBSA) has received additional funding from the GMR to continue efforts to support youth living in medically underserved areas with a mental health condition. The How to Maximize Your Health Insurance Benefits program is designed to reach out to professional youth influencers, such as social workers, librarians and school personnel through a 4-hour workshop that provides continuing education credits. This program builds upon last year’s award, Improving Health Information Literacy and Access to Mental Health Care. 
Source: The Cornflower - Category: Databases & Libraries Authors: Tags: Consumer Health Funding News from the Region Success Stories Depression and Bipolar Support Alliance Source Type: news
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