Log in to search using one of your social media accounts:

 

Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance

Conclusions: We conclude that TDM is an effective method of achieving targeted Bu levels in children. QC programs are crucial to monitoring and maintaining the quality of an analytical method.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research

Related Links:

This study hypothesized that genetically engineered bone marrow derived mesenchymal stem cells (BMSCs) co-expressing IFN-γ and IL-10 can serve as a potential therapeutic strategy in the treatment of HCC by inhibiting cell proliferation. METHODS: Male Sprague-Dawley rats (n=5, 200-250 g) for BMSCs isolation and Nude/SCID mice (n=35,12-20g) to develop liver cancer xenograft model were used. Mice were subcutaneously injected HepG2 cell suspension on left flank. BMSCs were genetically engineered with the recombinant lentiviral vectors expressing IFN-γ and IL-10. The experiments were performed in 5 groups (phosp...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
ConclusionThis study provides first evidence that the CTLA-4 polymorphisms are significant risk factors for TRM and survival in children undergoing allogeneic HSCT and should be evaluated in further trials.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
A prospective, randomized evaluation of the feasibility of exergaming on patients undergoing hematopoietic stem cell transplantation, Published online: 15 January 2018; doi:10.1038/s41409-017-0070-8A prospective, randomized evaluation of the feasibility of exergaming on patients undergoing hematopoietic stem cell transplantation
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Prognostic relevance of DNMT3A R882 mutations in AML patients undergoing non-myeloablative conditioning hematopoietic stem cell transplantation, Published online: 15 January 2018; doi:10.1038/s41409-017-0060-xPrognostic relevance of DNMT3A R882 mutations in AML patients undergoing non-myeloablative conditioning hematopoietic stem cell transplantation
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Beneficial impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation: focusing on difference between stem cell sources, Published online: 15 January 2018; doi:10.1038/s41409-017-0045-9Beneficial impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation: focusing on difference between stem cell sources
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Using liver elastography to diagnose sinusoidal obstruction syndrome in pediatric patients undergoing hematopoetic stem cell transplant, Published online: 15 January 2018; doi:10.1038/s41409-017-0064-6Using liver elastography to diagnose sinusoidal obstruction syndrome in pediatric patients undergoing hematopoetic stem cell transplant
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party, Published online: 15 January 2018; doi:10.1038/s41409-017-0067-3Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Authors: Lin R, Wang Y, Ji K, Liu Z, Xiao S, Zhou D, Chen Q, Shi B Abstract Due to the lack of potential organs, hepatocellular transplantation has been considered for treating end-stage liver disease. Induced pluripotent stem cells (iPSCs) are reverted from somatic cells and are able to differentiate into hepatocytes. The present study aimed to investigate the mechanisms underlying iPSC differentiation to hepatocytes. GSE66076 was downloaded from the Gene Expression Omnibus; this database includes data from 3 undifferentiated (T0), 3 definitive endoderm (T5), and 3 early hepatocyte (T24) samples across hepatic‑d...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, we provide an approach to generate OLs in a very rapid and efficient manner, which can be used for disease modeling, drug discovery efforts, and potentially for therapeutic OL transplantation. Graphical abstract Teaser In this article, García-León JA and colleagues demonstrate the generation of functional oligodendrocytes (OLs) from human pluripotent stem cells in a rapid and efficient manner by the single overexpression of SOX10. Generated OLs resemble primary OLs at the transcriptome level and can myelinate neurons both in vivo and in vitro. Neuron-OL co-cultures, adapted to high-th...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 11 January 2018 Source:Stem Cell Reports Author(s): Alina Garbuzov, Matthew F. Pech, Kazuteru Hasegawa, Meena Sukhwani, Ruixuan J. Zhang, Kyle E. Orwig, Steven E. Artandi Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface receptor GFRα1. Technical challenges in isolation of GFRα1+ versus GFRα1– undifferentiated spermatogonia have precluded the comparative molecular characterization of these subpopulations and their functional evaluation as stem cells. Here, we ...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
More News: Children | Drugs & Pharmacology | Pediatrics | Stem Cell Therapy | Stem Cells | Transplants