IL-27: Friend or Foe in the Autoimmune Diseases
Conclusions: The functions of IL-27 are currently unclear because it appears to affect different cells, cytokines, and signaling pathways differently. Further investigations are needed to clarify the role of IL-27 in autoimmune diseases. Hence, this article reviewed the multiple roles of IL-27 in autoimmune diseases and describe the influence of IL-27 on the immune system.
TYPE 2 diabetes symptoms can be difficult to detect because they don ’t always make a person feel unwell. Feeling thirsty all the time is one of the signs, but there are also four toilet habits you should note.
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Insulia Diabetes Management Companion
ConclusionsHPV prevalence in the oral mucosa of the assessed FA patients was higher than reported in the general population. Additional studies with collection of sequential samples are needed to know the natural history of the presence of multiple HPV types in these individuals and its association with the development of tumors, to evaluate the implementation of preventive measures, such as vaccination, and to guide early treatment.This article is protected by copyright. All rights reserved.
ConclusionsFinancial incentives are useful for engaging Medicaid enrollees in disease prevention programs, but program engagement may not necessarily lead to changing patterns of healthcare utilization and expenditures in the short run.
This article reviews the new developments in RA research and discusses the latest insights into epidemiology, risk factors, predisease states, and outcomes.
Authors: Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L Abstract The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitilig...
CONCLUSION: The aim of this review, other than providing a summarized update on the clinical knowledge on this special topic, is also to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate the use of biologics in these special patient categories and therefore draw definite conclusions on their safety profile. PMID: 30428753 [PubMed - as supplied by publisher]
This study aims to assess ligament lesions and subluxations of the carpometacarpal (CMC) joint of the thumbs and the role that these ligament ruptures play in the pathophysiology of osteoarthritis (OA). Twenty-five fresh-frozen cadaver hands were dissected. There were 14 female and 11 male with mean age 65 years (51-92 years old). The origin, insertion, and fibre orientation of the ligaments were identified based on Berger´s anatomical descriptions. Length, thickness and width of the main ligaments were measured. The ligament ruptures and the metacarpal translation associated with these ruptures were measured (mm). C...