Dendritic Cells and Immunomodulation: Role in Health and Disease
Conclusions: The emergence of new classes of T-helper effector cells and their cytokines has led to a change in our understanding of therapeutic potentials of DCs. This has provided both new options and challenges for researchers involved in this field, and is likely to result in advancement in identifying and developing novel therapeutic measures and innovative strategies for several immunological chronic disorders.
Triple therapy in a single inhaler reduces exacerbations in COPD more effectively than dual-inhaler comparators in a randomized trial, but experts question the study design.Medscape Medical News
Insulin and other treatments for type 2 diabetes do not impair bone metabolism, according to a new trial from Denmark.Reuters Health Information
The once-daily, single inhaler triple therapy is now indicated for a broader population of patients with COPD.FDA Approvals
Date: Friday, 04 27, 2018; Speaker: Richard N. Bergman, Director of Diabetes and Obesity Research Institute; Building: Building 10 (Clinical Center); FAES ROOM 1&2
Date: Tuesday, 06 05, 2018; Speaker: Paul A. Sieving, M.D., Ph.D., Director, National Eye Institute; Emily Y. Chew, M.D., Deputy Clinical Director, National Eye Institute; Philip Gorden, M.D., Director Emeritus, National Institute of Diabetes, Digestive, and Kidney Diseases; Lloyd Paul Aiello, M.D., Ph.D., Joslin Diabetes Center; Stuart Fine, M.D., University of Colorado; Leslie Hyman, Wills Eye Hospital; Anne Lindblad, Ph.D., The Emmes Corporation; Daniel Martin, M.D., Cleveland Clinic; Frederick L. Ferris III, M.D.; Building 45 (Natcher Building); Auditorium
Conclusion: Collectively, our results demonstrate that AFSCs may be a promising therapeutic treatment for ameliorating diabetes and the development of diabetic nephropathy and that the overexpression of SIRT3 in AFSCs may further increase the efficiency of stem cell-based therapy.Cell Physiol Biochem 2018;46:1508 –1524
As 4-year-0ld Elianna Grace sat in the back seat of the SUV, battling her second fever in three days, her mom flashed back to the coughing and vomiting fit the preschooler had the previous weekend — and to a niggling fear about the girl's sudden illness. Elianna had spent April 14 playing in her grandparents' […]Related:FDA cracks down on sales of Juul, other e-cigarettes to youthsInside the secret U.S. stockpile meant to save us all in a bioterror attackVeteran receives penis and scrotum transplant in surgery doctors say is a medical first
Conclusions: Mechanical circulatory support is an effective method of pulmonary hypertension treatment for patients disqualified for OHT due to high PVR. PMID: 29681957 [PubMed]
Authors: Schmalz G, Berisha L, Wendorff H, Widmer F, Marcinkowski A, Teschler H, Sommerwerck U, Haak R, Kollmar O, Ziebolz D Abstract BACKGROUND: Aim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT). MATERIAL AND METHODS: 169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and>10 years) and form of immunosuppre...
Authors: Gao C, Zhang X, Chen J, Zhao J, Liu Y, Zhang J, Wang J Abstract BACKGROUND: Tongue squamous cell carcinoma is the most common squamous cell carcinoma of the head and neck. Immunotherapy has great potential in the treatment of tongue squamous cell carcinoma because of its unique advantages. However, the efficacy of immunotherapy is limited by the efficiency of antigen phagocytosis by immune cells. MATERIAL AND METHODS: We extracted dendritic cells (DCs) from human peripheral blood. Utilizing a nanosecond pulsed electric field (nsPEF), we deliver the tumour lysate protein into DCs and then incubate the D...