Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms

Publication date: 20 April 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 83 Author(s): Xintian Yan, Xinzhi Zhao, Juxue Li, Lin He, Mingqing Xu Lines of evidence have demonstrated that early-life malnutrition is highly correlated with neurodevelopment and adulthood neuropsychiatric disorders, while some findings are conflicting with each other. In addition, the biological mechanisms are less investigated. We systematically reviewed the evidence linking early-life nutrition status with neurodevelopment and clinical observations in human and animal models. We summarized the effects of special nutritious on neuropsychiatric disorders and explored the underlying potential mechanisms. The further understanding of the biological regulation of early-life nutritional status on neurodevelopment might shed light on precision nutrition at an integrative systems biology framework.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research