Impact of prior malignancy on outcomes of stage IV esophageal carcinoma: SEER based study.

CONCLUSION: Prior malignancy does not adversely impact survival of stage IV esophageal cancer. These results should be taken into consideration when designing clinical trials. PMID: 29316808 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

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SummaryEndoscopic therapy is the gold standard for curative treatment of early esophageal adenocarcinoma (EAC) including dysplastic Barrett ´s epithelium (BE) and very early squamous cell carcinoma (SCC) because it is superior to surgery in regard to morbidity, mortality and cost effectiveness while yielding excellent results and low complication rates.Tumor detection at an early stage is often challenging and a multimodal approach using high resolution white light endoscopy, virtual chromoendoscopy (e.g. narrow band imaging, NBI) and endoscopic ultrasonography (EUS) is recommended. Importantly, histological diagnosi...
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 30 November 2018Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Ian Wong, Simon LawAbstractDespite the rise in incidence of adenocarcinoma, squamous cell cancer of the oesophagus remains the commonest cell type worldwide and is predominant in the East. Except for very early tumours where endoscopic therapy can be performed with curative intent, in more advanced but potentially curative cancers, treatment for mid and upper third tumours is primarily surgery with extended lymphadenectomy, together with multimodal therapies such as preoperative chemotherapy or chemora...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 23 November 2018Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Robert Charles Walker, Timothy James UnderwoodAbstractThe molecular pathways involved in the development and treatment of oesophageal cancer are complex. Recent large-scale genome sequencing studies have delivered novel insights into aetiology and possible targeted treatments. Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct entities. At the molecular level OSCC is more similar to squamous cell cancers in other organs than OAC. Whilst considerable heterogeneity exists in...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States.Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6.5 –7.1%. Causes include the increase in the in...
Source: Digestion - Category: Gastroenterology Source Type: research
Publication date: Available online 23 November 2018Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Robert Charles Walker, Timothy James UnderwoodAbstractThe molecular pathways involved in the development and treatment of oesophageal cancer are complex. Recent large-scale genome sequencing studies have delivered novel insights into aetiology and possible targeted treatments. Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct entities. At the molecular level OSCC is more similar to squamous cell cancers in other organs than OAC. Whilst considerable heterogeneity exists in...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 22 November 2018Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Shao-Hua Xie, Jesper LagergrenAbstractThe two main histological subtypes of oesophageal cancer, squamous cell carcinoma and adenocarcinoma, have distinct risk factor profiles. For oesophageal squamous cell carcinoma, tobacco smoking and excess alcohol use are the main risk factors. For adenocarcinoma, gastro-oesophageal reflux disease and obesity are main risk factors, whereas tobacco smoking is a moderately strong risk factor and infection with Helicobacter pylori decreases the risk. Dietary factors m...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 21 November 2018Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Paul M. Jeene, Hanneke W.M. van Laarhoven, Maarten C.C.M. HulshofAbstractDefinitive chemoradiation (dCRT) is a curative treatment option for patients with oesophageal cancer. It is effective in both adenocarcinoma and squamous cell carcinoma. However, locoregional control is less after dCRT compared to preoperative CRT (pCRT) followed by surgery. Also, overall survival is lower compared to pCRT followed by surgery, which can only partly be explained by a negative selection of patients.The optimal dose ...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionsAutoantibodies against an optimized TAA panel as serum biomarkers appear to help identify the present of early stage EJA.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
AbstractBackground.Gastroesophageal cancers are often grouped together even though cancers that originate in the esophagus often exhibit different histological features, geographical distribution, risk factors, and clinical characteristics than those originating in the stomach. Herein, we aimed to compare the molecular characteristics of three different gastroesophageal cancer types: esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric adenocarcinoma (GAC).Subjects, Materials, and Methods.In total, 3,342 gastroesophageal cancers were examined. Next‐generation sequencing was performed on...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Precision Medicine, Gastrointestinal Cancer Source Type: research
CONCLUSION: These findings indicate the potential and limitations of aspirin and aspirin analogues as chemotherapeutic agents against OC and CRC when combined with platins. PMID: 30417794 [PubMed - as supplied by publisher]
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research
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