Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01051
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research

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ConclusionsA history of asthma or sinonasal disease may modulate immunological response to reduce incidence of active TB in the adult population.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 18 August 2018Source: Saudi Journal of Biological SciencesAuthor(s): Shufen Zhu, pengfei Li, hong Suo, jingsheng Dong, liying CuiAbstractPolymorphisms in the gene encoding for A disintegrin and metalloprotease 33 (ADAM33) are closely associated with the risk of bronchial asthma attacks in different populations. We collected blood samples from 248 asthma patients - 130 of the Han ethnic group and 118 of the Mongolian ethnic group - living in the Inner Mongolia region of China, and analyzed the single nuclear polymorphisms (SNPs) of the T1, T2 and V4 loci of the ADAM33 gene using ...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
ASTHMA symptoms include wheezing, difficulty breathing and having a tight chest. But, you should also never ignore having an itch in this unusual place. These are the deadly lung condition ’s signs to watch out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Disclosed are (N)-methanocarba adenine nucleosides, e.g., of the formula (I): as A3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein A, a, R2, and R3 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. Also disclosed are conjugates comprising a dendrimer and one or more ligands, which are functionalized congeners of an agonist or antagonist of a receptor of the G-protein couple...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M3 muscarinic ACh receptors are present in the central nervous system and the periphery.M3R knockout mice are viable and fertile, and have no major morphological abnormalities. They have a lean phenotype. This results from a combination of reduced caloric intake and increased energy expenditure. They eat less food than wild-type mice, possibly because a central cholinergic pathway that stimulates food intake is disrupted. They also expend more e...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
Conclusions: While the number of identified studies was not large, none reported negative impacts of mHealth on selected outcomes. Future studies on mHealth should design interventions with a greater variety of targeted functions and should adopt more rigorous methodologies to strengthen the evidence for its effectiveness in chronic disease management. PMID: 30109152 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
PDF Version (578 KB) About This Article Published: 17 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Randomized Trial of Interventions ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Science Selection Source Type: research
Conclusions: Among children with asthma and chronic exposure to woodsmoke, an air-filter intervention that improved indoor air quality did not affect quality-of-life measures. Intent-to-treat analysis did show an improvement in the secondary measure of dPFV. Trial registration: ClincialTrials.gov NCT00807183. https://doi.org/10.1289/EHP849 Received: 21 July 2016 Revised: 13 June 2017 Accepted: 16 June 2017 Published: 13 September 2017 Address correspondence to C.W. Noonan, School of Public and Community Health Sciences, 32 Campus Dr., University of Montana, Missoula, MT 59812 USA. Telephone: (406) 243-4957; Fax: (406...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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