Spinal Cord Gray Matter Atrophy in Amyotrophic Lateral Sclerosis SPINE

This study aimed to quantify cervical spinal gray matter atrophy in amyotrophic lateral sclerosis and investigate its association with clinical disability at baseline and after 1 year. MATERIALS AND METHODS: Twenty-nine patients with amyotrophic lateral sclerosis and 22 healthy controls were scanned with 3T MR imaging. Standard functional scale was recorded at the time of MR imaging and after 1 year. MR imaging data were processed automatically to measure the spinal cord, gray matter, and white matter cross-sectional areas. A statistical analysis assessed the difference in cross-sectional areas between patients with amyotrophic lateral sclerosis and controls, correlations between spinal cord and gray matter atrophy to clinical disability at baseline and at 1 year, and prediction of clinical disability at 1 year. RESULTS: Gray matter atrophy was more sensitive to discriminate patients with amyotrophic lateral sclerosis from controls (P = .004) compared with spinal cord atrophy (P = .02). Gray matter and spinal cord cross-sectional areas showed good correlations with clinical scores at baseline (R = 0.56 for gray matter and R = 0.55 for spinal cord; P
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: SPINE Source Type: research

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AbstractAimTo investigate whether primary lateral sclerosis (PLS) represents part of the amyotrophic lateral sclerosis –frontotemporal dementia (ALS–FTD) spectrum of diseases.MethodsComprehensive assessment was taken on 21 patients with PLS and results were compared to patients diagnosed with pure motor ALS (n = 27) and ALS–FTD (n = 12). Clinical features, Addenbrooke’s Cognitive Examination (ACE) scores, Motor Neuron Disease Behaviour (Mind-B) scores, motor disability on the ALS functional rating scale (ALSFRS) and survival times were documented. Motor cortex excitabilit...
Source: Journal of Neurology - Category: Neurology Source Type: research
Authors: Dharmadasa T, Huynh W, Tsugawa J, Shimatani Y, Ma Y, Kiernan MC Abstract INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive muscle weakness and disability, eventually leading to death. Heterogeneity of disease has become a major barrier to understanding key clinical questions such as prognosis and disease spread, and has disadvantaged clinical trials in search of therapeutic intervention. Patterns of disease have been explored through recent advances in neuroimaging, elucidating structural, molecular and functional changes. Unique brain signatures have eme...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
I woke up Wednesday morning to the news that Stephen Hawking had passed away. My first thought made me smile — that this incredible scientist who seemed to just will himself to stay alive against overwhelming odds, died on March 14th — Pi Day. Maybe that was his choice. Who knows? Stephen Hawking was a thinker — a brilliant scientist, professor and author who was known for his groundbreaking work in physics and cosmology. His books aimed to make science accessible to everyone. His more well-known works include A Brief History of Time, The Universe in a Nutshell, and A Briefer History of Time. At th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Celebrities Grief and Loss Health-related Inspiration & Hope Memory and Perception Personal ALS Amyotrophic Lateral Sclerosis Depression Gratitude Lou Gehrig's Disease Motor Neuron Disease Stephen Hawking Source Type: blogs
(LONDON) — Stephen Hawking, whose brilliant mind ranged across time and space though his body was paralyzed by disease, died early Wednesday, a University of Cambridge spokesman said. He was 76 years old. Hawking died peacefully at his home in Cambridge, England. The best-known theoretical physicist of his time, Hawking wrote so lucidly of the mysteries of space, time and black holes that his book, “A Brief History of Time,” became an international best seller, making him one of science’s biggest celebrities since Albert Einstein. “He was a great scientist and an extraordinary man whose work a...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized onetime overnight remembrance Source Type: news
This article is protected by copyright. All rights reserved. PMID: 29513402 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
In this issue ofBrain David Brenner and colleagues report a hot-spot of mutations in the kinesin family geneKIF5A causing familial amyotrophic lateral sclerosis, adding to the existing genetic evidence implicating altered cytoskeletal function and intracellular transport in this disease. Two other papers broaden the range of manifestations of genetic disorders involving glutamate receptors. Juliette Piard, George Umanah, Frederike Harms and co-workers identify a mutation in the AAA+ family ATPase Thorase, encoded byATAD1, which leads to lethal encephalopathy and arthrogryposis, while Andrew Fry, Katherine Fawcett and colle...
Source: Brain - Category: Neurology Source Type: research
Authors: Silani V Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease resulting in increasing disability, being uniformly fatal. Since its approval in the 1990s, riluzole remained for long time the unique treatment, offering modest survival benefit. Most recently a second drug has been approved by the US Food and Drug Administration for treatment of ALS: edaravone. Significant advances have been made in the symptomatic management of the disease but more effective drug therapy targeting disease progression is still dreadfully needed, the success appearing almost a miracle. Recent ...
Source: Archives Italiennes de Biologie - Category: Neuroscience Tags: Arch Ital Biol Source Type: research
CONCLUSIONS: This study of peer group rehabilitation for persons with amyotrophic lateral sclerosis and relatives indicates that programme participation leads to positive experiences in terms of living a shared meaningful life despite severe disability. The findings may guide practice to develop longitudinal peer group rehabilitation programmes with joint inclusion of persons with amyotrophic lateral sclerosis and relatives. Implications for Rehabilitation Peer group rehabilitation may facilitate an increased and personalised understanding of what it means to live with amyotrophic lateral sclerosis. A programme design with...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
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Source: Neurologia - Category: Neurology Source Type: research
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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