Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01051
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research

Related Links:

Condition:   Asthma Interventions:   Drug: Masitinib;   Drug: Placebo Sponsor:   AB Science Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Merck and Bayer have been granted FDA Breakthrough Device Designation for the collaborative Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Artificial Intelligence Pattern Recognition software. CTEPH can be difficult to diagnose because its symptoms are similar to asthma and chronic obstructive pulmonary disease symptoms. CTEPH affects five people per million annually worldwide. Computed tomography pulmonary angiography and a ventilation/perfusion scan can be used to determine if thromboembolic occlusion is causing pulmonary hypertension in patients. Get the full story on our sister site, Medical Design &Outsourc...
Source: Mass Device - Category: Medical Devices Authors: Tags: Food & Drug Administration (FDA) Bayer Merck Source Type: news
MONDAY, Dec. 10, 2018 -- For individuals with asthma, increased fine particulate matter (PM2.5) exposure is associated with increased weekly rescue inhaler use, according to a study published online Nov. 26 in the Proceedings of the National Academy...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Clinical laboratory leaders will want to pay close attention to a significant development in Maryland. The state’s All-Payer Medicare program—the nation’s only all-payer hospital rate regulation system—is broadening in scope to include outpatient services starting Jan. 1. The expanded program could impact independent medical laboratories, according to the Maryland Hospital Association (MHA), which told Dark […]
Source: Dark Daily - Category: Laboratory Medicine Authors: Tags: Compliance, Legal, and Malpractice Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Management & Operations Uncategorized All-Payer Model anatomic pathology asthma Blue Cross and Blue Shie Source Type: news
ConclusionsExposure to household pollution is associated with poorer control, greater severity, and poorer pulmonary function; double-exposed individuals have a greater risk of severe asthma and decreased lung function than those exposed only to household pollution.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
PDF Version (578 KB) About This Article Published: 17 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Randomized Trial of Interventions ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Science Selection Source Type: research
Conclusions: Among children with asthma and chronic exposure to woodsmoke, an air-filter intervention that improved indoor air quality did not affect quality-of-life measures. Intent-to-treat analysis did show an improvement in the secondary measure of dPFV. Trial registration: ClincialTrials.gov NCT00807183. https://doi.org/10.1289/EHP849 Received: 21 July 2016 Revised: 13 June 2017 Accepted: 16 June 2017 Published: 13 September 2017 Address correspondence to C.W. Noonan, School of Public and Community Health Sciences, 32 Campus Dr., University of Montana, Missoula, MT 59812 USA. Telephone: (406) 243-4957; Fax: (406...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions These data are consistent with, and extend, previously published results demonstrating the efficacy of lebrikizumab in improving rate of asthma exacerbations and lung function in patients with moderate-to-severe asthma who remain uncontrolled despite current standard-of-care treatment. Trial registration numbers The LUTE study was registered under NCT01545440 and the VERSE study under NCT01545453 at http://www.clinicaltrials.gov
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Open access, Asthma, Drugs: respiratory system Respiratory research Source Type: research
More News: Asthma | Chemistry | Noonan Syndrome