Spinal Cord Gray Matter Atrophy in Amyotrophic Lateral Sclerosis SPINE

This study aimed to quantify cervical spinal gray matter atrophy in amyotrophic lateral sclerosis and investigate its association with clinical disability at baseline and after 1 year. MATERIALS AND METHODS: Twenty-nine patients with amyotrophic lateral sclerosis and 22 healthy controls were scanned with 3T MR imaging. Standard functional scale was recorded at the time of MR imaging and after 1 year. MR imaging data were processed automatically to measure the spinal cord, gray matter, and white matter cross-sectional areas. A statistical analysis assessed the difference in cross-sectional areas between patients with amyotrophic lateral sclerosis and controls, correlations between spinal cord and gray matter atrophy to clinical disability at baseline and at 1 year, and prediction of clinical disability at 1 year. RESULTS: Gray matter atrophy was more sensitive to discriminate patients with amyotrophic lateral sclerosis from controls (P = .004) compared with spinal cord atrophy (P = .02). Gray matter and spinal cord cross-sectional areas showed good correlations with clinical scores at baseline (R = 0.56 for gray matter and R = 0.55 for spinal cord; P
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: SPINE Source Type: research

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Augmentative and alternative communication (AAC) is typically used by people with severe speech and physical disabilities and is one of the main application areas for the brain–computer interface (BCI) technology. The target population includes people with cerebral palsy, amyotrophic lateral sclerosis, and locked-in syndrome. Word-based AAC systems are mainly faster than letter-based counterparts and are usually supplemented by icons to aid the users. Those icon-based AAC systems that use binary signaling methods such as single click can convert into a single-input BCI system such as event-related potential (ERP) det...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - Category: Neuroscience Source Type: research
We compared the functioning of two neurological patient groups, amyotrophic lateral sclerosis (ALS) and traumatic brain injury (TBI), using brief and validated International Classification of Functioning (ICF)-based tools. A 12-item World Health Organization Disability Assessment Schedule (WHODAS 2.0) questionnaire was mailed to ALS and TBI patients and their significant others 2 weeks before their appointment at an outpatient clinic of a university hospital. In addition, a neurologist filled in the ICF minimal generic set. Two years after diagnosis, no significant differences between the two diagnosis groups were found in...
Source: International Journal of Rehabilitation Research - Category: Rehabilitation Tags: Original articles Source Type: research
CONCLUSIONS: Performance on the ACE was comparable between patients and controls. Associations with motor function pose a challenge to accurate interpretation of ACE performance. It is likely that patients with poor cognition have greater disability, or that poor ACE performance reflects reduced motor ability to perform the task. This raises concern for the utility of the ACE as a screening tool in ALS patients, especially since recent versions of the ACE continue to include motor-based tasks. PMID: 30079844 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - Category: Neurology Authors: Tags: Can J Neurol Sci Source Type: research
This study may serve disabled people to control assistive devices in natural, unobtrusive, speedy and reliable manner. Moreover, it is expected that GKP-based TMI could be a collaboration channel for traditional electroencephalography (EEG)-based brain computer interfaces which have significant inadequacies arisen from the EEG signals.
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Katharina Linse, Elisa Aust, Markus Joos, Andreas Hermann
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: The BCI and PoE technology, combined with smart home system, overcoming the shortcomings of traditional systems and achieving home applications management rely on EEG signal. In this paper, we proposed an online steady-state visual evoked potential (SSVEP) based BCI system on controlling several smart home devices. PMID: 30103356 [PubMed - as supplied by publisher]
Source: Technology and Health Care - Category: Medical Devices Authors: Tags: Technol Health Care Source Type: research
Conclusions Disability proved to be the main variable related to the presence of sexual dysfunction. Patients with ALS had the worst rates of sexual dysfunction. Patients with MS were similar to the control group. As for the PD group, no patient had normal sexuality. Finally, in stroke patients, the presence of comorbidities and their treatment may have negatively influenced sexuality. These findings showed that patients with chronic neurological diseases have sexual dysfunction and underscore the need for neurologists to know and address this problem.RESUMO Las enfermedades neurol ógicas crónicas generan dis...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
AbstractIntroductionExtrapyramidal deficits are poorly characterised in amyotrophic lateral sclerosis (ALS) despite their contribution to functional disability, increased fall risk and their quality-of-life implications. Given the concomitant pyramidal and cerebellar degeneration in ALS, the clinical assessment of extrapyramidal features is particularly challenging.ObjectiveThe comprehensive characterisation  of postural instability in ALS using standardised clinical assessments, gait analyses and computational neuroimaging tools in a prospective study design.MethodsParameters of gait initiation in the anticipatory po...
Source: Journal of Neurology - Category: Neurology Source Type: research
ConclusionThe findings suggested that bilateral motor cortex thinning presented in bulbar-onset ALS and extra-motor cortex thinning presented in spinal-onset ALS. The motor cortex thinning may be the intrinsic pathophysiological change that associated to the disease disability, and extra-motor cortex thinning may be secondary pathophysiological change that associated to disease duration.
Source: Chinese Medical Sciences Journal - Category: General Medicine Source Type: research
This study may serve disabled people to control assistive devices in natural, unobtrusive, speedy and reliable manner. Moreover, it is expected that GKP-based TMI could be a collaboration channel for traditional electroencephalography (EEG)-based brain computer interfaces which have significant inadequacies arisen from the EEG signals.
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
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