Dendritic Cells and Immunomodulation: Role in Health and Disease
Conclusions: The emergence of new classes of T-helper effector cells and their cytokines has led to a change in our understanding of therapeutic potentials of DCs. This has provided both new options and challenges for researchers involved in this field, and is likely to result in advancement in identifying and developing novel therapeutic measures and innovative strategies for several immunological chronic disorders.
We present bone scan findings in a case of erythromelalgia in an 18 years old student, in whom the symptoms developed suddenly. No underlying disease could be demonstrated and the patient fully recovered. The scan findings were strikingly similar to those of reflex sympathetic dystrophy. PMID: 30006649 [PubMed - as supplied by publisher]
Authors: Miao C, Zhang L, Sun M, Ma C Abstract A 3 years old boy was hospitalized with a month's history of polydipsia, polyuria and low fever. There was no relevant family history. This is a rare case of Langerhans cell histiocytosis (LCH) with both bone and pituitary infiltration shown on the technetium-99m methylene diphosphonate (99mTc-MDP) scan and brain magnetic resonance imaging (MRI). Sagittal and coronal T1-weighted images on MRI showed the typical lack of high signal intensity of the posterior pituitary which corresponded to the central signs of diabetes insipidus (DI). The diagnosis of LCH was suspected ...
CONCLUSIONS: We demonstrated that the eAAP presented improved asthma control outcomes, but as expected the sample size was inadequate to show a significant difference but based on this pilot study we plan a larger appropriately powered RCT. PMID: 30003851 [PubMed - as supplied by publisher]
CONCLUSIONS: The improvement in QoL and exacerbation rates with reslizumab are associated with high costs, making reslizumab unlikely to be cost-effective at the $200,000 WTP threshold. PMID: 30003833 [PubMed - as supplied by publisher]
CONCLUSIONS: Taking the social perspective, the economic impact of severe asthma in Spain was estimated to be €8554/patient/year. PMID: 30003827 [PubMed - as supplied by publisher]
This article reviews the early successes of anti-PD-1 therapies and adoptive T-cell therapies for metastatic anal cancer as a potential foundation for novel combination immunotherapy trials in the future. PMID: 30006430 [PubMed - in process]
Authors: Ettinger DS, Aisner DL, Wood DE, Akerley W, Bauman J, Chang JY, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower M, Govindan R, Gubens MA, Hennon M, Horn L, Lackner RP, Lanuti M, Leal TA, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel SP, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M Abstract The NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the targeted therapy and immunotherapy sections in the NCCN Guidelines. For the 2018 u...
CONCLUSION: The results supports that maximal voluntary contraction and potentiated twitch stimulation measurements of isometric quadriceps strength are reliable in people with severe to very severe chronic obstructive pulmonary disease as evident excellent relative reliability using both techniques, although the former technique appears to have better absolute reliability. PMID: 30004108 [PubMed - as supplied by publisher]
Authors: Niedźwiecki M, Budziło O, Zieliński M, Adamkiewicz-Drożyńska E, Maciejka-Kembłowska L, Szczepański T, Trzonkowski P Abstract CD4+CD25highCD127low/-FoxP3+ regulatory T cells (Tregs) are currently under extensive investigation in childhood acute lymphoblastic leukemia (ALL) and in other human cancers. Usually, Treg cells maintain the immune cell homeostasis. This small subset of T cells has been, in fact, considered to be involved in the pathogenesis of autoimmune diseases and progression of acute and chronic leukemias. However, whether Treg dysregulation in CLL and ALL plays a key role or it rather r...