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Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01051
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research

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BOSTON (CBS) – Health officials say the flu season may be peaking which hopefully means that cases will soon start to decline. There’s some evidence that this is happening in Massachusetts but only time will tell. That said it is still not too late to get a flu shot so please get one. People with flu symptoms often wonder when they should just stay at home or when they should see a doctor. If you have underlying medical conditions like asthma or heart disease or if you’re pregnant and you think you have the flu, call your doctor. They may want to treat you with anti-viral medication. Otherwise healthy o...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Dr. Mallika Marshall Flu Source Type: news
Purpose: Community/retail pharmacists in Greater Manchester (GM) have been providing an inhaler check service to adults for several years. Many adults using this pharmacy service report that they have had their inhaler since childhood/adolescence and have never been shown how to use it. There have also been asthma-related deaths in GM schools in recent years. This led to a bid for funding to bring the pharmacist-led service into schools, for children and young people (CYP) to master their inhaler at an early age —and hopefully to sustain good technique into adulthood with associated positive health outcomes.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Purpose: Allergies are the third most common chronic disease in children under 18 and the sixth leading chronic disease among all age groups in the United States. Allergic rhinitis is prevalent in adolescence and can worsen outcomes in patients with asthma. A quality improvement project was done to develop, test, and reliably implement evidence-based care for allergic rhinitis in adolescents with asthma.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Conclusion: Parent-reported wheezing is more prevalent than GP-recorded asthma diagnoses in the preschool years, and this difference diminishes in primary school-aged children. Further research is needed to evaluate the implications of these differences for the characterisation of longitudinal childhood asthma phenotypes from EHRs. PMID: 29333271 [PubMed]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: BMJ Open Respir Res Source Type: research
ConclusionsThe SCBA does not increase the propensity or severity for EIB in subjects with BHR. Those subjects with asthma but no BHR to inhaled mannitol did not exhibit EIB. The BHR to a hyperosmolar stimulus maybe considered a useful screening tool for potential recruits with a history of asthma. Purpose Protective self-contained breathing apparatus (SCBA) used for firefighting delivers decompressed (cold) dehumidified air that may enhance the severity of exercise-induced bronchoconstriction (EIB) in those susceptible. We investigated the effect of SCBA during exercise on airway caliber in people with asthma and healt...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Applied Sciences Source Type: research
Purpose of review Emerging research on the pediatric microbiome implicates the importance of the microbiome on the development of the immune system, nervous system, and growth. Changes to the microbiome during infancy are associated with the development of chronic illnesses such as asthma and inflammatory bowel disease. Additionally, the microbiome provides protection against certain pathogens, affects vaccine responses, and alters drug metabolism. This review highlights what is known about the microbiome, the establishment of a healthy microbiome and the significance that changes to the microbiome composition have on gr...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: INFECTIOUS DISEASES AND IMMUNIZATION: Edited by Yvonne J. Bryson Source Type: research
PDF Version (578 KB) About This Article Published: 17 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Randomized Trial of Interventions ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Science Selection Source Type: research
Conclusions: Among children with asthma and chronic exposure to woodsmoke, an air-filter intervention that improved indoor air quality did not affect quality-of-life measures. Intent-to-treat analysis did show an improvement in the secondary measure of dPFV. Trial registration: ClincialTrials.gov NCT00807183. https://doi.org/10.1289/EHP849 Received: 21 July 2016 Revised: 13 June 2017 Accepted: 16 June 2017 Published: 13 September 2017 Address correspondence to C.W. Noonan, School of Public and Community Health Sciences, 32 Campus Dr., University of Montana, Missoula, MT 59812 USA. Telephone: (406) 243-4957; Fax: (406...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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