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Rare form of deadly eye cancer normally diagnosed in older men is killing young women in North Carolina – and doctors don’t know why

(Natural News) Ophthalmologists in North Carolina were reportedly baffled by the increasing cases of an eye cancer known as ocular melanoma across the state, which affected nearly two dozen people and killed four patients within a 15-mile radius of Huntersville. According to experts, the eye disease affects five in one million patients and may commonly manifest in older men in...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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A 82-year-old woman with histopathologically proven, locally advanced, multifocal, infiltrative basal cell carcinomas (BCCs) of the centro-facial area and the d écolleté was referred to the skin cancer unit, Medical University of Graz (Austria). She was not considered a candidate for surgery or radiotherapy, so she started treatment with the hedgehog (HH) inhibitor vismodegib (150 mg/day orally). Owing to increasing dysgeusia and muscle cramps, the dosag e of vismodegib was continuously reduced after the first 3 months to 150 mg every second day (month 4), to every third day (month 5) until twice/we...
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research
In this study, we examined the expression of nestin in primary (PUM) and metastatic uveal melanoma (MUM) samples, and correlated the findings with histological, clinical and survival data. MethodsNestin expression was assessed by immunohistochemistry in 141 PUM and 26 MUM samples; 11 PUM cases were matched with their corresponding metastases. The percentage of tumour cells expressing nestin was scored by three independent observers. Statistical analysis of all data was performed with SPSS. ResultsNestin expression was identified in both the cytoplasm and membrane of UM cells. Increased expression of nestin in PUM samples w...
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Original Article Source Type: research
ConclusionThis study provides evidence that a novel UM volume estimation method might offer a practical and cost‐efficient alternative to improve the prognostic value intrinsic to a tumour's size.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Original Article Source Type: research
This study evaluated outcomes of iris melanoma per the AJCC classification, eighth edition.
Source: Ophthalmology - Category: Opthalmology Authors: Tags: Original Article Source Type: research
Nearly two dozen cases of ocular melanoma have been diagnosed in and near Huntersville, North Carolina, and researchers have not found any environmental or genetic link.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Jessica Boesmiller, 37, from Charlotte, North Carolina, was diagnosed with ocular melanoma while eight months pregnant and had her right eye removed three weeks later.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: Multifocal choroidal melanoma is exceedingly rare. Patients with uveal melanoma, especially if multifocal, and those with other systemic malignancy or family history of cancers should be tested for germ line BRCA-associated protein 1 mutation. Lifelong monitoring for other systemic malignancies is advised.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
Conclusion Our preliminary results are encouraging and are comparable to another countries worldwide. The use of Iodine -125 COMs plaque therapy at the inspection of implementation of plaque therapy in the developing countries can lead to eye salvage in more than 90% of cases, and reserves functional vision in more than 50% of cases.
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Saccharomyces cerevisiaeThe translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation. The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact tRNAi, mRNA, or 18S rRNA exclusively in the closed state. Interestingly, EIF1AX mutations altering the human eIF1A NTT are associated with uveal melanoma (UM). We found that substituting all five basic residues, and seven UM-associated substitutions, in yeast eIF1A suppres...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Saccharomyces cerevisiae Source Type: research
Conclusion: Multifocal choroidal melanoma is exceedingly rare. Patients with uveal melanoma, especially if multifocal, and those with other systemic malignancy or family history of cancers should be tested for germ line BRCA-associated protein 1 mutation. Lifelong monitoring for other systemic malignancies is advised.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
More News: Cancer | Cancer & Oncology | Eye Cancers | Melanoma | Opthalmology | Skin Cancer | Women