How Big is Too Big: Pushing the Obesity Limits in Microsurgical Breast Reconstruction

Conclusions We found obese women to have a higher rate of abdominal donor site complications; however, this risk seems to level off at class I or II obesity. We have modified our surgical technique of managing the abdominal donor site to optimize our outcomes in the morbidly obese patient population.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Microsurgery Source Type: research

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Conditions:   Breast Cancer Female;   Overweight and Obesity Intervention:   Behavioral: Combined aerobic and resistance exercise Sponsors:   University of Colorado, Denver;   Colorado Clinical&Translational Sciences Institute;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurposeTo examine the association between obesity measured by body mass index (BMI) and waist circumference (WC) according to menopausal status in Korean women.MethodsWe identified 6,467,388 women, using the Korean National Health Insurance System Cohort. Cox-proportional hazard models were used to generate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for breast cancer risk in relation to BMI and WC.ResultsIn postmenopausal women, the risk of breast cancer increased with BMI. Compared to women with a BMI of 18.5 –23 kg/m two, the risk of invasive breast cancer was lower in patients with BMI 
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Obesity is an independent risk factor for disease recurrence and death in breast cancer. Growing evidence demonstrates that women with obesity are at increased risk of triple negative breast cancer (TNBC), a breast cancer subtype notable for aggressive biology and poor prognosis. It is less clearly established whether there is an association between obesity and BMI within TNBC. Therefore, we aimed to examine whether BMI was associated with disease-free (DFS) and overall survival (OS) in patients with TNBC.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Breast Source Type: research
Background: Obesity has been known as a risk factor for the development of breast cancer and also affects survival in women diagnosed with breast cancer. Although its relationship has been reported in Korea, age has been yet a major confounding factor to interpret the hypothesis. Aging is also a risk factor of obesity. We aimed to investigate the correlation between the body mass index (BMI) and overall survival of patients with a breast cancer compared with a public released standard Korean obesity index which was age-matched in a community general population.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Lifestyle, Prevention including Secondary Prevention Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Abstract Obesity is associated with hypercholesterolemia and is a global epidemic. Epidemiological and animal studies revealed cholesterol is an essential regulator of estrogen receptor positive (ER+) breast cancer progression while inhibition of cholesterol accumulation was found to prevent breast tumor growth. Individually, vitamin D and LXR agonist T0901317 showed anticancer properties. The present study investigated the effects of vitamin D3 (VD3, calcitriol), LXR agonist (T0901317) and a combination of VD3 + T0901317 on cholesterol metabolism and cancer progression in ER+ breast cancer (MCF-7) c...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Overkill: When Modern Medicine Goes Too Far by Paul Offit M.D.I am admittedly a huge fanboy of Paul Offit, an infectious disease guru at Children's Hospital of Philadelphia, one of the preeminent pediatric hospitals in the world. His latest bookOverall: When Modern Medicine Goes Too Far, is a collection of medical facts that are already known to the well-read individual, but fly in the face of wrongly-held, out-dated, commonly-believed medical concepts. The majority of the incorrect information was previously considered the standard of care, but newer and better science and studies have clearly demonstrated ...
Source: A Pediatrician's Blog - Category: Pediatrics Source Type: blogs
In conclusion, exercise participation had a positive effect on activity restriction, QoL, and hematopoietic profile in breast cancer survivors; in particular, some modalities of aerobic exercise were more effective.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study aimed to investigate the onset and persistence of metabolic syndrome in breast cancer survivors in a community setting. The study included 329 female breast cancer survivors from 39 community health examination centers located in 14 urban areas in Korea. After an average of 4.6 years of follow-up, based on the presence of metabolic syndrome at baseline and follow-up, the subjects were assigned to three groups: Non-metabolic syndrome (n = 249), onset (n = 32), and persistent (n = 48). Factors associated with the metabolic syndrome were analyzed and presented as odds ratios (ORs). Older age, postmenopausal status,...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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