Rare form of deadly eye cancer normally diagnosed in older men is killing young women in North Carolina – and doctors don’t know why
(Natural News) Ophthalmologists in North Carolina were reportedly baffled by the increasing cases of an eye cancer known as ocular melanoma across the state, which affected nearly two dozen people and killed four patients within a 15-mile radius of Huntersville. According to experts, the eye disease affects five in one million patients and may commonly manifest in older men in...
This study investigates the clinical, histologic, immunohistochemical and molecular features of 10 MBAITs.
G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors that transduce signals through interaction with heterotrimeric G-protein subunits (G α, Gβ, and Gy). The aberrant expression, overexpression or signal reprogramming of GPCRs and G-proteins have been linked to cancer initiation, tumor cell growth, metastasis and angiogenesis. Frequent somatic mutations of Gnaq and Gna11 were found in uveal melanomas of humans thereby identifying th ese G-proteins as potential oncogenes in human neoplasia.
This study illustrates the importance and potential of utilizes plasmas to manipulate the redox environment for tumor immune control.
Abstract The ability of uveal melanoma cells to enter and exit dormancy plays a fundamental role in the development of metastatic disease. Neddylation blockade is a promising strategy to prolong tumor dormancy via impaired angiogenesis and prevent the establishment of metastases via elimination of cancer stem-like cells. PMID: 29610291 [PubMed - as supplied by publisher]
BAP1 is a ubiquitin carboxy-terminal hydrolase enzyme (UCH) which along with the ASXL1/2 protein forms the PR-DUB, chromatin associated complex which removes monoubiquitin from H2A in nucleosomes regulating gene expression. BAP1 is a tumor suppressor gene commonly mutated gene in clear cell renal cell carcinoma (ccRCC) and other cancers such as uveal melanoma (UM) and mesothelioma. In tumors, BAP1 mutations occur throughout the protein well outside the N-terminal UCH catalytic region while C-terminal BAP1 truncations/mutations in the ULD domain also inactivate BAP.
Thoughout medical school and internship, ophthalmologists are trained to recognize ocular abnormalities, disorders, and diseases and to manage those conditions using available medications and procedures. By and large, most ophthalmologists ’ patients are systemically healthy and, despite experiencing potentially blinding conditions, do not typically present life-and-death situations. Some clinicians who have chosen ocular oncology as a subspecialty have to learn (sometimes the hard way) how to navigate the landscape of cancer care, which is highly complex and emotionally and psychologically charged.
This article is protected by copyright. All rights reserved. PMID: 29570931 [PubMed - as supplied by publisher]
Condition: Eye and Orbit Interventions: Biological: Ipilimumab; Biological: Nivolumab; Drug: Embolization Therapy Sponsors: Sidney Kimmel Cancer Center at Thomas Jefferson University; Bristol-Myers Squibb Not yet recruiting