Both Serum Brain-Derived Neurotrophic Factor and Interleukin-6 Levels Are Not Associated with Therapeutic Response to Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder

Conclusion: The present study suggests that the acute effect of lamotrigine augmentation therapy for a major depressive episode is not related to either BDNF or IL-6, at least in patients with treatment-resistant depressive disorder.Neuropsychobiology 2017;75:145 –150
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research

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Authors: Chao PC, Chang CC, Chang HA Abstract Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present a female with bipolar II depression who rapidly developed hypomanic switching during bifrontal tDCS. PMID: 30235920 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSION: These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern. PMID: 30235919 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
New research finds that the hypothalamus, the brain area that controls the stress response, is larger in people with affective disorders.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Publication date: Available online 22 September 2018Source: Social Science &MedicineAuthor(s): Charis Lengen, Christian Timm, Thomas KistemannAbstractThe ability to remember, recognize and reconstruct places is a key component of episodic autobiographical memory. In this respect, place forms an essential basis for the unfolding of experiences in memory and imagination. The autobiographical memory is seen to contribute to a sense of self and place identity.The aim of this study was to concertedly analyze paintings, autobiographical narrations and places of birth and life of clients under treatment at a psychiatric clini...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
BACKGROUND: The medical burden in mood disorders is high; various factors are thought to drive this pattern. Little research has examined the role of childhood maltreatment and its effects on medical morbidity in adulthood among people with unipolar depres...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
CONCLUSIONS: These findings suggest that childhood maltreatment may play a stronger role in the development of medical illnesses in individuals with bipolar disorder relative to those with unipolar depression. Individuals who had been maltreated with a mood disorder, especially bipolar disorder may benefit most from prevention and intervention efforts surrounding physical health.Declaration of interestNone. PMID: 30232950 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
By Alex Fradera Every year three quarters of a million people take their own lives, and suicide is the leading cause of death in adolescents. Non-lethal self-harm is also prolific, leading annually to around 300,000 UK hospital visits, with even more going unreported. Knowing who is at most risk can inform support and prevention efforts. The higher rates of self-harm in LGBT and minority groups are well-established, and now a new review article in the British Journal of Clinical Psychology identifies other groups, including goths, emos and metalheads, who may also be at increased risk. The British team, led by Mairea...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Mental health Suicide/ self-harm Source Type: blogs
Bipolar disorder (BD), a severe, chronic psychiatric disease, is a leading cause of disability, morbidity, and mortality from suicide, and is associated with several medical conditions, such as cardiovascular disease, diabetes mellitus, and neurovascular disease (Merikangas et al., 2007; Prieto et al., 2014). It is characterized by episodes of depression, mania (BD I), and hypomania (BD II) that seriously affect the social functioning and quality of life of patients (Dean et al., 2004; Merikangas et al., 2007).
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
 Most of us spend a large portion of our days at work, where we’re exposed to all sorts of different stressors that take a cumulative toll. And many of us are already dealing with some sort of mental health issue unrelated to our jobs. Put together, it can be a recipe for a breakdown, which is why it’s so important to address mental health in the workplace. Host Gabe Howard shares his insights on the subject, including his story of being fired from a job due to his mental illness, and the ensuing years of exploring the nature of mental health at our places of employment. Subscribe to Our Show! An...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Industrial and Workplace Mental Health and Wellness The Psych Central Show Gabe Howard Vincent M. Wales Source Type: blogs
To critically examine the effectiveness of lithium in preventing depressive symptoms (mixed and depressive episodes) in real life settings, taking into account adherence to drug treatment and its implications for the clinical costs of the disease. Overall, 72 patients with bipolar disorder initially treated with lithium carbonate were included and followed-up for 10 years. Patients were assessed every 8 weeks for morbidity and alcohol/drug consumption. Patients with good adherence to lithium had fewer episodes with depressive features than poor adherers (B  = 2.405, p = 0.046) and also fewer manic and hypomanic epi...
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Source Type: research
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